https://podcast.carverupton.com/haidut-blog en-us Unofficial audio narration of new posts from haidut.me, generated automatically with local text-to-speech. Not affiliated with the site. haidut.me (unofficial audio mirror) carver.upton@gmail.com false https://podcast.carverupton.com/haidut-blog/cover.jpg?v=1791318861 https://podcast.carverupton.com/haidut-blog Thu, 15 Oct 2026 00:29:09 +0000 https://haidut.me/?p=3141 https://haidut.me/?p=3141 Wed, 07 Oct 2026 18:13:14 +0000 00:01:16 false https://haidut.me/?p=3139 https://haidut.me/?p=3139 Wed, 07 Oct 2026 17:36:49 +0000 00:03:40 false https://haidut.me/?p=3137 https://haidut.me/?p=3137 Thu, 01 Oct 2026 17:44:43 +0000 00:02:41 false https://haidut.me/?p=3134 https://haidut.me/?p=3134 Thu, 01 Oct 2026 17:07:25 +0000 00:03:05 false https://haidut.me/?p=3131 https://haidut.me/?p=3131 Fri, 25 Sep 2026 01:46:17 +0000 00:02:24 false https://haidut.me/?p=3128 https://haidut.me/?p=3128 Fri, 25 Sep 2026 01:19:31 +0000 00:00:57 false https://haidut.me/?p=3126 https://haidut.me/?p=3126 Fri, 25 Sep 2026 00:46:54 +0000 00:04:04 false https://haidut.me/?p=3124 https://haidut.me/?p=3124 Fri, 25 Sep 2026 00:01:41 +0000 00:01:54 false https://haidut.me/?p=3122 https://haidut.me/?p=3122 Thu, 24 Sep 2026 23:36:58 +0000 00:02:11 false https://haidut.me/?p=3119 https://haidut.me/?p=3119 Thu, 24 Sep 2026 23:15:34 +0000 00:01:08 false https://haidut.me/?p=3117 https://haidut.me/?p=3117 Thu, 24 Sep 2026 22:39:42 +0000 00:01:14 false https://haidut.me/?p=3114 https://haidut.me/?p=3114 Thu, 24 Sep 2026 22:17:18 +0000 90% of filtered free carnitine is reabsorbed in the renal tubules via OCTN2 (Evans and Fornasini 2003; Stanley 2004). The reported IC50 value for famotidine as an OCTN2 inhibitor is 1,920 μM (Glube et al. 2007), suggesting that it exerts only a relatively minor inhibitory effect. However, the findings of this study indicate that famotidine administration can affect L-carnitine supplementation in replacement therapy, thereby consequently having a significant impact on free carnitine concentrations. The urinary excretion rate of unchanged famotidine is reportedly in the range 21.0 to 44.0% (Inotsume et al. 1989; Gao et al. 1991). Despite its high IC50 value, the relatively high urinary excretion rate suggests that a possible effect of famotidine on OCTN2-mediated reabsorption cannot be ruled out.”]]> 00:03:56 false https://haidut.me/?p=3111 https://haidut.me/?p=3111 Thu, 24 Sep 2026 21:19:19 +0000 00:02:02 false https://haidut.me/?p=3107 https://haidut.me/?p=3107 Fri, 24 Jul 2026 06:05:14 +0000 00:02:13 false https://haidut.me/?p=3104 https://haidut.me/?p=3104 Fri, 24 Jul 2026 01:19:45 +0000 00:01:24 false https://haidut.me/?p=3102 https://haidut.me/?p=3102 Thu, 23 Jul 2026 22:46:11 +0000 00:02:13 false https://haidut.me/?p=3099 https://haidut.me/?p=3099 Thu, 23 Jul 2026 17:46:57 +0000 00:02:03 false https://haidut.me/?p=3097 https://haidut.me/?p=3097 Thu, 23 Jul 2026 17:28:10 +0000 00:00:58 false https://haidut.me/?p=3095 https://haidut.me/?p=3095 Thu, 23 Jul 2026 07:17:31 +0000 00:01:15 false https://haidut.me/?p=3093 https://haidut.me/?p=3093 Thu, 23 Jul 2026 06:40:19 +0000 00:01:00 false https://haidut.me/?p=3091 https://haidut.me/?p=3091 Thu, 23 Jul 2026 06:29:41 +0000 00:01:54 false https://haidut.me/?p=3089 https://haidut.me/?p=3089 Thu, 23 Jul 2026 03:26:02 +0000 00:01:35 false https://haidut.me/?p=3087 https://haidut.me/?p=3087 Thu, 23 Jul 2026 03:12:36 +0000 00:02:45 false https://haidut.me/?p=3084 https://haidut.me/?p=3084 Thu, 23 Jul 2026 02:47:58 +0000 00:01:25 false https://haidut.me/?p=3082 https://haidut.me/?p=3082 Thu, 23 Jul 2026 02:35:11 +0000 00:01:02 false https://haidut.me/?p=3080 https://haidut.me/?p=3080 Thu, 23 Jul 2026 02:00:19 +0000 00:00:52 false https://haidut.me/?p=3078 https://haidut.me/?p=3078 Thu, 23 Jul 2026 01:50:04 +0000 00:00:54 false https://haidut.me/?p=3076 https://haidut.me/?p=3076 Wed, 22 Jul 2026 21:32:19 +0000 00:01:40 false https://haidut.me/?p=3074 https://haidut.me/?p=3074 Wed, 22 Jul 2026 21:17:26 +0000 00:00:42 false https://haidut.me/?p=3072 https://haidut.me/?p=3072 Wed, 22 Jul 2026 20:37:44 +0000 00:01:51 false https://haidut.me/?p=3070 https://haidut.me/?p=3070 Sun, 24 May 2026 19:48:29 +0000 00:04:11 false https://haidut.me/?p=3068 https://haidut.me/?p=3068 Sun, 24 May 2026 08:19:24 +0000 00:05:04 false https://haidut.me/?p=3066 https://haidut.me/?p=3066 Sun, 24 May 2026 08:01:08 +0000 00:04:33 false https://haidut.me/?p=3063 https://haidut.me/?p=3063 Sun, 24 May 2026 07:35:31 +0000 00:04:53 false https://haidut.me/?p=3053 https://haidut.me/?p=3053 Sun, 24 May 2026 06:20:02 +0000 00:04:38 false https://haidut.me/?p=3050 https://haidut.me/?p=3050 Sun, 24 May 2026 05:53:17 +0000 00:05:18 false https://haidut.me/?p=3048 https://haidut.me/?p=3048 Sun, 24 May 2026 05:29:26 +0000 00:06:43 false https://haidut.me/?p=3046 https://haidut.me/?p=3046 Sun, 24 May 2026 05:10:43 +0000 00:05:22 false https://haidut.me/?p=3044 https://haidut.me/?p=3044 Sun, 24 May 2026 03:42:40 +0000 00:06:49 false https://haidut.me/?p=3041 https://haidut.me/?p=3041 Sun, 24 May 2026 03:26:25 +0000 00:04:02 false https://haidut.me/?p=3039 https://haidut.me/?p=3039 Sun, 24 May 2026 03:07:33 +0000 00:05:52 false https://haidut.me/?p=3037 https://haidut.me/?p=3037 Sun, 24 May 2026 02:50:24 +0000 00:06:55 false https://haidut.me/?p=3035 https://haidut.me/?p=3035 Sun, 24 May 2026 01:33:33 +0000 00:04:31 false https://haidut.me/?p=3033 https://haidut.me/?p=3033 Sun, 24 May 2026 01:23:11 +0000 00:03:26 false https://haidut.me/?p=3031 https://haidut.me/?p=3031 Sun, 24 May 2026 01:05:31 +0000 00:03:09 false https://haidut.me/?p=3029 https://haidut.me/?p=3029 Sun, 24 May 2026 00:31:10 +0000 00:03:40 false https://haidut.me/?p=3026 https://haidut.me/?p=3026 Sat, 23 May 2026 23:57:49 +0000 00:02:17 false https://haidut.me/?p=3024 https://haidut.me/?p=3024 Sat, 23 May 2026 23:38:13 +0000 00:02:34 false https://haidut.me/?p=3022 https://haidut.me/?p=3022 Sat, 23 May 2026 22:42:55 +0000 00:02:42 false https://haidut.me/?p=3020 https://haidut.me/?p=3020 Sat, 23 May 2026 21:58:36 +0000 00:02:31 false https://haidut.me/?p=3013 https://haidut.me/?p=3013 Thu, 02 Apr 2026 19:02:42 +0000 00:05:25 false https://haidut.me/?p=3010 https://haidut.me/?p=3010 Wed, 18 Feb 2026 23:56:15 +0000 00:02:05 false https://haidut.me/?p=3007 https://haidut.me/?p=3007 Wed, 18 Feb 2026 22:24:18 +0000 00:02:10 false https://haidut.me/?p=3005 https://haidut.me/?p=3005 Wed, 18 Feb 2026 22:07:51 +0000 00:02:57 false https://haidut.me/?p=3003 https://haidut.me/?p=3003 Wed, 18 Feb 2026 21:46:29 +0000  80%. Results Phase I included 15 patients; median age: 57 years (37–68), 40% women, and 47% with MGMT promoter methylated. The most common side effect was flushing (10/15; 9 grade 1). Two DLTs occurred at 2,500 mg/d niacin (grade 3 thrombocytopenia and hyperbilirubinemia). Niacin dose escalated up to 2000 mg/d is the ongoing RP2D. Interim analysis by central radiology review reported PFS-6 M of 82.3% (CI95% 82.14–82.46%). Conclusion The MTD dose of niacin added to first line treatment in patients with GB is 2000 mg/d. The interim analysis already showed an absolute increase in PFS-6 M of 28%. …”]]> 00:01:06 false https://haidut.me/?p=3000 https://haidut.me/?p=3000 Wed, 18 Feb 2026 21:26:29 +0000 00:01:12 false https://haidut.me/?p=2996 https://haidut.me/?p=2996 Fri, 06 Feb 2026 04:43:13 +0000 00:01:51 false https://haidut.me/?p=2994 https://haidut.me/?p=2994 Fri, 06 Feb 2026 04:13:53 +0000 00:01:27 false https://haidut.me/?p=2992 https://haidut.me/?p=2992 Fri, 06 Feb 2026 03:40:43 +0000 00:01:15 false https://haidut.me/?p=2990 https://haidut.me/?p=2990 Fri, 06 Feb 2026 03:26:03 +0000 00:01:25 false https://haidut.me/?p=2988 https://haidut.me/?p=2988 Fri, 06 Feb 2026 03:04:15 +0000 00:02:08 false https://haidut.me/?p=2983 https://haidut.me/?p=2983 Wed, 28 Jan 2026 08:08:02 +0000 00:01:10 false https://haidut.me/?p=2981 https://haidut.me/?p=2981 Wed, 28 Jan 2026 07:38:22 +0000 00:00:54 false https://haidut.me/?p=2979 https://haidut.me/?p=2979 Wed, 28 Jan 2026 06:33:16 +0000 00:00:44 false https://haidut.me/?p=2977 https://haidut.me/?p=2977 Wed, 28 Jan 2026 06:19:00 +0000 00:02:54 false https://haidut.me/?p=2975 https://haidut.me/?p=2975 Wed, 28 Jan 2026 05:53:02 +0000 00:02:04 false https://haidut.me/?p=2972 https://haidut.me/?p=2972 Tue, 27 Jan 2026 07:47:35 +0000 00:04:27 false https://haidut.me/?p=2970 https://haidut.me/?p=2970 Tue, 27 Jan 2026 06:26:31 +0000 00:01:39 false https://haidut.me/?p=2968 https://haidut.me/?p=2968 Tue, 27 Jan 2026 06:06:55 +0000 00:01:08 false https://haidut.me/?p=2966 https://haidut.me/?p=2966 Tue, 27 Jan 2026 05:50:09 +0000 00:00:43 false https://haidut.me/?p=2964 https://haidut.me/?p=2964 Tue, 27 Jan 2026 05:42:10 +0000 00:02:19 false https://haidut.me/?p=2960 https://haidut.me/?p=2960 Tue, 27 Jan 2026 01:48:21 +0000 00:02:47 false https://haidut.me/?p=2958 https://haidut.me/?p=2958 Tue, 27 Jan 2026 01:27:19 +0000 00:01:05 false https://haidut.me/?p=2956 https://haidut.me/?p=2956 Tue, 27 Jan 2026 01:18:06 +0000 00:03:17 false https://haidut.me/?p=2954 https://haidut.me/?p=2954 Tue, 27 Jan 2026 00:54:55 +0000 00:01:43 false https://haidut.me/?p=2952 https://haidut.me/?p=2952 Mon, 26 Jan 2026 20:01:53 +0000 00:01:29 false https://haidut.me/?p=2950 https://haidut.me/?p=2950 Mon, 26 Jan 2026 19:43:47 +0000 00:03:16 false https://haidut.me/?p=2948 https://haidut.me/?p=2948 Mon, 26 Jan 2026 19:07:18 +0000 00:02:05 false https://haidut.me/?p=2946 https://haidut.me/?p=2946 Mon, 26 Jan 2026 18:42:47 +0000 00:02:01 false https://haidut.me/?p=2944 https://haidut.me/?p=2944 Mon, 26 Jan 2026 18:00:59 +0000 00:01:25 false https://haidut.me/?p=2942 https://haidut.me/?p=2942 Thu, 15 Jan 2026 18:37:05 +0000 00:02:24 false https://haidut.me/?p=2940 https://haidut.me/?p=2940 Thu, 15 Jan 2026 17:36:30 +0000 00:02:11 false https://haidut.me/?p=2938 https://haidut.me/?p=2938 Thu, 15 Jan 2026 15:49:47 +0000 00:01:54 false https://haidut.me/?p=2936 https://haidut.me/?p=2936 Thu, 15 Jan 2026 15:31:13 +0000 00:02:46 false https://haidut.me/?p=2934 https://haidut.me/?p=2934 Tue, 25 Nov 2025 21:59:32 +0000 00:02:05 false https://haidut.me/?p=2931 https://haidut.me/?p=2931 Tue, 25 Nov 2025 21:25:35 +0000 00:02:54 false https://haidut.me/?p=2929 https://haidut.me/?p=2929 Tue, 25 Nov 2025 20:52:46 +0000 00:00:56 false https://haidut.me/?p=2927 https://haidut.me/?p=2927 Tue, 25 Nov 2025 20:43:49 +0000 00:00:50 false https://haidut.me/?p=2923 https://haidut.me/?p=2923 Sat, 22 Nov 2025 23:35:59 +0000 00:02:03 false https://haidut.me/?p=2921 https://haidut.me/?p=2921 Sat, 22 Nov 2025 23:12:48 +0000 00:00:39 false https://haidut.me/?p=2919 https://haidut.me/?p=2919 Sat, 22 Nov 2025 22:56:20 +0000 00:01:27 false https://haidut.me/?p=2915 https://haidut.me/?p=2915 Sat, 22 Nov 2025 21:39:04 +0000 00:02:19 false https://haidut.me/?p=2913 https://haidut.me/?p=2913 Sat, 22 Nov 2025 21:18:05 +0000 00:00:50 false https://haidut.me/?p=2911 https://haidut.me/?p=2911 Sat, 22 Nov 2025 18:08:18 +0000 00:03:44 false https://haidut.me/?p=2908 https://haidut.me/?p=2908 Tue, 28 Oct 2025 23:18:44 +0000 00:04:01 false https://haidut.me/?p=2906 https://haidut.me/?p=2906 Tue, 28 Oct 2025 21:16:48 +0000 00:02:43 false https://haidut.me/?p=2904 https://haidut.me/?p=2904 Tue, 28 Oct 2025 20:58:15 +0000 00:01:50 false https://haidut.me/?p=2902 https://haidut.me/?p=2902 Tue, 28 Oct 2025 20:35:18 +0000 00:02:03 false https://haidut.me/?p=2899 https://haidut.me/?p=2899 Thu, 16 Oct 2025 05:02:50 +0000 IMP->AMP->ADP->ATP salvage pathway and older studies in the former Soviet block counties demonstrated that inosine supplementation has a number of beneficial effects on tissues, immunity, mood, etc. In fact, inosine was used back in the day as kind of over-the-counter (OTC) doping drug by many athletes from those countries as it was believed it would lower inflammation and boost muscle mass/strength. However, subsequent studies in the West apparently failed to replicate the ergogenic effects of inosine and the substance has thus been declared as being little more than a metabolic “waste”, especially given its ability to further metabolize into uric acid and thus contribute to gout. I will soon do a separate post on inosine and its ergogenic effects, but it appears that the study below validates at least the claims for anti-inflammatory effects of inosine. Namely, the study found that in physiological concentrations inosine directly binds to and deactivates the TLR4 receptor, through which endotoxin exerts most of its systemic inflammatory effects. This suggests that the elevations of inosine during stress/disease conditions is likely not just pathological but adaptve as a way to lower systemic inflammation. This makes inosine a true TLR 4 antagonist, and a substance of particular interest given how few such OTC substances are known to medicine and the role of endotoxin/LPS/TLR4 in virtually all chronic conditions. And last but not least, the study below provides a plausible mechanism of action for the known protective effects of inosine in many viral conditions, which appear to exert their damage mostly through systemic inflammation, usually driven by endotoxin/LPS. link here “…Treatment with inosine led to significantly attenuated lung injury, improved pulmonary function, and reduced levels of IL-1β, IL-6, IL-18 and TNF-α. Specifically, inosine promoted M1-to-M2 macrophage polarization, thereby enhancing anti-inflammatory responses. Clodronate liposome depletion led to degradation of protective effects of inosine, indicating a key role of macrophages. Metabolomics analysis revealed that treatment with inosine restored glycolysis, lipid metabolism, and amino acid, link here homeostasis, link here, while transcriptomics analysis, link here showed downregulation, link here of TLR4/NF-κB, PI3K-Akt, and NOD-like receptor pathways, with upregulation of anti-inflammatory genes. In vitro tests indicated that treatment with inosine led to decreased apoptosis rate, link here of LPS-induced 16HBE cells, decreased levels of inflammatory cytokines, and inhibited TLR4, link here activation, and such effects were enhanced by TLR4 inhibitor TAK-242. SPR, link here analysis confirmed that inosine can inhibit signaling of TLR4 via direct binding. Inosine, link here shows protective effects against ALI as it may regulate TLR4 signaling to modulate macrophage polarization, metabolic homeostasis, and inflammatory responses. This study comprehensively integrate multi-omics analysis and functional assays to reveal the direct interaction between inosine and TLR4 for the first time, and provides insights into its anti-inflammatory and immunoregulatory mechanisms.”]]> 00:02:13 false https://haidut.me/?p=2897 https://haidut.me/?p=2897 Thu, 16 Oct 2025 04:38:50 +0000 00:03:32 false https://haidut.me/?p=2895 https://haidut.me/?p=2895 Thu, 16 Oct 2025 03:25:36 +0000 00:01:39 false https://haidut.me/?p=2891 https://haidut.me/?p=2891 Fri, 03 Oct 2025 21:08:38 +0000 00:04:36 false https://haidut.me/?p=2888 https://haidut.me/?p=2888 Fri, 03 Oct 2025 20:08:11 +0000 00:02:37 false https://haidut.me/?p=2886 https://haidut.me/?p=2886 Thu, 02 Oct 2025 18:06:05 +0000 00:03:31 false https://haidut.me/?p=2884 https://haidut.me/?p=2884 Thu, 02 Oct 2025 17:31:42 +0000 00:03:05 false https://haidut.me/?p=2882 https://haidut.me/?p=2882 Thu, 02 Oct 2025 16:58:58 +0000 00:04:13 false https://haidut.me/?p=2880 https://haidut.me/?p=2880 Sat, 27 Sep 2025 18:13:52 +0000 00:04:18 false https://haidut.me/?p=2876 https://haidut.me/?p=2876 Thu, 25 Sep 2025 02:27:31 +0000 00:04:28 false https://haidut.me/?p=2874 https://haidut.me/?p=2874 Wed, 24 Sep 2025 21:08:28 +0000 00:01:15 false https://haidut.me/?p=2872 https://haidut.me/?p=2872 Wed, 24 Sep 2025 20:58:38 +0000 00:01:35 false https://haidut.me/?p=2870 https://haidut.me/?p=2870 Sun, 21 Sep 2025 23:28:20 +0000 00:04:45 false https://haidut.me/?p=2865 https://haidut.me/?p=2865 Fri, 19 Sep 2025 20:45:04 +0000 00:02:07 false https://haidut.me/?p=2863 https://haidut.me/?p=2863 Fri, 19 Sep 2025 20:31:57 +0000 00:02:29 false https://haidut.me/?p=2861 https://haidut.me/?p=2861 Fri, 19 Sep 2025 18:44:29 +0000 00:01:07 false https://haidut.me/?p=2859 https://haidut.me/?p=2859 Fri, 19 Sep 2025 18:36:35 +0000 00:01:02 false https://haidut.me/?p=2856 https://haidut.me/?p=2856 Thu, 18 Sep 2025 13:46:07 +0000 00:02:48 false https://haidut.me/?p=2854 https://haidut.me/?p=2854 Thu, 18 Sep 2025 13:16:52 +0000 00:01:32 false https://haidut.me/?p=2852 https://haidut.me/?p=2852 Thu, 18 Sep 2025 06:03:19 +0000 00:01:01 false https://haidut.me/?p=2850 https://haidut.me/?p=2850 Thu, 18 Sep 2025 05:53:49 +0000 00:00:52 false https://haidut.me/?p=2848 https://haidut.me/?p=2848 Thu, 18 Sep 2025 05:29:00 +0000 00:02:28 false https://haidut.me/?p=2846 https://haidut.me/?p=2846 Wed, 17 Sep 2025 20:52:57 +0000 00:01:14 false https://haidut.me/?p=2844 https://haidut.me/?p=2844 Wed, 17 Sep 2025 20:34:32 +0000 00:01:39 false https://haidut.me/?p=2842 https://haidut.me/?p=2842 Wed, 17 Sep 2025 20:22:41 +0000 00:01:45 false https://haidut.me/?p=2839 https://haidut.me/?p=2839 Wed, 17 Sep 2025 20:05:50 +0000 00:01:18 false https://haidut.me/?p=2837 https://haidut.me/?p=2837 Wed, 17 Sep 2025 18:40:17 +0000 00:01:50 false https://haidut.me/?p=2835 https://haidut.me/?p=2835 Wed, 17 Sep 2025 18:18:38 +0000 00:01:32 false https://haidut.me/?p=2833 https://haidut.me/?p=2833 Wed, 17 Sep 2025 18:05:47 +0000 00:02:22 false https://haidut.me/?p=2830 https://haidut.me/?p=2830 Wed, 17 Sep 2025 03:17:16 +0000 00:02:02 false https://haidut.me/?p=2828 https://haidut.me/?p=2828 Wed, 17 Sep 2025 03:02:28 +0000 00:01:15 false https://haidut.me/?p=2824 https://haidut.me/?p=2824 Wed, 17 Sep 2025 02:40:29 +0000 00:00:47 false https://haidut.me/?p=2822 https://haidut.me/?p=2822 Wed, 17 Sep 2025 02:23:57 +0000 00:03:02 false https://haidut.me/?p=2820 https://haidut.me/?p=2820 Wed, 17 Sep 2025 01:45:27 +0000 00:02:27 false https://haidut.me/?p=2818 https://haidut.me/?p=2818 Wed, 17 Sep 2025 01:11:10 +0000 00:01:16 false https://haidut.me/?p=2816 https://haidut.me/?p=2816 Wed, 17 Sep 2025 00:55:21 +0000 00:04:28 false https://haidut.me/?p=2814 https://haidut.me/?p=2814 Tue, 16 Sep 2025 23:37:38 +0000 00:01:08 false https://haidut.me/?p=2812 https://haidut.me/?p=2812 Tue, 16 Sep 2025 23:22:10 +0000 00:01:20 false https://haidut.me/?p=2809 https://haidut.me/?p=2809 Tue, 16 Sep 2025 23:10:54 +0000 00:02:30 false https://haidut.me/?p=2807 https://haidut.me/?p=2807 Tue, 16 Sep 2025 22:53:29 +0000 00:01:32 false https://haidut.me/?p=2805 https://haidut.me/?p=2805 Tue, 16 Sep 2025 21:07:55 +0000  0.05). Notably, the differences in 5HT responses appeared more robust, and the overall reduction in 5HT on positive NPEs observed in ETs was absent in PDs (N-M5: NPE × Patient Group interaction for 5HT; F(1, 545.01) = 4.46, p = 0.035; 5HT response on positive NPE, ET vs. PD t(81.3) = −2.281, Bonferroni corrected p = 0.025).” “…The importance of DA-5HT opponency during reward-related processing has previously been proposed62, link here,63, link here; with fast changes in DA release generally linked to the prediction of rewards and increases in 5HT release associated with an expectation of punishment64, link here,65, link here. ” Key signature sets Parkinson’s and essential tremor apart, link here “…But when they looked closely—using refined tools and a model of how people formed expectations—it was not dopamine that best distinguished Parkinson’s from essential tremor. Instead, it was serotonin, a different neurotransmitter that has not been as prominent in theories of Parkinson’s disease, opening a new view and potentially powerful scientific and clinical insight into this disease. “What surprised us was how much serotonin stood out,” Howe says. “It wasn’t just that dopamine was disrupted, which was expected. It was that the normal back-and-forth between dopamine and serotonin was gone. There’s neither the serotonin dip nor the dopamine rise. It’s not just one system being disrupted—it’s the lack of that dynamic interaction that turned out to be the clearest difference between Parkinson’s and essential tremor.”]]> 00:02:49 false https://haidut.me/?p=2803 https://haidut.me/?p=2803 Tue, 16 Sep 2025 20:39:43 +0000 00:01:46 false https://haidut.me/?p=2801 https://haidut.me/?p=2801 Tue, 16 Sep 2025 20:26:31 +0000 00:03:03 false https://haidut.me/?p=2799 https://haidut.me/?p=2799 Thu, 22 May 2025 20:32:06 +0000 00:02:06 false https://haidut.me/?p=2797 https://haidut.me/?p=2797 Sun, 18 May 2025 02:10:27 +0000 00:02:19 false https://haidut.me/?p=2795 https://haidut.me/?p=2795 Sun, 18 May 2025 01:12:40 +0000 00:03:22 false https://haidut.me/?p=2793 https://haidut.me/?p=2793 Sun, 18 May 2025 00:21:35 +0000 00:03:00 false https://haidut.me/?p=2791 https://haidut.me/?p=2791 Sat, 17 May 2025 23:35:15 +0000 00:01:52 false https://haidut.me/?p=2789 https://haidut.me/?p=2789 Fri, 16 May 2025 20:34:03 +0000 00:02:06 false https://haidut.me/?p=2787 https://haidut.me/?p=2787 Fri, 16 May 2025 20:02:17 +0000 00:01:28 false https://haidut.me/?p=2785 https://haidut.me/?p=2785 Fri, 16 May 2025 19:33:50 +0000 00:01:46 false https://haidut.me/?p=2783 https://haidut.me/?p=2783 Fri, 18 Apr 2025 20:27:08 +0000 00:02:09 false https://haidut.me/?p=2781 https://haidut.me/?p=2781 Fri, 18 Apr 2025 19:18:41 +0000 00:01:08 false https://haidut.me/?p=2779 https://haidut.me/?p=2779 Fri, 18 Apr 2025 18:43:04 +0000 00:02:28 false https://haidut.me/?p=2777 https://haidut.me/?p=2777 Fri, 18 Apr 2025 18:11:17 +0000 00:03:00 false https://haidut.me/?p=2775 https://haidut.me/?p=2775 Fri, 18 Apr 2025 17:45:31 +0000 00:01:43 false https://haidut.me/?p=2773 https://haidut.me/?p=2773 Fri, 18 Apr 2025 16:43:17 +0000 00:02:14 false https://haidut.me/?p=2768 https://haidut.me/?p=2768 Fri, 18 Apr 2025 15:59:28 +0000 00:02:44 false https://haidut.me/?p=2766 https://haidut.me/?p=2766 Thu, 17 Apr 2025 23:34:56 +0000 00:03:15 false https://haidut.me/?p=2764 https://haidut.me/?p=2764 Thu, 17 Apr 2025 22:42:05 +0000 00:02:11 false https://haidut.me/?p=2762 https://haidut.me/?p=2762 Thu, 17 Apr 2025 20:45:28 +0000 00:01:01 false https://haidut.me/?p=2760 https://haidut.me/?p=2760 Thu, 17 Apr 2025 20:32:15 +0000 00:03:11 false https://haidut.me/?p=2758 https://haidut.me/?p=2758 Thu, 17 Apr 2025 19:47:10 +0000 00:02:33 false https://haidut.me/?p=2752 https://haidut.me/?p=2752 Mon, 10 Feb 2025 03:09:38 +0000 00:03:59 false https://haidut.me/?p=2747 http://haidut.me/?p=2747 Tue, 24 Dec 2024 20:16:51 +0000 00:02:43 false https://haidut.me/?p=2744 http://haidut.me/?p=2744 Thu, 12 Dec 2024 15:02:35 +0000 00:02:31 false https://haidut.me/?p=2742 http://haidut.me/?p=2742 Tue, 10 Dec 2024 20:39:54 +0000 00:03:54 false https://haidut.me/?p=2739 http://haidut.me/?p=2739 Tue, 10 Dec 2024 18:45:30 +0000 00:03:47 false https://haidut.me/?p=2737 http://haidut.me/?p=2737 Sun, 08 Dec 2024 16:39:45 +0000 00:03:57 false https://haidut.me/?p=2734 http://haidut.me/?p=2734 Sun, 08 Dec 2024 15:42:49 +0000 00:02:28 false https://haidut.me/?p=2728 http://haidut.me/?p=2728 Sun, 08 Dec 2024 02:17:09 +0000 00:02:06 false https://haidut.me/?p=2730 http://haidut.me/?p=2730 Sun, 08 Dec 2024 02:15:03 +0000 00:03:46 false https://haidut.me/?p=2726 http://haidut.me/?p=2726 Sun, 08 Dec 2024 00:14:09 +0000 00:02:43 false https://haidut.me/?p=2724 http://haidut.me/?p=2724 Sat, 07 Dec 2024 23:38:45 +0000 00:04:52 false https://haidut.me/?p=2722 http://haidut.me/?p=2722 Wed, 20 Nov 2024 21:36:45 +0000 00:02:24 false https://haidut.me/?p=2720 http://haidut.me/?p=2720 Wed, 20 Nov 2024 20:30:28 +0000 00:01:22 false https://haidut.me/?p=2718 http://haidut.me/?p=2718 Wed, 20 Nov 2024 20:21:20 +0000 00:01:08 false https://haidut.me/?p=2716 http://haidut.me/?p=2716 Wed, 20 Nov 2024 19:52:53 +0000 00:07:01 false https://haidut.me/?p=2714 http://haidut.me/?p=2714 Wed, 20 Nov 2024 18:59:24 +0000 00:03:42 false https://haidut.me/?p=2710 http://haidut.me/?p=2710 Fri, 01 Nov 2024 19:28:36 +0000 00:07:10 false https://haidut.me/?p=2708 http://haidut.me/?p=2708 Thu, 31 Oct 2024 18:45:54 +0000 00:02:42 false https://haidut.me/?p=2706 http://haidut.me/?p=2706 Wed, 30 Oct 2024 20:32:03 +0000 00:02:42 false https://haidut.me/?p=2702 http://haidut.me/?p=2702 Mon, 28 Oct 2024 15:51:53 +0000 00:04:43 false https://haidut.me/?p=2700 http://haidut.me/?p=2700 Fri, 25 Oct 2024 17:59:48 +0000 00:02:55 false https://haidut.me/?p=2698 http://haidut.me/?p=2698 Fri, 25 Oct 2024 17:27:52 +0000 00:02:23 false https://haidut.me/?p=2691 http://haidut.me/?p=2691 Tue, 01 Oct 2024 18:36:20 +0000 5α-dihydroprogesterone (5-AR activity) -> allopregnanolone (3α-reductase activity). If fluoxetine selectively increases the activity of only 3α-HSD, then the only thing that can be said for sure is that fluoxetine would increase the levels of a steroid that takes progesterone as input and produces a 3α-reduced steroid, which is a steroid with a hydroxyl group (OH) on position C-3, in the alpha configuration. Once progesterone goes through 3α-HSD, and produces a C-3-ol steroid, the reaction terminates there, since that output steroid cannot undergo processing by 5-AR, as the latter can only accept as input steroids with a keto group on C-3 (progesterone, testosterone, cortisol, etc). However, since the enzyme 3α-HSD is bi-directional (oxido-reductase), the end steroid output may get converted back to progesterone. The output of the progesterone being processed by 3α-HSD is the steroid 3α-Dihydroprogesterone (3α-DHP), link here, and if fluoxetine works primarily by increasing 3α-HSD activity and levels, then a more appropriate hypothesis would be that the anti-depressant and anti-anxiety effects of fluoxetine may be due more to the increased levels of 3α-DHP, and not so much on the increased levels of allopregnanolone. link here Interestingly enough, 3α-DHP has been found to have the same affinity and strength as a GABA agonist as allopregnanolone, and the latter is known as the most potent endogenous GABA agonist agent. As such, multiple studies have demonstrated that 3α-DHP has similar anxiolytic, sedative and analgesic effects as allopregnanolone. In addition, levels of 3α-DHP have been found to be low in many conditions where allopregnanolone levels have also been found to be low. “…3α-Dihydroprogesterone (3α-DHP), also known as 3α-hydroxyprogesterone, as well as pregn-4-en-3α-ol-20-one, is an endogenous, link here neurosteroid, link here.[1], link here It is biosynthesized, link here by 3α-hydroxysteroid dehydrogenase, link here from progesterone, link here.[1], link here 3α-DHP has been found to act as a positive allosteric modulator, link here of the GABAA receptor, link here and is described as being as active as allopregnanolone, link here in regard to this action.[1], link here In accordance, it has anxiolytic, link here effects in animals.[2], link here 3α-DHP has also been found to inhibit the secretion of follicle-stimulating hormone, link here (FSH) from the rat pituitary gland, link here, demonstrating possible antigonadotropic, link here properties.[1], link here Unlike the case of most other inhibitory neurosteroids, 3α-DHP production is not blocked by 5α-reductase inhibitors, link here like finasteride, link here.[1], link here No data were available on the progestogenic activity of 3α-DHP as of 1977.[3], link here Levels of 5α-DHP have been quantified.[4], link here” Strong GABA agonists are known to have a cortisol-lowering effects and there are several published case reports showing successful treatment of Cushing disease/syndrome in some people using the anti-anxiety benzodiazepine drugs (also GABA agonists, but more selective). Being the strongest endogenous GABA agonist, allopregnanolone has also been demonstrated to have cortisol-lowering effects in humans. 3 links here Cortisol is a proven causal factor in depression, confirmed by multiple studies demonstrating rapid antidepressant effects of glucocorticoid antagonists (e.g. Mifepristone/RU486) in both animals and humans, as well as by rapid depressive effects caused by synthetic (e.g. dexamethasone) and natural (e.g. cortisol) glucocorticoid agonists. Since allopregnanolone has been shown to lower cortisol in humans that may explain most of its anti-depressant effects, as well as its anxiolytic effects. link here   4 links here As the Wiki article above states, 3α-DHP is as effective as allopregnanolone in terms of GABA activity, and likely has the same mental/physiological effects. Also, unlike allopregnanolone, 3α-DHP is not affected by administration of 5-AR inhibitor drugs such as finasteride, and is not currently regulated by medical authorities (e.g. FDA) in the US or other any other of the 30+ countries I was able to check. link here “…The effects of the centrally produced allylic neurosteroid, 3 alpha-hydroxy-4-pregnen-20-one (3 alpha HP), on the responses of male mice to an aversive, anxiety-inducing, predator (cat) odor were examined in an odor preference test. Control untreated mice displayed an anxiogenic response to the cat odor, spending a minimal amount of time in a Y-maze in the vicinity of the cat odor. Intracerebroventricular (i.c.v.) administrations of 3 alpha HP had an anxiolytic action, resulting in significant dose-related (0.01-1.0 micrograms) increases in the amount of time spent in the proximity of the cat odor. These anxiolytic effects of 3 alpha HP were stereospecific, with the stereoisomer, 3 beta-hydroxy-4-pregnen-20-one (3 beta HP) having no significant effects on odor preferences. The analgesic, morphine, also had no significant effects on the response to cat odor indicating that the anxiolytic actions of 3 alpha HP were unlikely to be related to any analgesic effects. The effects of 3 alpha HP were significantly reduced by peripheral administrations of the GABAA antagonists, bicuculline and picrotoxin, but were unaffected by either the benzodiazepine antagonist, Ro 15-1788, or the opiate antagonist, naloxone. These results indicate that the allylic neurosteroid 3 alpha HP has anxiolytic actions involving interactions with the GABAA receptor.” link here “…Here we show that brief exposure of male mice to an ELF magnetic field (30 min, 60 Hz, 141 microT peak) significantly reduces the analgesic effects arising from intracerebroventricular (i.c.v.) administration of the centrally produced allylic neuroactive steroid, 3alpha-hydroxy-4-pregnen-20-one (3alphaHP) and that the dihydropyridine (DHP) calcium channel antagonists, diltiazem and nifedipine, block the inhibitory effects of the 60 Hz ELF on 3alphaHP-induced analgesia. These results indicate that exposure to 60 Hz ELF affects the analgesic effects of neuroactive steroids such as 3alphaHP through alterations in calcium channel function. These findings raise the possibility that ELF magnetic fields may, in part, exert their actions through effects on diverse neuroactive steroid modulated processes.” link here “…This allylic steroid elicited significant, dose-dependent (0.001-1.0 micrograms) analgesic responses for 90-150 min after injection. These analgesic effects of 3A4P were stereospecific, the stereoisomer, 3 beta-hydroxy-4-pregnen-20-one (3B4P) failing to affect the nociceptive responses. The analgesic effects of 3A4P were blocked by peripheral administrations of the GABA antagonists, bicuculline and picrotoxin, and reduced by the benzodiazepine antagonist, Ro 15-1788. The exogenous opiate antagonist, naloxone, and the putative endogenous opioid antagonist, Tyr-MIF-1 (Pro-Leu-Gly-amide), also reduced 3A4P-induced analgesia, while i.c.v. administration of 3A4P (0.001 and 0.01 micrograms) itself attenuated the analgesic effects arising from peripheral administrations of opiate receptor agonist, morphine. In addition, the calcium channel antagonists, nifedipine and verapamil, enhanced 3A4P-induced analgesia but had no evident effects on the actions of 3B4P. These results suggest that the central analgesic effects of the FSH-suppressing steroid, 3A4P, arise via benzodiazepine–GABA–opiate mechanisms and calcium channels.” The interesting properties of 3α-DHP are not exhausted by its close mimicry/overlap with allopregnanolone. The studies below suggest that it has a number of other interesting effects, at least in animals, include unique anti-cancer effects NOT shared by allopregnanolone. Since one of the tumor cell lines used in many of those cancer studies was the estrogen-sensitive (ER+) line known as MCF-7, a reasonable conclusion may be that 3α-DHP has anti-estrogenic effects, not shared by its cousin allopregnanolone, as other estrogen antagonists have also showed anti-cancer effects in MCF-7 models. For the record, 3α-DHP also demonstrated inhibitory effects on tumor growth from estrogen- and progesterone-negative cell likes, which suggests its effects are generic/systemic and not only focused on a specific steroid pathway. link here “…Onset and growth of ER/PR-negative human breast cell tumors were significantly stimulated by 5αP and inhibited by 3αHP. When both hormones were applied simultaneously, the stimulatory effects of 5αP were abrogated by the inhibitory effects of 3αHP and vice versa. Treatment with 3αHP subsequent to 5αP-induced tumor initiation resulted in suppression of further tumorigenesis and regression of existing tumors. The levels of 5αP in tumors, regardless of treatment, were about 10-fold higher than the levels of 3αHP, and the 5αP:3αHP ratios were about fivefold higher than in serum, indicating significant changes in endogenous synthesis of these hormones in tumorous breast tissues.” link here “…The studies were conducted on tumorigenic (MCF-7, MDA-MB-231, T47D) and non-tumorigenic (MCF-10A) human breast cell lines, employing several methods to assess the effects of the hormones on cell proliferation, mitosis, apoptosis and expression of Bcl-2, Bax and p21. In all four cell lines, 5alphaP increased, whereas 3alphaHP decreased cell numbers, [(3)H]thymidine uptake and mitotic index. Apoptosis was stimulated by 3alphaHP and suppressed by 5alphaP. 5alphaP resulted in increases in Bcl-2/Bax ratio, indicating decreased apoptosis; 3alphaHP resulted in decreases in Bcl-2/Bax ratio, indicating increased apoptosis. The effects of either 3alphaHP or 5alphaP on cell numbers, [(3)H]thymidine uptake, mitosis, apoptosis, and Bcl-2/Bax ratio, were abrogated when cells were treated simultaneously with both hormones. The expression of p21 was increased by 3alphaHP, and was unaffected by 5alphaP. The results provide the first evidence that 5alphaP stimulates mitosis and suppresses apoptosis, whereas 3alphaHP inhibits mitosis and stimulates apoptosis. The opposing effects of 5alphaP and 3alphaHP were observed in all four breast cell lines examined and the data suggest that all breast cancers (estrogen-responsive and unresponsive) might be suppressed by blocking 5alphaP formation and/or increasing 3alphaHP. ” link here “…Recent evidence suggests that progesterone metabolites play important roles in regulating breast cancer. Previous studies have shown that tumorous tissues have higher 5α-reductase (5αR) and lower 3α-hydroxysteroid oxidoreductase (3α-HSO) and 20α-HSO activities. The resulting higher levels of 5α-reduced progesterone metabolites such as 5α-pregnane-3,20-dione (5αP) in tumorous tissue promote cell proliferation and detachment, whereas the 4-pregnene metabolites, 4-pregnen-3α-ol-20-one (3αHP) and 4-pregnen-20α-ol-3-one (20αDHP), more prominent in normal tissue, have the opposite (anti-cancer-like) effects. The aim of this study was to determine if the differences in enzyme activities between tumorous and nontumorous breast tissues are associated with differences in progesterone metabolizing enzyme gene expression.” “…The study shows changes in progesterone metabolizing enzyme gene expression in human breast carcinoma. Expression of SRD5A1 (5αR1) and SRD5A2 (5αR2) is elevated, and expression of AKR1C1 (20α-HSO), AKR1C2 (3α-HSO3) and AKR1C3 (3α-HSO2) is reduced in tumorous as compared to normal breast tissue. The changes in progesterone metabolizing enzyme expression levels help to explain the increases in mitogen/metastasis inducing 5αP and decreases in mitogen/metastasis inhibiting 3αHP progesterone metabolites found in breast tumor tissues. Understanding what causes these changes in expression could help in designing protocols to prevent or reverse the changes in progesterone metabolism associated with breast cancer.” Furthermore, another study demonstrated striking spermatogenic effects of 3α-DHP, which were much stronger than the spermatogenic effects of testosterone. However, unlike testosterone, DHT and other related steroids, 3α-DHP did not display androgenic effects. Assuming allopregnanolone has similar effects, I would not be surprised if we soon see clinical trials for allopregnanolone (and/or, God forbid, 3α-DHP) as treatments for infertility, especially considering the skyrocketing rates of this issue in most Western/developed countries. link here “…The effect of 3 alpha-hydroxy-4-pregnen-3-one (3HP), a Sertoli cell steroid, on spermatogenesis was examined in normal and gonadotropin-suppressed rats, through s.c. as well as direct intratesticular injections. Early experiments employing normal prepubertal male rats indicated that 3HP, when administered at 65 micrograms/100 g BW daily for 15 days, was capable of stimulating pachytene spermatocyte number to 149% of untreated control numbers. It was of interest to determine if this effect could be amplified in gonadotropin-suppressed animals. Neonatally estrogenized rats (500 micrograms estradiol benzoate in 0.1 ml oil at 2 days) were treated on alternate days with 3HP (100 micrograms/100 g BW) for 3 wk, starting at 7 days of age. This treatment significantly increased the number of spermatocytes per tubule cross section from 17.3 +/- 1.9 (in estradiol benzoate-only animals) to 47.1 +/- 7.9 (p less than 0.01). In a similar study, 100 micrograms/100 g BW of testosterone propionate could stimulate spermatocyte number to only 15.1 +/- 2.2 cells per tubule cross section versus estradiol benzoate-only numbers. A single intratesticular injection of 3HP (2 ng in 2.0 microliters oil) in Methallibure-treated rats resulted in a significant increase in late pachytene spermatocyte numbers from 0.77 +/- 0.12 in Methallibure-only-treated rats to 1.70 +/- 0.10 (p less than 0.001) cells per tubule cross section in 28-day-old rats. However, in this study, no other progesterone metabolite or androgenic steroid (testosterone, 5 alpha-dihydrotestosterone, or 5 alpha-androstan-3 alpha, 17 beta-diol) tested was capable of this level of germ cell stimulation. In conclusion, 3HP appears to have a direct effect on germ cell development within the testis at levels much lower than those shown to be effective for androgens. It does not appear that this effect is mediated through the conversion of 3HP to any C21 or C19 steroids, and appears to be the first report of a Sertoli cell steroid with a possible role in the process of mammalian spermatogenesis.” link here “…Treatment of young (15-day-old) intact males with either 3-HP or 17 beta-hydroxy-5 alpha-androstan-3-one (DHT) for 14 days showed that DHT resulted in significant increases in prostate and seminal vesicle weights, while 3-HP showed no apparent androgenic activity. ” Finally, 3α-DHP seems to have pro-sexual effects (at least in males) as it increased the preference of treated males for the odor of estrous females. While the study discusses GABA agonism by 3α-DHP as the main mechanism in achieving this pro-sexual effects, I suspect there is more at play since the administered GABA abtagonists did not completely block the effect. In my opinion, given the similar structure between 3α-DHP and allopregnanolone, the pro-dopamine and anti-serotonin (5-HT3 blocker) effects of the latter are likely to both be present in the former, and both of those pathways have a known pro-libido and performance enhancing effects. link here “…The effects of the centrally produced allylic neurosteroid, 3 alpha-hydroxy-4-pregnen-20-one (3 alpha HP), on the responses of male mice to the odors of estrous female mice were examined in an odor preference test. Control untreated mice displayed a significant preference for the odors of an estrous female, spending more time in a Y-maze in the vicinity of the odors of an estrous than a non-estrous female. Intracerebroventricular (i.c.v.) administrations of 3 alpha HP enhanced male preference for the odors of estrous females, causing a significant dose-related (0.01-1.0 microgram) increase in the amount of time spent in the proximity of the odors of the estrous female, while having no significant effect on the responses to the non-estrous female odors. These effects of 3 alpha HP were stereospecific, with the stereoisomer, 3 beta-hydroxy-4-pregnen-20-one (3 beta HP), having no significant effects on odor preferences. The analgesic, morphine, also had no significant effects on the responses to female odors suggesting that the enhanced preference for estrous female odors were unlikely to be directly due to any analgesic effects of 3 alpha HP. The effects of 3 alpha HP were significantly reduced by peripheral administrations of the GABAA antagonists, bicuculline and picrotoxin, but were unaffected by either the benzodiazepine antagonist, Ro 15-1788, or the opiate antagonist, naloxone. These results suggest that the neurosteroid 3 alpha HP has facilitatory effects on olfactory mediated male sexual interest or motivation that involve interactions with the GABAA receptor.” All in all, quite an interesting substance, and given its non-regulated nature we decided to release it as a product to the general public. It can be bought from the links below. 2 links here The units listed on the label are just for measurement purposes. They do not indicate or suggest optimal dose. Please note that similar to the liquid products sold by companies like Sigma Aldrich, Spectrum Chemical, Alfa Aesar, etc, this product if for lab/research use only. ******************************************************************************* 3α-DHP is a liquid (very viscous) product containing a bioidentical endogenous neurosteroid known as 3α-dihydroprogesterone (3α-DHP). While that steroid has not been as extensively studied as the closely-related neurosteroid allopregnanolone, 3α-DHP can perhaps be best described as an allopregnanolone mimetic, with similar (though not identical) pharmacological profile and strength (especially on the GABA system). Some of the more unique and interesting properties of 3α-DHP include its anti-cancer effects demonstrated in animal studies, with the notable finding that those anti-cancer effects are NOT shared by neither allopregnanolone nor its precursor neurosteroid 5α-dihydroprogesterone (5α-DHP). In addition, 3α-DHP has demonstrated potent spermatogenic and pro-sexual effects in some animal studies, with the former fax exceeding the effects of any other known and tested steroid (e.g. androgens). Drops per container: about 250 Each drop contains the following ingredients: 3α-dihydroprogesterone (CAS 25680-68-6): 1mg Other ingredients: add product to shopping cart to see info ******************************************************************************* REFERENCES: 7 links here]]> 00:11:26 false https://haidut.me/?p=2689 http://haidut.me/?p=2689 Tue, 24 Sep 2024 19:02:04 +0000 00:01:47 false https://haidut.me/?p=2687 http://haidut.me/?p=2687 Mon, 16 Sep 2024 19:51:40 +0000 00:02:17 false https://haidut.me/?p=2685 http://haidut.me/?p=2685 Tue, 10 Sep 2024 16:51:21 +0000 00:01:24 false https://haidut.me/?p=2683 http://haidut.me/?p=2683 Mon, 09 Sep 2024 19:17:38 +0000 00:05:33 false https://haidut.me/?p=2681 http://haidut.me/?p=2681 Mon, 09 Sep 2024 18:06:44 +0000 00:01:39 false https://haidut.me/?p=2679 http://haidut.me/?p=2679 Mon, 09 Sep 2024 17:29:11 +0000 00:03:21 false https://haidut.me/?p=2677 http://haidut.me/?p=2677 Tue, 27 Aug 2024 16:22:53 +0000 00:01:22 false https://haidut.me/?p=2675 http://haidut.me/?p=2675 Mon, 26 Aug 2024 17:54:17 +0000 00:03:10 false https://haidut.me/?p=2673 http://haidut.me/?p=2673 Mon, 26 Aug 2024 17:08:43 +0000 00:01:57 false https://haidut.me/?p=2671 http://haidut.me/?p=2671 Sun, 25 Aug 2024 22:43:43 +0000 00:00:55 false https://haidut.me/?p=2669 http://haidut.me/?p=2669 Sun, 25 Aug 2024 22:27:40 +0000 00:01:09 false https://haidut.me/?p=2667 http://haidut.me/?p=2667 Sun, 25 Aug 2024 22:17:33 +0000 00:01:07 false https://haidut.me/?p=2664 http://haidut.me/?p=2664 Sun, 25 Aug 2024 21:59:34 +0000 00:01:09 false https://haidut.me/?p=2662 http://haidut.me/?p=2662 Sun, 25 Aug 2024 21:38:23 +0000 00:01:03 false https://haidut.me/?p=2660 http://haidut.me/?p=2660 Sun, 25 Aug 2024 21:24:42 +0000 00:02:01 false https://haidut.me/?p=2658 http://haidut.me/?p=2658 Sun, 25 Aug 2024 21:08:35 +0000 00:01:41 false https://haidut.me/?p=2655 http://haidut.me/?p=2655 Sun, 25 Aug 2024 20:54:26 +0000 00:00:55 false https://haidut.me/?p=2653 http://haidut.me/?p=2653 Sun, 25 Aug 2024 20:44:33 +0000 00:01:17 false https://haidut.me/?p=2651 http://haidut.me/?p=2651 Sun, 25 Aug 2024 20:31:26 +0000 00:01:31 false https://haidut.me/?p=2649 http://haidut.me/?p=2649 Sun, 25 Aug 2024 19:10:23 +0000 00:00:48 false https://haidut.me/?p=2647 http://haidut.me/?p=2647 Sun, 25 Aug 2024 18:58:50 +0000 00:00:42 false https://haidut.me/?p=2645 http://haidut.me/?p=2645 Sun, 25 Aug 2024 18:41:11 +0000 00:01:14 false https://haidut.me/?p=2643 http://haidut.me/?p=2643 Sun, 25 Aug 2024 18:28:28 +0000 00:01:03 false https://haidut.me/?p=2641 http://haidut.me/?p=2641 Sun, 25 Aug 2024 18:12:53 +0000 00:00:42 false https://haidut.me/?p=2639 http://haidut.me/?p=2639 Sun, 25 Aug 2024 18:07:30 +0000 00:00:52 false https://haidut.me/?p=2637 http://haidut.me/?p=2637 Sun, 25 Aug 2024 17:51:29 +0000 00:01:38 false https://haidut.me/?p=2632 http://haidut.me/?p=2632 Sun, 25 Aug 2024 16:40:51 +0000 00:01:54 false https://haidut.me/?p=2629 http://haidut.me/?p=2629 Sun, 25 Aug 2024 16:05:24 +0000 00:01:26 false https://haidut.me/?p=2627 http://haidut.me/?p=2627 Sun, 25 Aug 2024 15:46:20 +0000 00:02:27 false https://haidut.me/?p=2625 http://haidut.me/?p=2625 Sun, 25 Aug 2024 15:27:23 +0000 00:01:01 false https://haidut.me/?p=2623 http://haidut.me/?p=2623 Sun, 25 Aug 2024 15:16:44 +0000 00:01:36 false https://haidut.me/?p=2621 http://haidut.me/?p=2621 Sun, 25 Aug 2024 15:01:40 +0000 00:01:24 false https://haidut.me/?p=2619 http://haidut.me/?p=2619 Sun, 25 Aug 2024 14:51:17 +0000 00:00:32 false https://haidut.me/?p=2616 http://haidut.me/?p=2616 Sun, 25 Aug 2024 14:09:54 +0000 00:03:14 false https://haidut.me/?p=2614 http://haidut.me/?p=2614 Sun, 25 Aug 2024 13:22:10 +0000 00:01:09 false https://haidut.me/?p=2612 http://haidut.me/?p=2612 Sun, 25 Aug 2024 13:03:45 +0000 00:02:53 false https://haidut.me/?p=2610 http://haidut.me/?p=2610 Sun, 25 Aug 2024 04:13:33 +0000 00:01:17 false https://haidut.me/?p=2608 http://haidut.me/?p=2608 Sun, 25 Aug 2024 03:58:16 +0000 00:01:19 false https://haidut.me/?p=2606 http://haidut.me/?p=2606 Sun, 25 Aug 2024 03:38:23 +0000 00:01:01 false https://haidut.me/?p=2604 http://haidut.me/?p=2604 Sun, 25 Aug 2024 03:26:31 +0000 00:00:41 false https://haidut.me/?p=2602 http://haidut.me/?p=2602 Sun, 25 Aug 2024 03:17:56 +0000 00:00:55 false https://haidut.me/?p=2600 http://haidut.me/?p=2600 Sun, 25 Aug 2024 03:01:10 +0000 00:01:35 false https://haidut.me/?p=2598 http://haidut.me/?p=2598 Sun, 25 Aug 2024 02:37:44 +0000 00:02:15 false https://haidut.me/?p=2596 http://haidut.me/?p=2596 Sun, 25 Aug 2024 01:57:49 +0000 00:01:40 false https://haidut.me/?p=2594 http://haidut.me/?p=2594 Sun, 25 Aug 2024 01:34:01 +0000 00:04:22 false https://haidut.me/?p=2592 http://haidut.me/?p=2592 Tue, 23 Jul 2024 18:32:58 +0000 00:01:23 false https://haidut.me/?p=2590 http://haidut.me/?p=2590 Tue, 23 Jul 2024 18:10:44 +0000 00:01:38 false https://haidut.me/?p=2588 http://haidut.me/?p=2588 Tue, 23 Jul 2024 17:48:48 +0000 00:01:40 false https://haidut.me/?p=2586 http://haidut.me/?p=2586 Tue, 23 Jul 2024 17:35:47 +0000 00:01:40 false https://haidut.me/?p=2584 http://haidut.me/?p=2584 Fri, 19 Jul 2024 18:36:30 +0000 00:01:45 false https://haidut.me/?p=2582 http://haidut.me/?p=2582 Fri, 19 Jul 2024 18:04:55 +0000 00:02:41 false https://haidut.me/?p=2580 http://haidut.me/?p=2580 Fri, 19 Jul 2024 17:30:15 +0000 00:02:36 false https://haidut.me/?p=2578 http://haidut.me/?p=2578 Thu, 18 Jul 2024 20:02:09 +0000 00:04:03 false https://haidut.me/?p=2574 http://haidut.me/?p=2574 Wed, 17 Jul 2024 19:29:52 +0000 00:02:28 false https://haidut.me/?p=2572 http://haidut.me/?p=2572 Wed, 17 Jul 2024 18:59:06 +0000 00:02:13 false https://haidut.me/?p=2570 http://haidut.me/?p=2570 Wed, 17 Jul 2024 18:14:12 +0000 00:01:57 false https://haidut.me/?p=2567 http://haidut.me/?p=2567 Wed, 17 Jul 2024 17:47:41 +0000 00:02:21 false https://haidut.me/?p=2565 http://haidut.me/?p=2565 Wed, 17 Jul 2024 17:15:02 +0000 00:03:18 false https://haidut.me/?p=2559 http://haidut.me/?p=2559 Tue, 11 Jun 2024 17:40:52 +0000 00:04:49 false https://haidut.me/?p=2555 http://haidut.me/?p=2555 Thu, 06 Jun 2024 18:17:15 +0000 00:02:09 false https://haidut.me/?p=2552 http://haidut.me/?p=2552 Thu, 06 Jun 2024 17:10:16 +0000 00:02:47 false https://haidut.me/?p=2550 http://haidut.me/?p=2550 Wed, 05 Jun 2024 17:21:21 +0000 00:01:47 false https://haidut.me/?p=2546 http://haidut.me/?p=2546 Wed, 05 Jun 2024 16:54:11 +0000 00:03:07 false https://haidut.me/?p=2542 http://haidut.me/?p=2542 Tue, 04 Jun 2024 18:32:23 +0000 00:02:14 false https://haidut.me/?p=2540 http://haidut.me/?p=2540 Tue, 04 Jun 2024 17:59:06 +0000 00:02:16 false https://haidut.me/?p=2538 http://haidut.me/?p=2538 Mon, 03 Jun 2024 19:17:40 +0000 00:01:42 false https://haidut.me/?p=2535 http://haidut.me/?p=2535 Mon, 03 Jun 2024 18:54:26 +0000 00:03:00 false https://haidut.me/?p=2533 http://haidut.me/?p=2533 Mon, 03 Jun 2024 18:10:41 +0000 00:01:09 false https://haidut.me/?p=2531 http://haidut.me/?p=2531 Mon, 03 Jun 2024 17:54:22 +0000 00:01:09 false https://haidut.me/?p=2528 http://haidut.me/?p=2528 Mon, 03 Jun 2024 17:40:02 +0000 00:01:44 false https://haidut.me/?p=2526 http://haidut.me/?p=2526 Mon, 03 Jun 2024 17:20:31 +0000 00:01:03 false https://haidut.me/?p=2524 http://haidut.me/?p=2524 Mon, 03 Jun 2024 17:09:31 +0000 00:02:24 false https://haidut.me/?p=2520 http://haidut.me/?p=2520 Fri, 24 May 2024 19:12:04 +0000 00:01:55 false https://haidut.me/?p=2516 http://haidut.me/?p=2516 Thu, 18 Apr 2024 17:00:46 +0000 00:02:40 false https://haidut.me/?p=2514 http://haidut.me/?p=2514 Fri, 22 Mar 2024 19:57:20 +0000 00:04:42 false https://haidut.me/?p=2511 http://haidut.me/?p=2511 Fri, 22 Mar 2024 15:21:50 +0000 00:02:42 false https://haidut.me/?p=2509 http://haidut.me/?p=2509 Fri, 22 Mar 2024 14:53:07 +0000 00:01:14 false https://haidut.me/?p=2507 http://haidut.me/?p=2507 Mon, 04 Mar 2024 19:05:35 +0000 00:01:05 false https://haidut.me/?p=2504 http://haidut.me/?p=2504 Thu, 29 Feb 2024 18:42:18 +0000 00:00:51 false https://haidut.me/?p=2502 http://haidut.me/?p=2502 Thu, 29 Feb 2024 18:28:08 +0000 00:03:40 false https://haidut.me/?p=2499 http://haidut.me/?p=2499 Thu, 29 Feb 2024 16:59:48 +0000 00:01:47 false https://haidut.me/?p=2497 http://haidut.me/?p=2497 Thu, 29 Feb 2024 16:22:41 +0000 0.86; OR 1.86, 95% CI 1.01–3.44 compared with women with ratios in the 0.54–0.86 range), after adjustment for other covariates.”]]> 00:03:55 false https://haidut.me/?p=2493 http://haidut.me/?p=2493 Wed, 28 Feb 2024 18:34:40 +0000 00:01:15 false https://haidut.me/?p=2491 http://haidut.me/?p=2491 Wed, 28 Feb 2024 18:03:09 +0000 00:02:37 false https://haidut.me/?p=2489 http://haidut.me/?p=2489 Tue, 27 Feb 2024 19:20:13 +0000 00:02:30 false https://haidut.me/?p=2486 http://haidut.me/?p=2486 Tue, 27 Feb 2024 18:38:11 +0000 00:03:29 false https://haidut.me/?p=2484 http://haidut.me/?p=2484 Tue, 27 Feb 2024 17:40:03 +0000 00:00:51 false https://haidut.me/?p=2482 http://haidut.me/?p=2482 Mon, 26 Feb 2024 19:59:21 +0000 00:03:15 false https://haidut.me/?p=2480 http://haidut.me/?p=2480 Mon, 26 Feb 2024 19:25:36 +0000 00:02:18 false https://haidut.me/?p=2478 http://haidut.me/?p=2478 Fri, 23 Feb 2024 19:34:48 +0000 00:01:48 false https://haidut.me/?p=2476 http://haidut.me/?p=2476 Fri, 23 Feb 2024 19:07:45 +0000 25 kg/m2 were more likely to experience an enhanced increase in total lean mass and appendicular lean mass and an enhanced decrease in total fat with dietary niacin supplementation (Fig. Figure 1, link here, Figure 1, link here, Pinteraction<0.05). The remaining subgroup analyses of niacin intake and body mass components is shown in Fig. S2 A–E. The nonlinear relationship between niacin intake and body mass components is shown in Fig. Figure 2, link here, Figure 2, link here.” “…Our study found that daily dietary niacin intake was positively correlated with total lean mass, appendicular lean mass, total bone mineral content, and grip strength, and negatively correlated with sarcopenia risk, total fat and trunk fat. In addition, dietary niacin was negatively correlated with HOMA-IR and fasting insulin in participants with and without diabetes, and fasting blood glucose in participants without diabetes. To our knowledge, this is the first study to explore the relationship between dietary niacin and these outcomes of interest in a representative large cohort, while adjusting for a number of important covariates. Our results suggest that dietary niacin supplementation is an effective strategy for preventing and improving age-related muscle mass and strength loss. Higher dietary niacin intake improved muscle and fat distribution throughout the body, consistent with the findings of a previous randomized controlled trial. In this study involving overweight African-American women, niacin-bound chromium caused a significant loss of fat and sparing of muscle (22, link here). In our study, subgroup analyses also found that dietary niacin was more significantly associated with changes in muscle and fat in participants aged 50–60years, with hypertension and a BMI ≥25 kg/m2. A large prospective cohort study by Han et al. showed that the skeletal muscle mass index measured by bioelectrical impedance was inversely associated with the risk of hypertension in men, which may be related to insulin resistance because of decreased muscle mass, enhanced inflammatory and oxidative pathways, and increased arterial stiffness (23, link here, 24, link here). Moreover, aging and obesity can lead to a decrease in skeletal muscle mass and performance (25, link here, 26, link here). Therefore, in people with increased skeletal muscle damage and fat accumulation, the effect of dietary niacin is more significant. In our study, dietary niacin intake was also significantly positively correlated with grip strength. This finding may be explained by the significant enhancement of skeletal muscle mass that results from dietary niacin because there is a strong positive correlation between skeletal muscle mass and strength (27, link here). In addition, a cross-sectional study by Kim et al. showed that dietary niacin reduced levels of pro-inflammatory cytokines, including interleukin-6 (IL-6) and tumor necrosis factor -α (TNF-α), in the elderly, thereby improving diet quality and reducing sarcopenia (28, link here). Similar to the subgroup analysis of dietary niacin and skeletal muscle mass, dietary niacin had a stronger positive correlation with grip strength in subgroups with a BMI >25 kg/m2 or hypertension. This study found that in the range of daily dietary niacin intake in the general United States population (in the glucose homeostasis dataset, the maximum dosage of daily dietary niacin was 238 mg and the average dosage was 25 mg), dietary niacin was negatively correlated with HOMA-IR and fasting insulin, and in participants without diabetes, it was negatively correlated with fasting blood glucose. This means that niacin improves insulin resistance and glucose homeostasis at dietary doses. However, some previous studies have suggested that niacin promotes insulin resistance, which is a significant side effect when niacin is used as a lipid-lowering drug (29, link here, 30, link here). The reason for this inconsistent result lies in the dosage of niacin. When niacin is used as a lipid-lowering drug, its daily dose is 2–6 g, which far exceeds the daily dietary dose (31, link here).”]]> 00:02:04 false https://haidut.me/?p=2474 http://haidut.me/?p=2474 Fri, 23 Feb 2024 18:32:46 +0000 00:01:01 false https://haidut.me/?p=2472 http://haidut.me/?p=2472 Fri, 23 Feb 2024 18:01:52 +0000 00:01:47 false https://haidut.me/?p=2469 http://haidut.me/?p=2469 Wed, 21 Feb 2024 19:31:28 +0000 00:02:00 false https://haidut.me/?p=2466 http://haidut.me/?p=2466 Wed, 21 Feb 2024 18:58:24 +0000 00:02:51 false https://haidut.me/?p=2464 http://haidut.me/?p=2464 Wed, 21 Feb 2024 16:24:16 +0000 00:01:02 false https://haidut.me/?p=2462 http://haidut.me/?p=2462 Wed, 21 Feb 2024 16:05:51 +0000 00:01:00 false https://haidut.me/?p=2457 http://haidut.me/?p=2457 Tue, 20 Feb 2024 20:05:18 +0000 00:00:48 false https://haidut.me/?p=2455 http://haidut.me/?p=2455 Tue, 20 Feb 2024 19:45:44 +0000 00:01:03 false https://haidut.me/?p=2453 http://haidut.me/?p=2453 Tue, 20 Feb 2024 19:24:40 +0000 00:01:49 false https://haidut.me/?p=2450 http://haidut.me/?p=2450 Tue, 20 Feb 2024 18:59:56 +0000 00:01:33 false https://haidut.me/?p=2448 http://haidut.me/?p=2448 Tue, 20 Feb 2024 18:23:19 +0000 00:01:19 false https://haidut.me/?p=2446 http://haidut.me/?p=2446 Tue, 20 Feb 2024 17:24:16 +0000 00:01:56 false https://haidut.me/?p=2444 http://haidut.me/?p=2444 Tue, 20 Feb 2024 16:35:15 +0000 00:01:15 false https://haidut.me/?p=2441 http://haidut.me/?p=2441 Tue, 20 Feb 2024 15:10:29 +0000 00:03:27 false https://haidut.me/?p=2439 http://haidut.me/?p=2439 Tue, 20 Feb 2024 14:40:55 +0000 00:01:26 false https://haidut.me/?p=2437 http://haidut.me/?p=2437 Tue, 20 Feb 2024 14:20:53 +0000 00:01:42 false https://haidut.me/?p=2427 http://haidut.me/?p=2427 Sun, 17 Dec 2023 20:06:40 +0000 00:01:27 false https://haidut.me/?p=2425 http://haidut.me/?p=2425 Sun, 17 Dec 2023 18:31:48 +0000 00:02:10 false https://haidut.me/?p=2408 http://haidut.me/?p=2408 Tue, 05 Dec 2023 18:26:38 +0000 00:12:54 false https://haidut.me/?p=2401 http://haidut.me/?p=2401 Tue, 21 Nov 2023 18:10:36 +0000 00:03:54 false https://haidut.me/?p=2399 http://haidut.me/?p=2399 Fri, 17 Nov 2023 19:42:07 +0000 00:03:19 false https://haidut.me/?p=2396 http://haidut.me/?p=2396 Fri, 17 Nov 2023 19:02:26 +0000 00:01:57 false https://haidut.me/?p=2394 http://haidut.me/?p=2394 Fri, 17 Nov 2023 18:16:08 +0000 00:04:16 false https://haidut.me/?p=2390 http://haidut.me/?p=2390 Thu, 16 Nov 2023 19:12:14 +0000 00:04:22 false https://haidut.me/?p=2388 http://haidut.me/?p=2388 Thu, 02 Nov 2023 16:41:04 +0000 00:02:33 false https://haidut.me/?p=2383 http://haidut.me/?p=2383 Tue, 31 Oct 2023 15:55:43 +0000 00:04:55 false https://haidut.me/?p=2380 http://haidut.me/?p=2380 Mon, 30 Oct 2023 17:41:34 +0000 00:02:14 false https://haidut.me/?p=2378 http://haidut.me/?p=2378 Mon, 30 Oct 2023 16:57:26 +0000 cortisol) results in the unraveling of the entire pathological cascade. link here “…Our study suggests that the development of maladaptive inflammation and cognitive decline in ageing may not be a static or permanent condition, but rather that it can be reversed by inhibiting inflammatory PGE2 signalling through the myeloid EP2 receptor. First, we find that ageing is associated with a significant increase in pro-inflammatory PGE2 signalling in myeloid cells, which drives the sequestration of glucose into glycogen through the AKT–GSK3β–GYS1 pathway and away from the generation of ATP. Second, we uncover a fundamental vulnerability of ageing myeloid cells, in which they become dependent on glucose and are unable to use alternative energy sources to support mitochondrial respiration. These two mechanisms converge, leading to a reduction of glucose flux and the development of an energy-depleted state that drives pro-inflammatory immune responses. Third, by directing glucose towards the production of ATP, as opposed to glycogen storage, inhibition of myeloid EP2 in ageing cells reverts the polarization state to a more homeostatic anti-inflammatory state that prevents age-associated cognitive decline. We also demonstrate that peripheral EP2 blockade is sufficient to re-establish youthful immune homeostasis not only in the blood, but also in the brain, and to restore hippocampal function and plasticity in aged mice. The mechanisms underlying this rescue are probably distinct from those that underlie the effect of a brain-penetrant EP2 inhibitor that can directly target microglial EP2 signalling. Peripheral EP2 blockade may lead to changes in the composition of blood, components of which could beneficially affect the ageing cerebrovascular endothelium or penetrate the brain parenchyma to improve neuronal function. Finally, our findings are consistent with a feedforward loop involving the inflammatory COX-2–PGE2–EP2 cascade, in which increasing PGE2 signalling via the EP2 receptor induces additional COX-2 expression and activity, further amplifying downstream PGE2 generation and signalling24,38,39. Thus, inhibition of EP2-dependent changes in myeloid metabolism may represent a new approach to disorders of ageing, with greater specificity than the use of non-steroidal anti-inflammatory drugs that target COX-2 and COX-1 and suppress both beneficial and toxic prostaglandin signalling pathways40.”]]> 00:03:28 false https://haidut.me/?p=2376 http://haidut.me/?p=2376 Thu, 26 Oct 2023 17:34:07 +0000 00:04:11 false https://haidut.me/?p=2372 http://haidut.me/?p=2372 Mon, 23 Oct 2023 16:37:06 +0000 10 fold; p<0.001, PLSD Fisher’s test). Interestingly, SB-269970 completely blocked the enhancement of HTR following fluoxetine administration (p<0.001, PLSD Fisher’s test). These results therefore indicate that 5-HT7 receptor blockade did not facilitate the motoric component of the 5-HT syndrome but prevented the potentiating effect of fluoxetine.” “…These results showed an increase in anxiety-like behavior by postnatal exposure to the SSRI fluoxetine, but not with the 5-HT7 receptor agonist or the antagonist. In the FST, a significant effect of treatment was observed (F3,34=5.35; p<0.01, one-way ANOVA). The immobility duration was significantly enhanced by 32% in fluoxetine-exposed rats (p<0.05, PLSD Fisher’s test) during the neonatal period, but not in AS19- or SB-269970-exposed animals (Figure 7b, link here). Taken together, these results showed that neonatal exposure to the SSRI fluoxetine, but not to AS19 or SB-269970, produced anxiety- and depression-like behaviors in early adulthood of the rats.” “…It has also been reported that both pharmacological inhibition and genetic inactivation of 5-HT7 receptors induce antidepressant-like behavior in the mouse tail suspension test (Hedlund et al, 2005, link here; Bonaventure et al, 2007, link here; Sarkisyan et al, 2010, link here), as well as an antianxiety effect in the Vogel drinking test in rats, the elevated plus maze in rats, and in the four-plate test in mice (Wesolowska et al, 2006, link here). Interestingly, a dose of 2 mg/kg of SB-269970 had no detectable effect in the present study by itself, suggesting a lack of modification of 5-HT release as previously shown (Bonaventure et al, 2007, link here), it counteracted the anxiogenic-like effect of acute administration of fluoxetine in the illuminated open field (Figure 1, link here). Previous reports have shown that the SSRIs fluoxetine and citalopram display anxiogenic behaviors via the activation of 5-HT2C receptors as their effects were prevented by a 5-HT2C antagonist (Burghardt et al, 2007, link here; Dekeyne et al, 2000, link here; Greenwood et al, 2008, link here). Hence, it can be suggested that an enhanced activation of 5-HT2C, and also of 5-HT7, receptors might be a mechanism for the anxiogenic effects of SSRIs observed initially during treatment, based on the present results. These findings are of particular interest as several atypical antipsychotics, such as amisulpride and aripiprazole, which are potent 5-HT7 antagonist, are used in the treatment of mood disorders (Smeraldi, 1998, link here; Montgomery, 2002, link here; Na et al, 2008, link here: Berman et al, 2009, link here). Additionally, Abbas et al (2009), link here demonstrated that, in contrast to their wild-type littermates, 5-HT7 receptor knock-out mice did not respond to amisulpride in the FST and the tail suspension test. This indicates that 5-HT7 receptor antagonism may underly, at least in part, the antidepressant-like actions of antipsychotics such as amisulpride and aripiprazole (Abbas et al, 2009, link here; Sarkisyan et al, 2010, link here). Taken together, these data suggest that 5-HT7 receptor antagonists are of potential interest for the treatment of both depression and anxiety.” “…Overall, the multiple experimental approaches used herein provided important support for the hypothesis that 5-HT7 receptor antagonists may act as antidepressant (AD) agents with a rapid onset of action. Thus far, only one 5-HT7 receptor antagonist has been assessed in a clinical trial for moderate to severe depression (JNJ-18038683; Johnson and Johnson Pharmaceutical Research and Development). It is hoped that the present results will further stimulate the development of selective 5-HT7 receptor antagonists as a novel and potentially improved class of ADs.”]]> 00:01:36 false https://haidut.me/?p=2370 http://haidut.me/?p=2370 Mon, 23 Oct 2023 15:55:37 +0000 00:01:48 false https://haidut.me/?p=2366 http://haidut.me/?p=2366 Thu, 19 Oct 2023 16:36:46 +0000 00:02:51 false https://haidut.me/?p=2363 http://haidut.me/?p=2363 Thu, 19 Oct 2023 02:03:44 +0000 00:04:09 false https://haidut.me/?p=2360 http://haidut.me/?p=2360 Sun, 15 Oct 2023 21:03:34 +0000 60% in 20 lg mL1). Linoleic acid (28) with higher estrogenic activity (141.67% in 20 lg mL1) might act as a more potent estrogen agonist. Anisole (29) and aucubin (30) with estrogenic activities (100% in 20 lg mL1) could also be as potent estrogen agonists. Cinnamaldehyde (32) and benzaldehyde (38) possessed biphasic activity, which exhibited high estrogenic activity at low concentration, and the activity was reversed at high concentration. Maybe aldehyde group in the benzene ring was responsible for the biphasic activity.”]]> 00:01:43 false https://haidut.me/?p=2358 http://haidut.me/?p=2358 Fri, 13 Oct 2023 18:18:05 +0000 00:01:30 false https://haidut.me/?p=2355 http://haidut.me/?p=2355 Thu, 12 Oct 2023 16:24:10 +0000 00:05:43 false https://haidut.me/?p=2351 http://haidut.me/?p=2351 Tue, 10 Oct 2023 16:58:15 +0000 00:03:18 false https://haidut.me/?p=2349 http://haidut.me/?p=2349 Tue, 10 Oct 2023 15:03:08 +0000 00:02:42 false https://haidut.me/?p=2347 http://haidut.me/?p=2347 Fri, 06 Oct 2023 17:34:14 +0000 00:02:57 false https://haidut.me/?p=2345 http://haidut.me/?p=2345 Fri, 06 Oct 2023 16:46:54 +0000 00:01:39 false https://haidut.me/?p=2343 http://haidut.me/?p=2343 Fri, 06 Oct 2023 16:13:31 +0000 00:03:53 false https://haidut.me/?p=2341 http://haidut.me/?p=2341 Thu, 05 Oct 2023 17:41:21 +0000 00:02:10 false https://haidut.me/?p=2336 http://haidut.me/?p=2336 Thu, 05 Oct 2023 16:46:49 +0000 00:01:56 false https://haidut.me/?p=2334 http://haidut.me/?p=2334 Thu, 05 Oct 2023 14:54:52 +0000 00:01:54 false https://haidut.me/?p=2332 http://haidut.me/?p=2332 Wed, 04 Oct 2023 18:24:31 +0000 00:03:47 false https://haidut.me/?p=2330 http://haidut.me/?p=2330 Wed, 04 Oct 2023 16:08:47 +0000 00:02:55 false https://haidut.me/?p=2328 http://haidut.me/?p=2328 Tue, 03 Oct 2023 17:12:07 +0000 00:03:51 false https://haidut.me/?p=2326 http://haidut.me/?p=2326 Tue, 12 Sep 2023 17:42:12 +0000 00:05:45 false https://haidut.me/?p=2324 http://haidut.me/?p=2324 Fri, 08 Sep 2023 15:58:00 +0000 00:01:57 false https://haidut.me/?p=2322 http://haidut.me/?p=2322 Fri, 08 Sep 2023 15:15:59 +0000 00:01:18 false https://haidut.me/?p=2320 http://haidut.me/?p=2320 Thu, 07 Sep 2023 17:02:42 +0000 00:02:08 false https://haidut.me/?p=2316 http://haidut.me/?p=2316 Thu, 07 Sep 2023 16:37:41 +0000 00:01:58 false https://haidut.me/?p=2314 http://haidut.me/?p=2314 Wed, 06 Sep 2023 17:55:05 +0000 00:02:55 false https://haidut.me/?p=2312 http://haidut.me/?p=2312 Wed, 06 Sep 2023 17:10:58 +0000 00:03:29 false https://haidut.me/?p=2309 http://haidut.me/?p=2309 Tue, 05 Sep 2023 17:42:11 +0000 00:02:00 false https://haidut.me/?p=2307 http://haidut.me/?p=2307 Tue, 05 Sep 2023 17:18:29 +0000 00:01:19 false https://haidut.me/?p=2305 http://haidut.me/?p=2305 Tue, 05 Sep 2023 16:55:29 +0000 00:01:35 false https://haidut.me/?p=2302 http://haidut.me/?p=2302 Tue, 01 Aug 2023 05:49:05 +0000 00:05:54 false https://haidut.me/?p=2300 http://haidut.me/?p=2300 Thu, 20 Jul 2023 14:53:19 +0000 .05); however, mean changes in CSF p-tau181 (0.4 [±29.8] vs 10.4 [±41.8]) and total tau (8.4 [±228.6] vs 60.5 [±237.5]) favored nicotinamide.” “…On the primary outcome of change in CSF p-tau231, no statistically significant difference was observed on ANCOVA models (mean difference, 2.06 [SE, 4.03]; P = .61); although, greater mean declines were found in the nicotinamide arm (–4.7 [±14.5]) than placebo (–2.3 [±10.6]). Nicotinamide was associated with significantly less change on CDR-SB (estimate, –1.42 [SE, 0.65]; P = .03) but not on cognitive or functional assessments, explained through the Alzheimer’s Disease Assessment Scale-Cognitive Subscale 13 (estimate, –1.93 [SE, 1.93]; P = .32) and Alzheimer’s Disease Cooperative Study-Activities of Daily Living for Mild Cognitive Impairment scale (estimate, –3.10 [SE, 1.86]; P = .10).”]]> 00:02:01 false https://haidut.me/?p=2298 http://haidut.me/?p=2298 Tue, 18 Jul 2023 19:28:39 +0000 00:02:36 false https://haidut.me/?p=2296 http://haidut.me/?p=2296 Tue, 18 Jul 2023 19:05:19 +0000 00:01:15 false https://haidut.me/?p=2294 http://haidut.me/?p=2294 Tue, 18 Jul 2023 18:43:04 +0000 00:02:12 false https://haidut.me/?p=2291 http://haidut.me/?p=2291 Tue, 18 Jul 2023 18:08:30 +0000 00:01:43 false https://haidut.me/?p=2287 http://haidut.me/?p=2287 Fri, 14 Jul 2023 18:41:59 +0000 00:01:51 false https://haidut.me/?p=2285 http://haidut.me/?p=2285 Fri, 14 Jul 2023 18:19:03 +0000 00:03:05 false https://haidut.me/?p=2283 http://haidut.me/?p=2283 Fri, 14 Jul 2023 17:43:15 +0000 00:01:56 false https://haidut.me/?p=2278 http://haidut.me/?p=2278 Wed, 28 Jun 2023 18:19:01 +0000 00:01:24 false https://haidut.me/?p=2276 http://haidut.me/?p=2276 Wed, 28 Jun 2023 17:52:32 +0000 00:02:09 false https://haidut.me/?p=2274 http://haidut.me/?p=2274 Wed, 28 Jun 2023 17:21:30 +0000 500 IU daily) had no such effect. Additionally, vitamin E supplementation had a positive effect on athletes’ CK concentrations while having no positive impact on non-athlete participants.” “…Vitamin E is made up of two broad members – tocopherols and tocotrienols. Tocotrienols have also been shown to improve endurance capacity as indicated by a longer duration of swimming and reduce exercise induced oxidative stress. As such, vitamin E supplementation has demonstrated potential in mitigating exercise-induced muscle damage. By scavenging free radicals and reducing lipid peroxidation, full spectrum vitamin E (d-mixed tocopherols + d-mixed tocotrienols) may help minimise oxidative damage to muscle tissues. This effect is particularly relevant for endurance athletes who engage in prolonged, strenuous and repetitive exercise, as they are more prone to muscle damage caused by oxidative stress,” said Dr Ariati Aris, Scientific Affairs Specialist at PhytoGaia.”]]> 00:00:54 false https://haidut.me/?p=2271 http://haidut.me/?p=2271 Wed, 28 Jun 2023 16:56:25 +0000 00:02:11 false https://haidut.me/?p=2269 http://haidut.me/?p=2269 Wed, 28 Jun 2023 16:15:47 +0000 00:02:46 false https://haidut.me/?p=2267 http://haidut.me/?p=2267 Wed, 21 Jun 2023 18:45:57 +0000 00:01:09 false https://haidut.me/?p=2265 http://haidut.me/?p=2265 Wed, 21 Jun 2023 18:08:01 +0000 00:02:47 false https://haidut.me/?p=2254 http://haidut.me/?p=2254 Fri, 26 May 2023 15:11:19 +0000 00:03:32 false https://haidut.me/?p=2250 http://haidut.me/?p=2250 Fri, 26 May 2023 03:24:38 +0000 00:02:11 false https://haidut.me/?p=2245 http://haidut.me/?p=2245 Fri, 26 May 2023 02:19:28 +0000 00:04:11 false https://haidut.me/?p=2242 http://haidut.me/?p=2242 Thu, 25 May 2023 18:28:20 +0000 00:02:04 false https://haidut.me/?p=2239 http://haidut.me/?p=2239 Wed, 24 May 2023 17:33:05 +0000 00:04:09 false https://haidut.me/?p=2232 http://haidut.me/?p=2232 Sun, 21 May 2023 17:41:18 +0000 00:02:56 false https://haidut.me/?p=2229 http://haidut.me/?p=2229 Thu, 18 May 2023 18:16:51 +0000 00:00:43 false https://haidut.me/?p=2227 http://haidut.me/?p=2227 Thu, 18 May 2023 18:00:31 +0000 00:02:07 false https://haidut.me/?p=2225 http://haidut.me/?p=2225 Thu, 18 May 2023 17:27:27 +0000 00:02:30 false https://haidut.me/?p=2222 http://haidut.me/?p=2222 Thu, 18 May 2023 16:02:20 +0000 00:00:33 false https://haidut.me/?p=2220 http://haidut.me/?p=2220 Thu, 18 May 2023 15:25:58 +0000 00:01:18 false https://haidut.me/?p=2218 http://haidut.me/?p=2218 Wed, 17 May 2023 19:04:01 +0000 00:01:57 false https://haidut.me/?p=2214 http://haidut.me/?p=2214 Wed, 17 May 2023 18:28:36 +0000 00:03:38 false https://haidut.me/?p=2211 http://haidut.me/?p=2211 Wed, 17 May 2023 17:37:53 +0000 00:01:50 false https://haidut.me/?p=2206 http://haidut.me/?p=2206 Fri, 12 May 2023 17:21:08 +0000 00:02:09 false https://haidut.me/?p=2204 http://haidut.me/?p=2204 Fri, 12 May 2023 04:31:07 +0000 00:01:24 false https://haidut.me/?p=2202 http://haidut.me/?p=2202 Fri, 12 May 2023 03:58:12 +0000 00:03:03 false https://haidut.me/?p=2200 http://haidut.me/?p=2200 Fri, 12 May 2023 03:19:37 +0000 00:01:52 false https://haidut.me/?p=2198 http://haidut.me/?p=2198 Thu, 11 May 2023 17:44:59 +0000 00:02:31 false https://haidut.me/?p=2195 http://haidut.me/?p=2195 Thu, 11 May 2023 17:01:22 +0000 00:02:26 false https://haidut.me/?p=2191 http://haidut.me/?p=2191 Wed, 10 May 2023 04:40:41 +0000 00:04:36 false https://haidut.me/?p=2189 http://haidut.me/?p=2189 Wed, 10 May 2023 03:31:40 +0000 00:03:55 false https://haidut.me/?p=2187 http://haidut.me/?p=2187 Wed, 10 May 2023 02:37:09 +0000 00:01:34 false https://haidut.me/?p=2184 http://haidut.me/?p=2184 Wed, 10 May 2023 01:55:26 +0000 00:01:50 false https://haidut.me/?p=2178 http://haidut.me/?p=2178 Fri, 03 Mar 2023 17:35:16 +0000 00:03:21 false https://haidut.me/?p=2176 http://haidut.me/?p=2176 Fri, 03 Mar 2023 16:56:55 +0000 00:02:43 false https://haidut.me/?p=2174 http://haidut.me/?p=2174 Fri, 03 Mar 2023 16:27:01 +0000 00:00:42 false https://haidut.me/?p=2172 http://haidut.me/?p=2172 Fri, 03 Mar 2023 16:12:58 +0000 00:01:10 false https://haidut.me/?p=2170 http://haidut.me/?p=2170 Wed, 01 Mar 2023 16:17:38 +0000 00:02:33 false https://haidut.me/?p=2168 http://haidut.me/?p=2168 Tue, 28 Feb 2023 20:26:05 +0000 00:01:44 false https://haidut.me/?p=2166 http://haidut.me/?p=2166 Tue, 28 Feb 2023 19:42:36 +0000 00:00:49 false https://haidut.me/?p=2162 http://haidut.me/?p=2162 Tue, 28 Feb 2023 19:13:38 +0000 00:02:06 false https://haidut.me/?p=2160 http://haidut.me/?p=2160 Tue, 28 Feb 2023 18:19:36 +0000 00:01:37 false https://haidut.me/?p=2158 http://haidut.me/?p=2158 Tue, 28 Feb 2023 17:48:32 +0000 00:00:58 false https://haidut.me/?p=2156 http://haidut.me/?p=2156 Fri, 24 Feb 2023 19:31:03 +0000 00:03:12 false https://haidut.me/?p=2151 http://haidut.me/?p=2151 Wed, 22 Feb 2023 19:09:42 +0000 00:03:39 false https://haidut.me/?p=2149 http://haidut.me/?p=2149 Wed, 22 Feb 2023 18:23:58 +0000 00:00:43 false https://haidut.me/?p=2147 http://haidut.me/?p=2147 Wed, 22 Feb 2023 18:14:47 +0000 00:01:13 false https://haidut.me/?p=2144 http://haidut.me/?p=2144 Tue, 21 Feb 2023 05:06:56 +0000 00:04:13 false https://haidut.me/?p=2138 http://haidut.me/?p=2138 Sat, 18 Feb 2023 01:47:04 +0000 00:02:21 false https://haidut.me/?p=2136 http://haidut.me/?p=2136 Fri, 17 Feb 2023 02:56:29 +0000 00:00:51 false https://haidut.me/?p=2134 http://haidut.me/?p=2134 Fri, 17 Feb 2023 02:41:26 +0000 00:02:43 false https://haidut.me/?p=2132 http://haidut.me/?p=2132 Fri, 17 Feb 2023 02:14:34 +0000 00:01:13 false https://haidut.me/?p=2128 http://haidut.me/?p=2128 Sun, 12 Feb 2023 23:02:20 +0000 00:00:59 false https://haidut.me/?p=2124 http://haidut.me/?p=2124 Sun, 12 Feb 2023 22:33:42 +0000 00:00:40 false https://haidut.me/?p=2122 http://haidut.me/?p=2122 Sun, 12 Feb 2023 22:14:59 +0000 00:02:55 false https://haidut.me/?p=2120 http://haidut.me/?p=2120 Sun, 12 Feb 2023 21:43:07 +0000 00:03:18 false https://haidut.me/?p=2118 http://haidut.me/?p=2118 Sun, 12 Feb 2023 21:13:13 +0000 00:02:02 false https://haidut.me/?p=2116 http://haidut.me/?p=2116 Sun, 12 Feb 2023 19:28:33 +0000 00:01:32 false https://haidut.me/?p=2114 http://haidut.me/?p=2114 Sun, 12 Feb 2023 19:01:32 +0000 00:01:27 false https://haidut.me/?p=2112 http://haidut.me/?p=2112 Sun, 12 Feb 2023 18:44:37 +0000 00:03:56 false https://haidut.me/?p=2104 http://haidut.me/?p=2104 Wed, 21 Dec 2022 19:02:30 +0000 00:02:55 false https://haidut.me/?p=2102 http://haidut.me/?p=2102 Wed, 21 Dec 2022 18:25:43 +0000 00:01:49 false https://haidut.me/?p=2099 http://haidut.me/?p=2099 Wed, 21 Dec 2022 01:19:04 +0000 00:01:02 false https://haidut.me/?p=2095 http://haidut.me/?p=2095 Wed, 21 Dec 2022 00:42:53 +0000 00:02:14 false https://haidut.me/?p=2093 http://haidut.me/?p=2093 Wed, 21 Dec 2022 00:17:09 +0000 00:01:29 false https://haidut.me/?p=2090 http://haidut.me/?p=2090 Fri, 16 Dec 2022 20:28:35 +0000 00:04:43 false https://haidut.me/?p=2088 http://haidut.me/?p=2088 Fri, 16 Dec 2022 19:30:15 +0000 00:00:37 false https://haidut.me/?p=2084 http://haidut.me/?p=2084 Fri, 16 Dec 2022 19:12:29 +0000 00:02:15 false https://haidut.me/?p=2080 http://haidut.me/?p=2080 Fri, 16 Dec 2022 17:33:37 +0000 00:03:11 false https://haidut.me/?p=2077 http://haidut.me/?p=2077 Fri, 16 Dec 2022 17:00:05 +0000 00:01:21 false https://haidut.me/?p=2075 http://haidut.me/?p=2075 Fri, 16 Dec 2022 16:32:47 +0000 00:02:18 false https://haidut.me/?p=2069 http://haidut.me/?p=2069 Wed, 30 Nov 2022 18:07:34 +0000 00:02:56 false https://haidut.me/?p=2064 http://haidut.me/?p=2064 Fri, 25 Nov 2022 19:07:06 +0000 00:01:41 false https://haidut.me/?p=2062 http://haidut.me/?p=2062 Fri, 25 Nov 2022 18:01:13 +0000 00:02:06 false https://haidut.me/?p=2058 http://haidut.me/?p=2058 Wed, 16 Nov 2022 20:31:41 +0000 20ng/mL compared with <20ng/mL was linked to an estimated 9.7% reduction in fibroid development. 3. A rough 22% reduction in incidence was linked to serum 25(OH)D levels below ≥30ng/mL when compared to levels over >30ng/mL, which is close to the unadjusted estimate of 0.84. 4. Additionally, fibroid reduction increased by 32% in the group with >30ng/mL. In conclusion, concentrations of 25(OH)D greater than 20 ng/mL were linked to slower fibroid development. Results of research that looked at 25(OH)D concentrations >30 ng/mL suggested that fibroid removal was more likely and that the incidence of fibroid growth may have decreased.”]]> 00:02:24 false https://haidut.me/?p=2056 http://haidut.me/?p=2056 Wed, 16 Nov 2022 19:43:38 +0000 00:03:21 false https://haidut.me/?p=2047 http://haidut.me/?p=2047 Wed, 09 Nov 2022 03:15:05 +0000 00:02:23 false https://haidut.me/?p=2045 http://haidut.me/?p=2045 Sun, 06 Nov 2022 16:58:58 +0000 00:02:02 false https://haidut.me/?p=2043 http://haidut.me/?p=2043 Sun, 06 Nov 2022 16:34:13 +0000 00:00:46 false https://haidut.me/?p=2041 http://haidut.me/?p=2041 Thu, 03 Nov 2022 15:20:17 +0000 00:01:05 false https://haidut.me/?p=2039 http://haidut.me/?p=2039 Wed, 02 Nov 2022 18:05:46 +0000 00:02:01 false https://haidut.me/?p=2037 http://haidut.me/?p=2037 Wed, 02 Nov 2022 17:40:27 +0000 00:00:58 false https://haidut.me/?p=2035 http://haidut.me/?p=2035 Wed, 02 Nov 2022 17:28:11 +0000 00:03:00 false https://haidut.me/?p=2033 http://haidut.me/?p=2033 Wed, 02 Nov 2022 16:51:18 +0000 00:00:50 false https://haidut.me/?p=2031 http://haidut.me/?p=2031 Wed, 02 Nov 2022 16:33:06 +0000 00:01:24 false https://haidut.me/?p=2023 http://haidut.me/?p=2023 Thu, 27 Oct 2022 01:58:37 +0000 00:01:25 false https://haidut.me/?p=2019 http://haidut.me/?p=2019 Wed, 26 Oct 2022 17:55:19 +0000 0.05). Moreover, women showed no significant associations of total testosterone, androstenedione, DHEA, and DHEAS, with the odds of NAFLD (all P > 0.05)….Serum total testosterone was independently associated with the risk of NAFLD among men with T2DM. This study highlights the potential role of testosterone as a risk factor for NAFLD in patients with T2DM.” link here “…Results: No randomized-controlled trials that met the inclusion criteria were identified. One study was conducted in the general population and reported an increased risk of incident CKD with low vs normal testosterone (hazard ratio (HR): 1.38, 95% CI: 1.05;1.80). Seven studies were conducted in men with CKD and included testosterone as determinant, of which six could be meta-analyzed. Low testosterone was associated with an increased risk of all-cause mortality and CV events (pooled HR: 1.98, 95% CI: 1.36;2.89; pooled HR of 2.40, 95% CI: 1.22;4.71, respectively). Two studies showed an increased risk of all-cause mortality with decreased dehydroepiandrosterone sulfate (DHEAS) in men with CKD; results regarding CV events were conflicting…Although literature is scarce, evidence suggests that lower testosterone may increase CKD risk in the general population and risk of all-cause mortality and CV events in men with CKD. Whether testosterone supplementation could prevent these potential detrimental outcomes should be determined in future intervention studies.”]]> 00:01:34 false https://haidut.me/?p=2015 http://haidut.me/?p=2015 Wed, 26 Oct 2022 17:27:50 +0000 00:02:07 false https://haidut.me/?p=2013 http://haidut.me/?p=2013 Wed, 26 Oct 2022 16:50:35 +0000 00:02:56 false https://haidut.me/?p=2011 http://haidut.me/?p=2011 Tue, 25 Oct 2022 18:43:20 +0000 00:01:42 false https://haidut.me/?p=2009 http://haidut.me/?p=2009 Tue, 25 Oct 2022 18:14:51 +0000 00:02:13 false https://haidut.me/?p=2007 http://haidut.me/?p=2007 Tue, 25 Oct 2022 17:49:35 +0000 00:01:06 false https://haidut.me/?p=2005 http://haidut.me/?p=2005 Tue, 25 Oct 2022 17:19:36 +0000 00:01:05 false https://haidut.me/?p=2003 http://haidut.me/?p=2003 Tue, 25 Oct 2022 17:03:18 +0000 00:00:52 false https://haidut.me/?p=2001 http://haidut.me/?p=2001 Tue, 25 Oct 2022 16:50:05 +0000 00:00:33 false https://haidut.me/?p=1999 http://haidut.me/?p=1999 Tue, 25 Oct 2022 16:43:05 +0000 00:03:00 false https://haidut.me/?p=1997 http://haidut.me/?p=1997 Tue, 25 Oct 2022 16:09:11 +0000 00:01:15 false https://haidut.me/?p=1994 http://haidut.me/?p=1994 Fri, 14 Oct 2022 17:16:05 +0000 00:04:56 false https://haidut.me/?p=1992 http://haidut.me/?p=1992 Fri, 30 Sep 2022 17:50:53 +0000 00:04:25 false https://haidut.me/?p=1989 http://haidut.me/?p=1989 Tue, 27 Sep 2022 17:40:00 +0000 00:04:14 false https://haidut.me/?p=1985 http://haidut.me/?p=1985 Tue, 20 Sep 2022 18:38:52 +0000 00:03:36 false https://haidut.me/?p=1980 http://haidut.me/?p=1980 Tue, 20 Sep 2022 17:32:32 +0000 00:00:56 false https://haidut.me/?p=1978 http://haidut.me/?p=1978 Tue, 20 Sep 2022 17:22:25 +0000 00:01:52 false https://haidut.me/?p=1976 http://haidut.me/?p=1976 Mon, 19 Sep 2022 17:24:23 +0000 00:02:15 false https://haidut.me/?p=1974 http://haidut.me/?p=1974 Mon, 19 Sep 2022 16:49:26 +0000 00:01:12 false https://haidut.me/?p=1972 http://haidut.me/?p=1972 Mon, 19 Sep 2022 16:17:00 +0000 00:01:13 false https://haidut.me/?p=1970 http://haidut.me/?p=1970 Fri, 26 Aug 2022 19:57:58 +0000 00:01:59 false https://haidut.me/?p=1967 http://haidut.me/?p=1967 Fri, 26 Aug 2022 19:42:37 +0000 00:01:26 false https://haidut.me/?p=1965 http://haidut.me/?p=1965 Fri, 26 Aug 2022 19:25:20 +0000 00:01:24 false https://haidut.me/?p=1962 http://haidut.me/?p=1962 Fri, 26 Aug 2022 19:11:44 +0000 00:01:28 false https://haidut.me/?p=1959 http://haidut.me/?p=1959 Fri, 26 Aug 2022 18:54:11 +0000 00:00:52 false https://haidut.me/?p=1955 http://haidut.me/?p=1955 Sat, 23 Jul 2022 02:48:25 +0000 00:03:46 false https://haidut.me/?p=1953 http://haidut.me/?p=1953 Fri, 22 Jul 2022 17:51:02 +0000 00:01:22 false https://haidut.me/?p=1950 http://haidut.me/?p=1950 Thu, 21 Jul 2022 18:45:23 +0000 00:01:19 false https://haidut.me/?p=1947 http://haidut.me/?p=1947 Fri, 15 Jul 2022 17:15:38 +0000 00:02:00 false https://haidut.me/?p=1942 http://haidut.me/?p=1942 Fri, 15 Jul 2022 15:13:50 +0000 00:02:20 false https://haidut.me/?p=1937 http://haidut.me/?p=1937 Fri, 15 Jul 2022 01:58:31 +0000 00:04:57 false https://haidut.me/?p=1933 http://haidut.me/?p=1933 Thu, 14 Jul 2022 15:31:56 +0000 00:02:25 false https://haidut.me/?p=1931 http://haidut.me/?p=1931 Wed, 13 Jul 2022 17:29:01 +0000 00:00:35 false https://haidut.me/?p=1926 http://haidut.me/?p=1926 Wed, 13 Jul 2022 17:12:56 +0000 00:02:04 false https://haidut.me/?p=1923 http://haidut.me/?p=1923 Wed, 13 Jul 2022 16:53:42 +0000 00:01:52 false https://haidut.me/?p=1921 http://haidut.me/?p=1921 Wed, 13 Jul 2022 16:16:05 +0000 00:01:18 false https://haidut.me/?p=1919 http://haidut.me/?p=1919 Tue, 12 Jul 2022 19:19:29 +0000 00:01:52 false https://haidut.me/?p=1917 http://haidut.me/?p=1917 Tue, 12 Jul 2022 18:20:29 +0000 00:00:29 false https://haidut.me/?p=1914 http://haidut.me/?p=1914 Tue, 12 Jul 2022 17:31:23 +0000 00:01:03 false https://haidut.me/?p=1911 http://haidut.me/?p=1911 Tue, 12 Jul 2022 16:56:51 +0000 00:03:08 false https://haidut.me/?p=1905 http://haidut.me/?p=1905 Thu, 07 Jul 2022 19:23:56 +0000 00:03:17 false https://haidut.me/?p=1901 http://haidut.me/?p=1901 Thu, 23 Jun 2022 19:08:19 +0000 00:04:07 false https://haidut.me/?p=1897 http://haidut.me/?p=1897 Wed, 22 Jun 2022 18:59:22 +0000 00:01:34 false https://haidut.me/?p=1895 http://haidut.me/?p=1895 Wed, 22 Jun 2022 18:39:10 +0000 00:00:53 false https://haidut.me/?p=1892 http://haidut.me/?p=1892 Wed, 22 Jun 2022 18:18:22 +0000 00:01:45 false https://haidut.me/?p=1890 http://haidut.me/?p=1890 Tue, 21 Jun 2022 19:03:13 +0000 00:00:56 false https://haidut.me/?p=1888 http://haidut.me/?p=1888 Tue, 21 Jun 2022 18:30:16 +0000 00:01:30 false https://haidut.me/?p=1885 http://haidut.me/?p=1885 Tue, 21 Jun 2022 18:02:36 +0000 00:02:33 false https://haidut.me/?p=1882 http://haidut.me/?p=1882 Thu, 16 Jun 2022 13:34:36 +0000 00:00:37 false https://haidut.me/?p=1879 http://haidut.me/?p=1879 Tue, 14 Jun 2022 17:36:24 +0000 00:01:13 false https://haidut.me/?p=1877 http://haidut.me/?p=1877 Tue, 14 Jun 2022 17:07:30 +0000 00:01:42 false https://haidut.me/?p=1874 http://haidut.me/?p=1874 Tue, 14 Jun 2022 16:32:01 +0000 00:01:32 false https://haidut.me/?p=1872 http://haidut.me/?p=1872 Tue, 14 Jun 2022 16:02:57 +0000 00:00:51 false https://haidut.me/?p=1869 http://haidut.me/?p=1869 Thu, 02 Jun 2022 18:16:07 +0000 00:03:01 false https://haidut.me/?p=1866 http://haidut.me/?p=1866 Tue, 31 May 2022 17:49:17 +0000 00:02:07 false https://haidut.me/?p=1858 http://haidut.me/?p=1858 Sat, 28 May 2022 03:31:32 +0000 00:11:31 false https://haidut.me/?p=1855 http://haidut.me/?p=1855 Tue, 24 May 2022 18:57:20 +0000 00:02:26 false https://haidut.me/?p=1853 http://haidut.me/?p=1853 Tue, 24 May 2022 18:32:00 +0000 00:02:19 false https://haidut.me/?p=1850 http://haidut.me/?p=1850 Tue, 24 May 2022 17:45:18 +0000 00:01:13 false https://haidut.me/?p=1848 http://haidut.me/?p=1848 Tue, 24 May 2022 17:16:46 +0000 00:03:27 false https://haidut.me/?p=1846 http://haidut.me/?p=1846 Tue, 24 May 2022 16:29:03 +0000 00:00:48 false https://haidut.me/?p=1844 http://haidut.me/?p=1844 Wed, 18 May 2022 16:20:29 +0000 00:01:06 false https://haidut.me/?p=1842 http://haidut.me/?p=1842 Fri, 13 May 2022 17:49:58 +0000 00:01:20 false https://haidut.me/?p=1838 http://haidut.me/?p=1838 Fri, 13 May 2022 17:25:29 +0000 00:00:46 false https://haidut.me/?p=1835 http://haidut.me/?p=1835 Tue, 10 May 2022 14:50:08 +0000 00:01:41 false https://haidut.me/?p=1833 http://haidut.me/?p=1833 Tue, 10 May 2022 13:48:24 +0000 00:00:44 false https://haidut.me/?p=1828 http://haidut.me/?p=1828 Mon, 09 May 2022 18:07:17 +0000 00:02:40 false https://haidut.me/?p=1825 http://haidut.me/?p=1825 Mon, 09 May 2022 16:57:40 +0000 00:01:06 false https://haidut.me/?p=1822 http://haidut.me/?p=1822 Mon, 09 May 2022 16:42:47 +0000 00:01:32 false https://haidut.me/?p=1820 http://haidut.me/?p=1820 Fri, 06 May 2022 00:01:49 +0000 00:01:49 false https://haidut.me/?p=1818 http://haidut.me/?p=1818 Thu, 05 May 2022 18:44:13 +0000 00:01:42 false https://haidut.me/?p=1815 http://haidut.me/?p=1815 Wed, 27 Apr 2022 17:51:51 +0000 00:01:53 false https://haidut.me/?p=1813 http://haidut.me/?p=1813 Wed, 27 Apr 2022 17:18:30 +0000 00:01:29 false https://haidut.me/?p=1810 http://haidut.me/?p=1810 Wed, 06 Apr 2022 13:55:46 +0000 00:02:05 false https://haidut.me/?p=1808 http://haidut.me/?p=1808 Fri, 01 Apr 2022 16:21:25 +0000 00:03:05 false https://haidut.me/?p=1806 http://haidut.me/?p=1806 Thu, 31 Mar 2022 18:25:31 +0000 00:00:51 false https://haidut.me/?p=1804 http://haidut.me/?p=1804 Thu, 31 Mar 2022 18:10:23 +0000 00:01:39 false https://haidut.me/?p=1801 http://haidut.me/?p=1801 Thu, 31 Mar 2022 17:52:36 +0000 00:01:18 false https://haidut.me/?p=1798 http://haidut.me/?p=1798 Thu, 31 Mar 2022 17:27:37 +0000 00:00:48 false https://haidut.me/?p=1795 http://haidut.me/?p=1795 Thu, 31 Mar 2022 16:59:11 +0000 00:00:57 false https://haidut.me/?p=1792 http://haidut.me/?p=1792 Thu, 31 Mar 2022 16:34:05 +0000 00:02:40 false https://haidut.me/?p=1790 http://haidut.me/?p=1790 Thu, 31 Mar 2022 15:55:14 +0000 00:03:43 false https://haidut.me/?p=1788 http://haidut.me/?p=1788 Thu, 31 Mar 2022 00:51:38 +0000 00:00:55 false https://haidut.me/?p=1786 http://haidut.me/?p=1786 Thu, 31 Mar 2022 00:39:04 +0000 00:01:04 false https://haidut.me/?p=1784 http://haidut.me/?p=1784 Thu, 31 Mar 2022 00:22:04 +0000 00:01:51 false https://haidut.me/?p=1782 http://haidut.me/?p=1782 Thu, 31 Mar 2022 00:00:55 +0000 00:01:35 false https://haidut.me/?p=1778 http://haidut.me/?p=1778 Wed, 30 Mar 2022 18:56:25 +0000 00:00:49 false https://haidut.me/?p=1775 http://haidut.me/?p=1775 Wed, 30 Mar 2022 18:41:29 +0000 00:02:11 false https://haidut.me/?p=1771 http://haidut.me/?p=1771 Wed, 30 Mar 2022 18:00:04 +0000 00:01:19 false https://haidut.me/?p=1768 http://haidut.me/?p=1768 Wed, 30 Mar 2022 17:17:11 +0000 00:01:15 false https://haidut.me/?p=1766 http://haidut.me/?p=1766 Wed, 30 Mar 2022 16:54:54 +0000 00:01:29 false https://haidut.me/?p=1763 http://haidut.me/?p=1763 Fri, 11 Mar 2022 19:39:17 +0000 00:02:03 false https://haidut.me/?p=1761 http://haidut.me/?p=1761 Thu, 10 Feb 2022 17:41:21 +0000 00:03:34 false https://haidut.me/?p=1755 http://haidut.me/?p=1755 Wed, 09 Feb 2022 21:14:30 +0000 00:03:13 false https://haidut.me/?p=1753 http://haidut.me/?p=1753 Wed, 09 Feb 2022 20:35:32 +0000 00:08:15 false https://haidut.me/?p=1748 http://haidut.me/?p=1748 Tue, 08 Feb 2022 18:53:03 +0000 00:01:27 false https://haidut.me/?p=1746 http://haidut.me/?p=1746 Tue, 08 Feb 2022 18:26:49 +0000 00:01:37 false https://haidut.me/?p=1740 http://haidut.me/?p=1740 Tue, 01 Feb 2022 00:36:49 +0000 00:08:21 false https://haidut.me/?p=1738 http://haidut.me/?p=1738 Fri, 28 Jan 2022 19:54:40 +0000 00:01:08 false https://haidut.me/?p=1736 http://haidut.me/?p=1736 Fri, 28 Jan 2022 19:22:06 +0000 00:01:47 false https://haidut.me/?p=1733 http://haidut.me/?p=1733 Tue, 18 Jan 2022 14:59:26 +0000 00:01:18 false https://haidut.me/?p=1729 http://haidut.me/?p=1729 Fri, 14 Jan 2022 01:28:04 +0000 00:01:26 false https://haidut.me/?p=1726 http://haidut.me/?p=1726 Wed, 12 Jan 2022 14:58:25 +0000 00:00:56 false https://haidut.me/?p=1723 http://haidut.me/?p=1723 Tue, 11 Jan 2022 17:07:20 +0000 00:01:01 false https://haidut.me/?p=1721 http://haidut.me/?p=1721 Tue, 11 Jan 2022 16:49:22 +0000 00:00:54 false https://haidut.me/?p=1719 http://haidut.me/?p=1719 Tue, 11 Jan 2022 16:28:24 +0000 00:01:10 false https://haidut.me/?p=1717 http://haidut.me/?p=1717 Tue, 11 Jan 2022 16:04:54 +0000 00:03:07 false https://haidut.me/?p=1715 http://haidut.me/?p=1715 Tue, 11 Jan 2022 15:30:20 +0000 00:00:46 false https://haidut.me/?p=1713 http://haidut.me/?p=1713 Tue, 11 Jan 2022 15:13:44 +0000 00:01:15 false https://haidut.me/?p=1711 http://haidut.me/?p=1711 Tue, 21 Dec 2021 20:13:41 +0000 00:04:31 false https://haidut.me/?p=1707 http://haidut.me/?p=1707 Fri, 10 Dec 2021 19:18:06 +0000 00:03:31 false https://haidut.me/?p=1705 http://haidut.me/?p=1705 Fri, 10 Dec 2021 15:42:54 +0000 00:01:25 false https://haidut.me/?p=1703 http://haidut.me/?p=1703 Fri, 10 Dec 2021 15:20:13 +0000 00:02:43 false https://haidut.me/?p=1701 http://haidut.me/?p=1701 Thu, 09 Dec 2021 18:56:51 +0000 00:01:09 false https://haidut.me/?p=1699 http://haidut.me/?p=1699 Thu, 09 Dec 2021 18:29:38 +0000 00:01:09 false https://haidut.me/?p=1696 http://haidut.me/?p=1696 Thu, 09 Dec 2021 17:32:20 +0000 00:01:22 false https://haidut.me/?p=1693 http://haidut.me/?p=1693 Thu, 09 Dec 2021 17:07:29 +0000 00:03:13 false https://haidut.me/?p=1687 http://haidut.me/?p=1687 Thu, 09 Dec 2021 16:32:52 +0000 00:04:35 false https://haidut.me/?p=1684 http://haidut.me/?p=1684 Tue, 09 Nov 2021 17:49:54 +0000 00:04:56 false https://haidut.me/?p=1680 http://haidut.me/?p=1680 Sun, 07 Nov 2021 23:50:15 +0000 00:02:29 false https://haidut.me/?p=1677 http://haidut.me/?p=1677 Sat, 06 Nov 2021 23:03:14 +0000 00:05:42 false https://haidut.me/?p=1670 http://haidut.me/?p=1670 Thu, 21 Oct 2021 17:52:42 +0000 00:02:16 false https://haidut.me/?p=1668 http://haidut.me/?p=1668 Thu, 21 Oct 2021 17:06:25 +0000 00:02:49 false https://haidut.me/?p=1665 http://haidut.me/?p=1665 Wed, 20 Oct 2021 17:58:31 +0000 00:01:41 false https://haidut.me/?p=1662 http://haidut.me/?p=1662 Wed, 20 Oct 2021 17:34:11 +0000 00:01:15 false https://haidut.me/?p=1660 http://haidut.me/?p=1660 Wed, 20 Oct 2021 17:15:28 +0000 00:00:52 false https://haidut.me/?p=1658 http://haidut.me/?p=1658 Wed, 20 Oct 2021 17:00:16 +0000 00:00:59 false https://haidut.me/?p=1655 http://haidut.me/?p=1655 Wed, 20 Oct 2021 16:44:50 +0000 00:01:25 false https://haidut.me/?p=1653 http://haidut.me/?p=1653 Wed, 20 Oct 2021 16:18:57 +0000 00:00:42 false https://haidut.me/?p=1649 http://haidut.me/?p=1649 Wed, 20 Oct 2021 16:04:00 +0000 00:02:11 false https://haidut.me/?p=1647 http://haidut.me/?p=1647 Thu, 30 Sep 2021 17:58:13 +0000 00:00:57 false https://haidut.me/?p=1645 http://haidut.me/?p=1645 Thu, 30 Sep 2021 17:41:33 +0000 00:02:05 false https://haidut.me/?p=1643 http://haidut.me/?p=1643 Thu, 30 Sep 2021 17:05:27 +0000 00:01:47 false https://haidut.me/?p=1640 http://haidut.me/?p=1640 Fri, 24 Sep 2021 17:13:44 +0000 00:01:43 false https://haidut.me/?p=1636 http://haidut.me/?p=1636 Fri, 24 Sep 2021 16:43:46 +0000 00:02:09 false https://haidut.me/?p=1634 http://haidut.me/?p=1634 Wed, 22 Sep 2021 15:41:31 +0000 00:03:01 false https://haidut.me/?p=1632 http://haidut.me/?p=1632 Fri, 17 Sep 2021 16:53:13 +0000 00:01:09 false https://haidut.me/?p=1627 http://haidut.me/?p=1627 Wed, 15 Sep 2021 15:34:06 +0000 00:01:51 false https://haidut.me/?p=1625 http://haidut.me/?p=1625 Mon, 13 Sep 2021 15:21:59 +0000 00:00:38 false https://haidut.me/?p=1622 http://haidut.me/?p=1622 Fri, 10 Sep 2021 14:20:44 +0000 00:02:33 false https://haidut.me/?p=1619 http://haidut.me/?p=1619 Thu, 09 Sep 2021 15:50:23 +0000 00:03:23 false https://haidut.me/?p=1617 http://haidut.me/?p=1617 Mon, 06 Sep 2021 16:56:50 +0000 00:01:43 false https://haidut.me/?p=1615 http://haidut.me/?p=1615 Sun, 29 Aug 2021 19:32:50 +0000 00:05:08 false https://haidut.me/?p=1612 http://haidut.me/?p=1612 Fri, 27 Aug 2021 16:55:21 +0000 00:01:19 false https://haidut.me/?p=1609 http://haidut.me/?p=1609 Fri, 27 Aug 2021 16:43:09 +0000 00:03:23 false https://haidut.me/?p=1606 http://haidut.me/?p=1606 Fri, 27 Aug 2021 16:04:54 +0000 00:04:09 false https://haidut.me/?p=1602 http://haidut.me/?p=1602 Fri, 27 Aug 2021 15:32:38 +0000 00:01:59 false https://haidut.me/?p=1600 http://haidut.me/?p=1600 Fri, 27 Aug 2021 15:05:46 +0000 00:01:44 false https://haidut.me/?p=1596 http://haidut.me/?p=1596 Fri, 13 Aug 2021 18:19:26 +0000 00:02:26 false https://haidut.me/?p=1592 http://haidut.me/?p=1592 Fri, 13 Aug 2021 17:41:29 +0000 00:00:31 false https://haidut.me/?p=1590 http://haidut.me/?p=1590 Fri, 13 Aug 2021 17:06:13 +0000 50) in Caenorhabditis elegans even after the original stress signal has been gone. The transgenerational induction of UPRmt was caused by the elevated mtDNA inherited maternally, which disturbed the balance between mitochondrial oxidative phosphorylation subunits encoded by the mtDNA and the nuclear DNA to induce mitochondrial proteostasis stress. Wnt signaling is required for the propagation of elevated mtDNA levels across generations via transgenerational regulation of the mtDNA polymerase polg-1.”]]> 00:01:04 false https://haidut.me/?p=1588 http://haidut.me/?p=1588 Fri, 13 Aug 2021 16:51:15 +0000 00:02:54 false https://haidut.me/?p=1586 http://haidut.me/?p=1586 Wed, 28 Jul 2021 15:15:31 +0000 00:02:16 false https://haidut.me/?p=1584 http://haidut.me/?p=1584 Mon, 26 Jul 2021 15:50:09 +0000 00:00:50 false https://haidut.me/?p=1582 http://haidut.me/?p=1582 Mon, 26 Jul 2021 15:33:08 +0000 00:00:58 false https://haidut.me/?p=1579 http://haidut.me/?p=1579 Mon, 26 Jul 2021 15:16:28 +0000 00:01:05 false https://haidut.me/?p=1574 http://haidut.me/?p=1574 Mon, 19 Jul 2021 18:27:02 +0000 00:01:04 false https://haidut.me/?p=1572 http://haidut.me/?p=1572 Mon, 19 Jul 2021 18:15:18 +0000 00:01:25 false https://haidut.me/?p=1570 http://haidut.me/?p=1570 Mon, 19 Jul 2021 17:52:22 +0000 00:01:19 false https://haidut.me/?p=1567 http://haidut.me/?p=1567 Mon, 19 Jul 2021 17:26:42 +0000 00:00:48 false https://haidut.me/?p=1563 http://haidut.me/?p=1563 Mon, 19 Jul 2021 16:01:19 +0000 00:01:29 false https://haidut.me/?p=1560 http://haidut.me/?p=1560 Mon, 19 Jul 2021 15:42:49 +0000 00:00:33 false https://haidut.me/?p=1557 http://haidut.me/?p=1557 Mon, 19 Jul 2021 15:04:34 +0000 00:03:53 false https://haidut.me/?p=1555 http://haidut.me/?p=1555 Mon, 19 Jul 2021 14:00:58 +0000 00:01:32 false https://haidut.me/?p=1551 http://haidut.me/?p=1551 Fri, 18 Jun 2021 00:46:55 +0000 00:04:38 false https://haidut.me/?p=1547 http://haidut.me/?p=1547 Wed, 09 Jun 2021 18:32:18 +0000 00:01:44 false https://haidut.me/?p=1545 http://haidut.me/?p=1545 Wed, 09 Jun 2021 18:01:40 +0000 00:03:25 false https://haidut.me/?p=1543 http://haidut.me/?p=1543 Wed, 09 Jun 2021 15:40:05 +0000 00:01:07 false https://haidut.me/?p=1541 http://haidut.me/?p=1541 Wed, 09 Jun 2021 15:20:41 +0000 00:02:08 false https://haidut.me/?p=1539 http://haidut.me/?p=1539 Wed, 09 Jun 2021 15:03:19 +0000 00:02:31 false https://haidut.me/?p=1537 http://haidut.me/?p=1537 Mon, 31 May 2021 00:39:59 +0000 00:03:38 false https://haidut.me/?p=1535 http://haidut.me/?p=1535 Sun, 30 May 2021 21:21:32 +0000 00:01:33 false https://haidut.me/?p=1533 http://haidut.me/?p=1533 Sun, 30 May 2021 20:54:24 +0000 00:00:46 false https://haidut.me/?p=1531 http://haidut.me/?p=1531 Sun, 30 May 2021 20:45:38 +0000 00:01:19 false https://haidut.me/?p=1527 http://haidut.me/?p=1527 Fri, 28 May 2021 13:45:26 +0000 00:01:45 false https://haidut.me/?p=1525 http://haidut.me/?p=1525 Fri, 28 May 2021 13:26:52 +0000 00:01:22 false https://haidut.me/?p=1523 http://haidut.me/?p=1523 Fri, 28 May 2021 12:40:10 +0000 00:01:11 false https://haidut.me/?p=1521 http://haidut.me/?p=1521 Wed, 26 May 2021 15:34:31 +0000 00:02:53 false https://haidut.me/?p=1516 http://haidut.me/?p=1516 Mon, 10 May 2021 18:10:48 +0000 00:01:56 false https://haidut.me/?p=1514 http://haidut.me/?p=1514 Mon, 10 May 2021 17:45:12 +0000 00:01:55 false https://haidut.me/?p=1512 http://haidut.me/?p=1512 Mon, 10 May 2021 17:20:34 +0000 00:01:45 false https://haidut.me/?p=1510 http://haidut.me/?p=1510 Mon, 10 May 2021 17:00:32 +0000 00:00:46 false https://haidut.me/?p=1507 http://haidut.me/?p=1507 Mon, 10 May 2021 16:49:22 +0000 00:02:17 false https://haidut.me/?p=1505 http://haidut.me/?p=1505 Wed, 28 Apr 2021 20:08:47 +0000 00:01:58 false https://haidut.me/?p=1503 http://haidut.me/?p=1503 Wed, 28 Apr 2021 17:26:17 +0000 00:01:36 false https://haidut.me/?p=1501 http://haidut.me/?p=1501 Wed, 28 Apr 2021 16:07:28 +0000 00:05:17 false https://haidut.me/?p=1499 http://haidut.me/?p=1499 Tue, 27 Apr 2021 19:58:00 +0000 00:01:17 false https://haidut.me/?p=1497 http://haidut.me/?p=1497 Tue, 27 Apr 2021 19:43:17 +0000 12 nmol/L) to be significant predictors of AMS scores. A 0.1 nmol/l serum DHT increase within the eugonadal range was associated with a 4.67% decrease in odds of having worse symptoms (p = 0.011). In men with biochemical hypogonadism (Total T < 12 nmol/L), total and free T rather than DHT were associated with AMS results. This association was not found for IIEF-EF scores. Indirect effects of age and BMI were seen for relations with hormone concentrations but not questionnaire scores. Conclusion: DHT can be associated with symptoms of hypogonadism in biochemically eugonadal men. Serum DHT measurement might be helpful once the diagnosis of hypogonadism has been ruled out but should not be routinely included in the primary diagnostic process.”]]> 00:00:47 false https://haidut.me/?p=1495 http://haidut.me/?p=1495 Tue, 27 Apr 2021 19:31:01 +0000 00:02:21 false https://haidut.me/?p=1491 http://haidut.me/?p=1491 Tue, 27 Apr 2021 18:48:14 +0000 00:01:14 false https://haidut.me/?p=1489 http://haidut.me/?p=1489 Tue, 27 Apr 2021 18:32:12 +0000 00:01:42 false https://haidut.me/?p=1487 http://haidut.me/?p=1487 Tue, 27 Apr 2021 18:15:30 +0000 00:01:42 false https://haidut.me/?p=1485 http://haidut.me/?p=1485 Tue, 27 Apr 2021 17:51:59 +0000 00:02:08 false https://haidut.me/?p=1483 http://haidut.me/?p=1483 Tue, 27 Apr 2021 17:23:17 +0000 00:00:59 false https://haidut.me/?p=1481 http://haidut.me/?p=1481 Tue, 27 Apr 2021 17:13:11 +0000 00:02:10 false https://haidut.me/?p=1477 http://haidut.me/?p=1477 Tue, 27 Apr 2021 16:51:59 +0000 00:01:32 false https://haidut.me/?p=1475 http://haidut.me/?p=1475 Tue, 27 Apr 2021 16:36:33 +0000 00:01:33 false https://haidut.me/?p=1466 http://haidut.me/?p=1466 Thu, 18 Mar 2021 15:04:17 +0000 00:02:12 false https://haidut.me/?p=1462 http://haidut.me/?p=1462 Wed, 17 Mar 2021 18:04:36 +0000 00:01:01 false https://haidut.me/?p=1456 http://haidut.me/?p=1456 Wed, 17 Mar 2021 17:33:28 +0000 00:01:21 false https://haidut.me/?p=1454 http://haidut.me/?p=1454 Wed, 17 Mar 2021 14:58:17 +0000 00:02:19 false https://haidut.me/?p=1452 http://haidut.me/?p=1452 Wed, 17 Mar 2021 14:33:29 +0000 00:02:53 false https://haidut.me/?p=1449 http://haidut.me/?p=1449 Tue, 16 Mar 2021 20:01:02 +0000 00:01:57 false https://haidut.me/?p=1447 http://haidut.me/?p=1447 Tue, 16 Mar 2021 19:24:02 +0000 00:02:13 false https://haidut.me/?p=1445 http://haidut.me/?p=1445 Tue, 16 Mar 2021 19:02:01 +0000 00:00:56 false https://haidut.me/?p=1443 http://haidut.me/?p=1443 Tue, 16 Mar 2021 18:36:59 +0000 00:02:02 false https://haidut.me/?p=1441 http://haidut.me/?p=1441 Tue, 16 Mar 2021 18:02:46 +0000 00:01:50 false https://haidut.me/?p=1439 http://haidut.me/?p=1439 Thu, 04 Mar 2021 05:03:42 +0000 00:01:34 false https://haidut.me/?p=1437 http://haidut.me/?p=1437 Thu, 04 Mar 2021 04:39:29 +0000 00:03:35 false https://haidut.me/?p=1435 http://haidut.me/?p=1435 Thu, 04 Mar 2021 04:18:17 +0000 00:01:38 false https://haidut.me/?p=1433 http://haidut.me/?p=1433 Thu, 04 Mar 2021 03:59:06 +0000 00:02:34 false https://haidut.me/?p=1431 http://haidut.me/?p=1431 Thu, 04 Mar 2021 03:07:10 +0000 00:03:29 false https://haidut.me/?p=1427 http://haidut.me/?p=1427 Thu, 04 Mar 2021 02:36:15 +0000 00:04:26 false https://haidut.me/?p=1423 http://haidut.me/?p=1423 Wed, 17 Feb 2021 20:35:00 +0000 00:01:42 false https://haidut.me/?p=1421 http://haidut.me/?p=1421 Wed, 17 Feb 2021 19:21:07 +0000 00:03:33 false https://haidut.me/?p=1419 http://haidut.me/?p=1419 Wed, 17 Feb 2021 18:48:13 +0000 00:00:51 false https://haidut.me/?p=1414 http://haidut.me/?p=1414 Wed, 17 Feb 2021 18:03:41 +0000 0.05; Fig. 5). The addition of 10–5 M progesterone, however, did result in a statistically significant increase in the percentage of apoptosis of LNCaP cells when compared with samples incubated with progesterone alone and samples incubated with indomethacin plus 10–9 M DHT (P<0.05; Fig. 5). The increased apoptosis seen in the presence of progesterone plus indomethacin was not significantly different from that seen in the presence of an equivalent amount of DHT plus indomethacin (10–5 M; P>0.05).” “…We found that in addition to DHT, progesterone, but not hydrocortisone, promoted indomethacin-induced apoptosis. The finding that progesterone behaves in a manner similar to DHT is perhaps not unexpected in that LNCaP cells possess a mutated androgen receptor with a high affinity for progesterone [39]. Furthermore, the presence of progesterone, like DHT, both stimulates and inhibits the growth of LNCaP cells [32, 33]. Our observation that androgen-insensitive cells (i.e. PC-3 cells) did not respond to indomethacin-induced apoptosis in the presence of high concentrations of DHT, further indicates that the androgen receptor is needed to elicit the synergistic effect between DHT and NSAIDs.” “…Prostate cancer is one of the leading causes of cancer-related deaths in men in the United States [16]. Although androgen ablation produces significant palliation of symptoms in patients with advanced prostate cancer, the proportion of tumors that regress is actually relatively small [4]. More important, however, is the fact that this treatment regimen is doomed to failure in the long term because it promotes hormone-refractory disease, which is ultimately lethal to the patient. In a recent article, Prehn [27] has argued that declining rather than high levels of androgens contribute to human prostate carcinogenesis and that androgen supplementation may lower the incidence of the disease. In fact, high levels of androgen appear to be inhibitory to prostatic cells (due to a mechanism mediated by the androgen receptor), and excess androgen can inhibit prostate cancers under experimental conditions [15, 25, 34, 37, 41, 42]. Significant regression of prostate cancer in response to exogenous androgen has also been seen in a substantial proportion of the few patients in whom this treatment has been tried [2, 21, 28, 36]. With respect to future treatment regimens, our observations indicate that prolonged exposure to high concentrations of DHT may predispose prostate cancer cells to effective NSAID treatment.”]]> 00:03:46 false https://haidut.me/?p=1412 http://haidut.me/?p=1412 Wed, 17 Feb 2021 04:16:38 +0000 00:02:53 false https://haidut.me/?p=1409 http://haidut.me/?p=1409 Tue, 16 Feb 2021 20:58:07 +0000 00:03:11 false https://haidut.me/?p=1405 http://haidut.me/?p=1405 Tue, 16 Feb 2021 20:22:37 +0000 00:02:28 false https://haidut.me/?p=1403 http://haidut.me/?p=1403 Tue, 16 Feb 2021 19:49:00 +0000 00:02:39 false https://haidut.me/?p=1401 http://haidut.me/?p=1401 Tue, 16 Feb 2021 17:36:06 +0000 disease connection is due to “genetic vulnerability” in those children rather than suboptimal environment during childhood. Well, the study below contradicts that genetic narrative once again. It demonstrates that childhood stress (in this case, poverty) leads to significantly blunted increases in testosterone (T) levels during puberty and, as such, lower T levels in adulthood. Interestingly enough, about half of the participants in the study were females, so this is yet another study demonstrating the falsehood of blindly assigning the labels “male” or “female” to any steroid without considering the context and stage or an organism’s development. Apparently, T is also absolutely crucial for female development, and especially for brain volume/maturation (as the study below demonstrates). Namely, the deficiency of T due to stress resulted in much smaller volume of the hippocampus, and as such greatly reduced ability to regulate emotions, in both males and females. While the study did not find a link between childhood stress and lower DHEA levels in adulthood, other studies have found such a link. The reason I am bringing this up is that T and DHEA are two of the major endogenous cortisol antagonists, and lower levels of one/both of those steroids results in amplification of cortisol’s effects on all tissues/organs. It is already known from multiple animal studies that cortisol shrinks the brain, and especially the portions responsible for emotional regulation and higher cognitive function. Cortisol is as catabolic for the brain as it is for muscle/thymus. Thus, the findings of the study should not be at all surprising, considering that childhood stress leads to chronic hyperactivity of the HPA axis. If that is the case, possible remedies include all known anti-cortisol interventions such as thyroid, pregnenolone, progesterone, DHEA, T, DHT, emodin, salt, niacinamide, etc. The brain is quite capable of regeneration as long as the right nutrition is provided and excess cortisol is reigned in. 2 links here “…Early poverty has been established as a risk factor for developmental issues and has been tied to psychological impairment in childhood and adulthood. Intervention strategies to address these consequences early on are needed. Deanna M. Barch, link here, the Gregory B. Couch Professor of Psychiatry at Washington University, and her colleagues note that in order to design effective interventions, researchers first need to understand the mechanisms behind the link between early poverty and impaired mental health. The researchers proposed that the hippocampus, a major brain structure situated in the temporal lobe, might be implicated in this pathway. There is evidence that early adversity is linked to dysfunction in the hippocampus, with some studies pointing to decreased hippocampal volume and altered connectivity in the hippocampus. In turn, hippocampal dysfunction has been linked to emotional dysregulation problems and increased risk of depression.” “…The researchers proposed a pathway whereby stress affects the testosterone and dehydroepiandosterone (DHEA) hormones through modulation of the hypothalamic–pituitary–gonadal (HPG) axis. This dysregulation of hormones may then disrupt hippocampal development, leading to impaired emotion regulation and greater risk of depression.” “…Through a series of analyses, Barch and her team found that early poverty did predict shallower increases in testosterone throughout adolescence, even when accounting for early depression. Early poverty also predicted higher depression scores and worse emotion regulation scores at the last assessment, when the youth were an average of 15 years old. Early poverty did not appear to affect DHEA. Furthermore, there was evidence that testosterone slopes and mental health outcomes were linked. Steeper increases in testosterone over the years were associated with larger increases in hippocampal growth, as well as decreased emotion dysregulation and lower depression at the last assessment. Finally, it appeared that larger hippocampal volume growth across time was also tied to better emotion regulation.”]]> 00:02:37 false https://haidut.me/?p=1399 http://haidut.me/?p=1399 Tue, 09 Feb 2021 20:19:05 +0000 00:01:30 false https://haidut.me/?p=1397 http://haidut.me/?p=1397 Tue, 09 Feb 2021 20:00:52 +0000 00:02:54 false https://haidut.me/?p=1395 http://haidut.me/?p=1395 Tue, 09 Feb 2021 00:36:01 +0000 00:01:51 false https://haidut.me/?p=1393 http://haidut.me/?p=1393 Mon, 08 Feb 2021 23:58:05 +0000 00:01:33 false https://haidut.me/?p=1388 http://haidut.me/?p=1388 Mon, 08 Feb 2021 21:23:24 +0000 00:03:01 false https://haidut.me/?p=1385 http://haidut.me/?p=1385 Mon, 08 Feb 2021 20:41:16 +0000 00:02:48 false https://haidut.me/?p=1382 http://haidut.me/?p=1382 Mon, 01 Feb 2021 00:36:42 +0000 00:02:09 false https://haidut.me/?p=1380 http://haidut.me/?p=1380 Sun, 31 Jan 2021 23:58:21 +0000 00:07:11 false https://haidut.me/?p=1378 http://haidut.me/?p=1378 Thu, 07 Jan 2021 19:23:08 +0000 00:01:02 false https://haidut.me/?p=1376 http://haidut.me/?p=1376 Thu, 07 Jan 2021 19:09:41 +0000 00:02:26 false https://haidut.me/?p=1374 http://haidut.me/?p=1374 Thu, 07 Jan 2021 18:09:18 +0000 00:00:45 false https://haidut.me/?p=1372 http://haidut.me/?p=1372 Thu, 07 Jan 2021 17:53:40 +0000 00:01:49 false https://haidut.me/?p=1370 http://haidut.me/?p=1370 Thu, 07 Jan 2021 17:30:30 +0000 00:02:18 false https://haidut.me/?p=1363 http://haidut.me/?p=1363 Wed, 16 Dec 2020 21:09:08 +0000 00:02:42 false https://haidut.me/?p=1361 http://haidut.me/?p=1361 Wed, 16 Dec 2020 20:37:36 +0000 00:04:11 false https://haidut.me/?p=1359 http://haidut.me/?p=1359 Wed, 16 Dec 2020 19:42:43 +0000 00:01:50 false https://haidut.me/?p=1357 http://haidut.me/?p=1357 Fri, 11 Dec 2020 18:40:11 +0000 00:02:46 false https://haidut.me/?p=1355 http://haidut.me/?p=1355 Fri, 11 Dec 2020 18:08:57 +0000 00:01:23 false https://haidut.me/?p=1353 http://haidut.me/?p=1353 Fri, 11 Dec 2020 17:46:16 +0000 00:01:20 false https://haidut.me/?p=1349 http://haidut.me/?p=1349 Tue, 08 Dec 2020 18:11:43 +0000 00:00:55 false https://haidut.me/?p=1346 http://haidut.me/?p=1346 Mon, 07 Dec 2020 17:34:29 +0000 00:03:13 false https://haidut.me/?p=1344 http://haidut.me/?p=1344 Mon, 07 Dec 2020 16:16:15 +0000 00:02:03 false https://haidut.me/?p=1337 http://haidut.me/?p=1337 Wed, 02 Dec 2020 18:36:12 +0000 00:02:04 false https://haidut.me/?p=1335 http://haidut.me/?p=1335 Wed, 02 Dec 2020 18:13:00 +0000 00:02:06 false https://haidut.me/?p=1333 http://haidut.me/?p=1333 Wed, 02 Dec 2020 17:54:44 +0000 00:02:26 false https://haidut.me/?p=1330 http://haidut.me/?p=1330 Wed, 02 Dec 2020 17:37:11 +0000 00:10:06 false https://haidut.me/?p=1325 http://haidut.me/?p=1325 Tue, 24 Nov 2020 15:50:50 +0000 00:03:38 false https://haidut.me/?p=1323 http://haidut.me/?p=1323 Fri, 20 Nov 2020 20:54:31 +0000 00:01:38 false https://haidut.me/?p=1320 http://haidut.me/?p=1320 Fri, 20 Nov 2020 19:39:31 +0000 00:00:30 false https://haidut.me/?p=1317 http://haidut.me/?p=1317 Fri, 20 Nov 2020 19:02:10 +0000 00:02:12 false https://haidut.me/?p=1314 http://haidut.me/?p=1314 Tue, 17 Nov 2020 16:20:29 +0000 00:02:24 false https://haidut.me/?p=1311 http://haidut.me/?p=1311 Sun, 15 Nov 2020 21:03:19 +0000 00:02:22 false https://haidut.me/?p=1306 http://haidut.me/?p=1306 Fri, 06 Nov 2020 20:15:59 +0000 00:00:41 false https://haidut.me/?p=1304 http://haidut.me/?p=1304 Fri, 06 Nov 2020 19:49:59 +0000 350 million people, causing a high personal and socioeconomic burden (World Health Organization, 2017). It is well reported that chronic stress and hypothalamic-pituitary-adrenal (HPA) axis dysfunction are risk factors for MDD (Goodyer et al., 2000; Nowacki et al., 2020). Chronic stress can induce increased levels of glucocorticoids, namely cortisol in humans and corticosterone in rodents, which may damage the hippocampus, a region that presents a high density of glucocorticoids receptor (GR) crucial for HPA axis autoregulation and mood modulation (Anacker et al., 2011; Lee et al., 2002).” “…In keeping with these premises, exogenous corticosterone (CORT) administration in rodents has been proposed as a pharmacological stress model of depression that mimics the behavioral and neurochemical alterations associated with HPA dysfunction in the depressive state (Pazini et al., 2016; Rosa et al., 2014; Zhao et al., 2008). Despite the numerous studies reporting that chronic stress underlies the genesis of MDD, the mechanisms by which glucocorticoids contribute to the depressive symptoms have not been entirely established. Compelling evidence indicates that glucocorticoids may induce a peripheral and central pro-inflammatory state that involves the stimulation of the nod-like receptor pyrin domain containing 3 (NLRP3), an intracellular multiprotein complex responsible for the inflammatory response (Busillo et al., 2011; Kaufmann et al., 2017). Importantly, NLRP3-driven pro-inflammatory response culminates in neuronal damage and death remarkably in brain regions involved with mood modulation, and these events are thought to underlie depressive symptoms (Miller et al., 2009).” “…In the present study, we showed that a low dose of cholecalciferol abrogates the depressive- and anhedonic-like behavior induced by chronic corticosterone administration, confirming a previous study from our group (Camargo et al., 2018). We extend these findings providing evidence that these behavioral effects were accompanied by the reestablishment of GR immunocontent impaired by corticosterone. Additionally, the ability of cholecalciferol in reducing NLRP3 inflammasome-related proteins ASC, TXNIP, and caspase-1 in the hippocampus of mice was also demonstrated.” “… In the present study, we reinforced the notion that repeated administration of cholecalciferol (2.5 μg/kg, p.o.) for 7 days is effective to reduce the immobility time, in a way similar to fluoxetine, in vehicle-treated mice submitted to the TST (Camargo et al., 2018; Souza et al., 2020). We also showed the cholecalciferol’s ability to prevent corticosterone-induced depressivelike behavior evaluated in the TST, when administered in the last 7 days of corticosterone protocol. This result agrees with previous reports of our research group carried out in male Swiss mice (Camargo et al., 2018) and female Swiss mice (Souza et al., 2020). Of note, previous studies showed that administration of cholecalciferol (5 mg/kg, s.c.) or α-calcidiol (1 μg/kg, p.o.) caused an antidepressant-like effect in the forced swim test in rodents (Fedotova et al., 2016; Kawaura et al., 2017), in agreement with our results.” “…Collectively, our results show that repeated administration of cholecalciferol has an antidepressant-like effect, confirming previous findings (Camargo et al., 2018; Fedotova et al., 2016; Kawaura et al., 2017; Souza et al., 2020), an effect associated with the reestablishment of hippocampal GR immunocontent impaired by chronic corticosterone administration. Although we did not ascertain the causal relationship between GR and behavioral outcomes, further experiments could be carried out in future studies to shed light on this issue.”]]> 00:02:58 false https://haidut.me/?p=1297 http://haidut.me/?p=1297 Thu, 05 Nov 2020 20:28:07 +0000 00:05:46 false https://haidut.me/?p=1292 http://haidut.me/?p=1292 Thu, 05 Nov 2020 18:34:25 +0000 00:04:20 false https://haidut.me/?p=1287 http://haidut.me/?p=1287 Tue, 03 Nov 2020 19:58:08 +0000 00:05:39 false https://haidut.me/?p=1285 http://haidut.me/?p=1285 Tue, 03 Nov 2020 19:05:12 +0000 00:02:48 false https://haidut.me/?p=1281 http://haidut.me/?p=1281 Mon, 02 Nov 2020 18:23:54 +0000 00:01:52 false https://haidut.me/?p=1279 http://haidut.me/?p=1279 Mon, 02 Nov 2020 18:03:59 +0000 00:01:44 false https://haidut.me/?p=1277 http://haidut.me/?p=1277 Tue, 27 Oct 2020 14:44:33 +0000 00:05:35 false https://haidut.me/?p=1274 http://haidut.me/?p=1274 Mon, 26 Oct 2020 18:40:58 +0000 00:01:41 false https://haidut.me/?p=1271 http://haidut.me/?p=1271 Mon, 26 Oct 2020 18:18:03 +0000 00:01:06 false https://haidut.me/?p=1268 http://haidut.me/?p=1268 Mon, 26 Oct 2020 18:04:35 +0000 00:00:48 false https://haidut.me/?p=1265 http://haidut.me/?p=1265 Mon, 26 Oct 2020 17:41:35 +0000 00:02:47 false https://haidut.me/?p=1262 http://haidut.me/?p=1262 Thu, 22 Oct 2020 13:57:19 +0000 00:01:57 false https://haidut.me/?p=1259 http://haidut.me/?p=1259 Thu, 15 Oct 2020 19:32:15 +0000 00:02:23 false https://haidut.me/?p=1256 http://haidut.me/?p=1256 Thu, 15 Oct 2020 16:37:06 +0000 00:01:38 false https://haidut.me/?p=1252 http://haidut.me/?p=1252 Tue, 06 Oct 2020 19:33:11 +0000 00:01:15 false https://haidut.me/?p=1250 http://haidut.me/?p=1250 Sun, 04 Oct 2020 23:33:44 +0000 00:01:13 false https://haidut.me/?p=1245 http://haidut.me/?p=1245 Thu, 01 Oct 2020 17:44:53 +0000 00:03:11 false https://haidut.me/?p=1243 http://haidut.me/?p=1243 Thu, 01 Oct 2020 16:22:42 +0000 00:04:47 false https://haidut.me/?p=1240 http://haidut.me/?p=1240 Wed, 30 Sep 2020 20:09:26 +0000 00:02:01 false https://haidut.me/?p=1238 http://haidut.me/?p=1238 Wed, 30 Sep 2020 19:35:20 +0000 00:02:05 false https://haidut.me/?p=1236 http://haidut.me/?p=1236 Thu, 24 Sep 2020 16:00:43 +0000 00:01:24 false https://haidut.me/?p=1234 http://haidut.me/?p=1234 Thu, 24 Sep 2020 15:39:33 +0000 00:02:57 false https://haidut.me/?p=1232 http://haidut.me/?p=1232 Tue, 22 Sep 2020 15:40:11 +0000 00:03:25 false https://haidut.me/?p=1230 http://haidut.me/?p=1230 Tue, 22 Sep 2020 14:43:34 +0000 00:01:50 false https://haidut.me/?p=1228 http://haidut.me/?p=1228 Tue, 22 Sep 2020 14:10:29 +0000 00:02:00 false https://haidut.me/?p=1226 http://haidut.me/?p=1226 Fri, 18 Sep 2020 16:17:40 +0000 00:05:19 false https://haidut.me/?p=1222 http://haidut.me/?p=1222 Fri, 18 Sep 2020 14:13:19 +0000 00:02:02 false https://haidut.me/?p=1220 http://haidut.me/?p=1220 Fri, 18 Sep 2020 13:44:49 +0000 00:02:11 false https://haidut.me/?p=1218 http://haidut.me/?p=1218 Fri, 18 Sep 2020 13:19:13 +0000 00:00:46 false https://haidut.me/?p=1208 http://haidut.me/?p=1208 Fri, 11 Sep 2020 17:19:38 +0000 00:07:12 false https://haidut.me/?p=1205 http://haidut.me/?p=1205 Thu, 10 Sep 2020 16:53:12 +0000 00:02:14 false https://haidut.me/?p=1202 http://haidut.me/?p=1202 Thu, 10 Sep 2020 16:26:23 +0000 00:04:27 false https://haidut.me/?p=1200 http://haidut.me/?p=1200 Thu, 10 Sep 2020 15:59:12 +0000 00:00:47 false https://haidut.me/?p=1195 http://haidut.me/?p=1195 Wed, 09 Sep 2020 20:30:02 +0000 00:04:08 false https://haidut.me/?p=1193 http://haidut.me/?p=1193 Wed, 09 Sep 2020 19:44:52 +0000 00:01:56 false https://haidut.me/?p=1191 http://haidut.me/?p=1191 Wed, 09 Sep 2020 18:06:09 +0000 00:01:44 false https://haidut.me/?p=1189 http://haidut.me/?p=1189 Wed, 09 Sep 2020 16:52:03 +0000 00:03:32 false https://haidut.me/?p=1187 http://haidut.me/?p=1187 Wed, 09 Sep 2020 16:03:29 +0000 00:02:13 false https://haidut.me/?p=1183 http://haidut.me/?p=1183 Fri, 14 Aug 2020 17:36:21 +0000 00:02:05 false https://haidut.me/?p=1181 http://haidut.me/?p=1181 Fri, 14 Aug 2020 17:06:41 +0000 00:00:28 false https://haidut.me/?p=1179 http://haidut.me/?p=1179 Fri, 14 Aug 2020 16:53:03 +0000 00:02:21 false https://haidut.me/?p=1177 http://haidut.me/?p=1177 Fri, 14 Aug 2020 16:18:08 +0000 00:01:19 false https://haidut.me/?p=1175 http://haidut.me/?p=1175 Thu, 13 Aug 2020 19:46:29 +0000 00:01:39 false https://haidut.me/?p=1170 http://haidut.me/?p=1170 Thu, 13 Aug 2020 17:55:11 +0000 00:01:39 false https://haidut.me/?p=1165 http://haidut.me/?p=1165 Sun, 26 Jul 2020 23:42:23 +0000 00:03:28 false https://haidut.me/?p=1161 http://haidut.me/?p=1161 Thu, 23 Jul 2020 19:38:07 +0000 00:01:36 false https://haidut.me/?p=1159 http://haidut.me/?p=1159 Thu, 23 Jul 2020 19:00:55 +0000 00:01:57 false https://haidut.me/?p=1157 http://haidut.me/?p=1157 Thu, 23 Jul 2020 18:41:51 +0000 00:03:08 false 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https://haidut.me/?p=1100 http://haidut.me/?p=1100 Sat, 06 Jun 2020 15:15:53 +0000 00:01:02 false https://haidut.me/?p=1098 http://haidut.me/?p=1098 Sat, 06 Jun 2020 14:54:13 +0000 00:03:41 false https://haidut.me/?p=1096 http://haidut.me/?p=1096 Fri, 05 Jun 2020 19:44:26 +0000 00:02:24 false https://haidut.me/?p=1092 http://haidut.me/?p=1092 Fri, 05 Jun 2020 17:56:42 +0000 00:02:15 false https://haidut.me/?p=1090 http://haidut.me/?p=1090 Fri, 05 Jun 2020 17:22:04 +0000 00:01:39 false https://haidut.me/?p=1086 http://haidut.me/?p=1086 Fri, 05 Jun 2020 17:02:50 +0000 00:03:42 false https://haidut.me/?p=1084 http://haidut.me/?p=1084 Fri, 05 Jun 2020 15:53:19 +0000 00:01:43 false https://haidut.me/?p=1082 http://haidut.me/?p=1082 Fri, 05 Jun 2020 15:33:17 +0000 00:04:12 false https://haidut.me/?p=1073 http://haidut.me/?p=1073 Thu, 14 May 2020 18:12:33 +0000 00:03:41 false https://haidut.me/?p=1071 http://haidut.me/?p=1071 Thu, 14 May 2020 17:49:05 +0000 00:02:49 false https://haidut.me/?p=1069 http://haidut.me/?p=1069 Thu, 14 May 2020 16:14:03 +0000 00:02:23 false https://haidut.me/?p=1065 http://haidut.me/?p=1065 Wed, 13 May 2020 19:47:42 +0000 00:02:15 false https://haidut.me/?p=1063 http://haidut.me/?p=1063 Wed, 13 May 2020 19:16:18 +0000 00:01:21 false https://haidut.me/?p=1061 http://haidut.me/?p=1061 Wed, 13 May 2020 18:14:09 +0000 00:06:54 false https://haidut.me/?p=1057 http://haidut.me/?p=1057 Mon, 04 May 2020 17:45:47 +0000 00:02:44 false https://haidut.me/?p=1055 http://haidut.me/?p=1055 Sun, 03 May 2020 22:49:52 +0000 00:01:14 false https://haidut.me/?p=1053 http://haidut.me/?p=1053 Sun, 03 May 2020 22:29:35 +0000 00:01:56 false https://haidut.me/?p=1051 http://haidut.me/?p=1051 Sun, 03 May 2020 21:08:25 +0000 00:03:36 false https://haidut.me/?p=1049 http://haidut.me/?p=1049 Sun, 03 May 2020 15:50:07 +0000 00:03:06 false https://haidut.me/?p=1045 http://haidut.me/?p=1045 Mon, 27 Apr 2020 18:46:54 +0000 00:02:36 false https://haidut.me/?p=1038 http://haidut.me/?p=1038 Wed, 22 Apr 2020 18:38:12 +0000 00:03:25 false https://haidut.me/?p=1036 http://haidut.me/?p=1036 Wed, 22 Apr 2020 17:42:02 +0000 00:01:52 false https://haidut.me/?p=1031 http://haidut.me/?p=1031 Wed, 22 Apr 2020 03:27:06 +0000 00:01:14 false https://haidut.me/?p=1029 http://haidut.me/?p=1029 Wed, 22 Apr 2020 03:13:07 +0000 00:01:47 false https://haidut.me/?p=1027 http://haidut.me/?p=1027 Wed, 22 Apr 2020 02:56:07 +0000 00:01:02 false https://haidut.me/?p=1023 http://haidut.me/?p=1023 Wed, 22 Apr 2020 02:34:40 +0000 00:01:48 false https://haidut.me/?p=1021 http://haidut.me/?p=1021 Tue, 21 Apr 2020 20:16:22 +0000 00:00:38 false https://haidut.me/?p=1019 http://haidut.me/?p=1019 Tue, 21 Apr 2020 20:00:09 +0000 00:02:08 false https://haidut.me/?p=1017 http://haidut.me/?p=1017 Tue, 21 Apr 2020 19:35:10 +0000 00:02:04 false https://haidut.me/?p=1014 http://haidut.me/?p=1014 Tue, 21 Apr 2020 19:10:49 +0000 00:02:22 false https://haidut.me/?p=1012 http://haidut.me/?p=1012 Tue, 21 Apr 2020 18:57:17 +0000 00:02:50 false https://haidut.me/?p=1010 http://haidut.me/?p=1010 Tue, 21 Apr 2020 18:28:27 +0000 00:02:31 false https://haidut.me/?p=1003 http://haidut.me/?p=1003 Wed, 15 Apr 2020 18:10:10 +0000 00:01:14 false https://haidut.me/?p=1001 http://haidut.me/?p=1001 Wed, 15 Apr 2020 17:50:07 +0000 00:01:14 false https://haidut.me/?p=999 http://haidut.me/?p=999 Wed, 15 Apr 2020 17:21:31 +0000 00:02:32 false https://haidut.me/?p=995 http://haidut.me/?p=995 Wed, 15 Apr 2020 16:41:16 +0000 00:00:41 false https://haidut.me/?p=991 http://haidut.me/?p=991 Tue, 14 Apr 2020 22:01:19 +0000 00:00:48 false https://haidut.me/?p=989 http://haidut.me/?p=989 Tue, 14 Apr 2020 21:45:55 +0000 00:01:26 false https://haidut.me/?p=987 http://haidut.me/?p=987 Tue, 14 Apr 2020 21:32:40 +0000 00:01:02 false https://haidut.me/?p=984 http://haidut.me/?p=984 Tue, 14 Apr 2020 20:24:06 +0000 00:00:58 false https://haidut.me/?p=982 http://haidut.me/?p=982 Tue, 14 Apr 2020 20:04:55 +0000 00:00:49 false https://haidut.me/?p=980 http://haidut.me/?p=980 Tue, 14 Apr 2020 19:48:04 +0000 00:01:26 false https://haidut.me/?p=978 http://haidut.me/?p=978 Tue, 14 Apr 2020 19:32:42 +0000 00:01:05 false https://haidut.me/?p=976 http://haidut.me/?p=976 Tue, 14 Apr 2020 19:19:33 +0000 00:01:16 false https://haidut.me/?p=974 http://haidut.me/?p=974 Mon, 13 Apr 2020 21:19:27 +0000  0.05) of DUT or FIN concentration for these endpoints.” “…Eight other compounds, including three other pharmaceutical steroidogenic enzyme inhibitors (Galeterone (GAL); CYP17A1 inhibitor, Trilostane (TRI); 3β-HSD inhibitor, Atorvastatin (ATO); HMG-CoA reductase inhibitor), one 5β-reductase inhibitor (Chenodeoxycholic acid (ChenA)), a mutagen (Benzoquinoline (BENZO)), and an anti-inflammatory chemical (γ-linolenic acid (y-LIN) were tested in the embryonic B. glabrata assay to assess whether the banana-shaped phenotype was specific to 5αR inhibitors, or if it was a general enzyme-inhibition or toxicity effect. None of the other compounds tested elicited the banana-shaped phenotype (Supporting Information Table S4, link here)…Dorsomorphin (DORS) was included as it had previously been reported to induce ‘immature shell-shape’ or cone-shaped (non-coiling) phenotypes in the gastropod Lymnaea stagnalis (at 0.5 and 1 µM, depending on exposure window)47, link here. However, no banana-shaped phenotype or non-coiling embryos were observed in any of the DORSO concentrations we tested (Supporting information Table S3, link here)…In summary, none of the other compounds tested (pharmaceutical enzyme inhibitors or experimental chemicals) induced the banana-shaped phenotype in developing B. glabrata embryos (Supporting information Tables 3, link here). Only the potent pharmaceutical 5αR inhibitors elicited the developmental effect of shell malformation. Which suggests that the 5αR inhibitors were specifically impacting a particular enzyme vital to B. glabrata morphological development.” “…To test whether the pharmaceutical 5αR inhibited phenotype was species-specific, a small experiment was conducted with a second freshwater gastropod species, Physella acuta. P. acuta embryos were developmentally exposed to solvent control, 100 and 200 µg/L DUT. This experiment induced strikingly similar results to B. glabrata, with 71.2 and 82.6% of the embryos developing the elongated banana-shaped phenotype in the 100 and 200 µg/L DUT respectively (Fig. 5, link here, Supporting information Table S5, link here). Both DUT doses tested produced significant induction (P < 0.0001) of banana-shaped snails compared to the solvent control, with the reciprocal reduction in normal shaped embryos. As seen with B. glabrata no significant effects of DUT dose were found for the number of non-specific malformations (P > 0.9999, P = 0.8770, respectively) or deaths (P = 0.9282, P > 0.9999, respectively).” “…A number of gastropods, such as those within the Vermetidae50, link here and the Caecidae families51, link here produce shells that are elongated in shape compared to typical coiled gastropod shells. Variation in coiling can also be seen within freshwater gastropods, and there is some debate about whether these curious findings are distinct species or if the unusual shell growth is a sporadic aberrant phenotype52, link here. Recent investigations into a corkscrew-like shell of the typically planispiral-shaped Gyraulus sp., discovered in a remote Tibetan lake, suggest these phenotypes are the result of as-yet-unknown ecological stressor rather than speciation52, link here. ” “…Here we demonstrate that pharmaceutical 5αR inhibitors induced a strong and highly reproducible phenotypic response in developing B. glabrata and P. acuta embryos that is not associated with toxicity. We have also confirmed that both 5αR homologues identified in B. glabrata are expressed during embryonic development and that antibodies raised against human 5αRs proteins are reactive in B. glabrata embryo extracts; this strongly suggests that pharmaceutical 5αR inhibitors could be acting on B. glabrata 5αR enzymes to cause this phenotypic disruption. In adult B. glabrata, 5αRs transcripts have been detected in mantle tissue32, link here. This is of note as molluscan shells are formed from secretory cells in the mantle21, link here, providing a possible link between 5αR and shell formation.”]]> 00:03:19 false https://haidut.me/?p=971 http://haidut.me/?p=971 Fri, 10 Apr 2020 16:59:21 +0000 00:02:19 false https://haidut.me/?p=968 http://haidut.me/?p=968 Thu, 09 Apr 2020 18:32:09 +0000 00:02:33 false https://haidut.me/?p=965 http://haidut.me/?p=965 Thu, 09 Apr 2020 17:25:23 +0000 00:02:07 false https://haidut.me/?p=962 http://haidut.me/?p=962 Tue, 07 Apr 2020 23:44:11 +0000 00:02:58 false https://haidut.me/?p=960 http://haidut.me/?p=960 Tue, 07 Apr 2020 23:13:54 +0000 00:01:54 false https://haidut.me/?p=958 http://haidut.me/?p=958 Tue, 07 Apr 2020 20:04:43 +0000 00:02:21 false https://haidut.me/?p=956 http://haidut.me/?p=956 Tue, 07 Apr 2020 18:09:33 +0000 00:01:01 false https://haidut.me/?p=952 http://haidut.me/?p=952 Tue, 07 Apr 2020 17:43:44 +0000 00:01:38 false https://haidut.me/?p=945 http://haidut.me/?p=945 Wed, 25 Mar 2020 19:00:25 +0000 00:02:31 false https://haidut.me/?p=941 http://haidut.me/?p=941 Sun, 22 Mar 2020 20:02:57 +0000 00:00:33 false https://haidut.me/?p=939 http://haidut.me/?p=939 Sun, 22 Mar 2020 19:53:40 +0000 00:01:15 false https://haidut.me/?p=937 http://haidut.me/?p=937 Sun, 22 Mar 2020 19:45:37 +0000 00:02:06 false https://haidut.me/?p=934 http://haidut.me/?p=934 Fri, 13 Mar 2020 17:47:20 +0000 00:02:34 false https://haidut.me/?p=932 http://haidut.me/?p=932 Fri, 13 Mar 2020 16:06:28 +0000 6 months and a weekly mean intensity score of >4 at baseline. The pain needed to be restricted to thoracic vertebrae 6 or below or associated with radiation to the proximal part of the lower limb.” “…Pain scores significantly improved in the pregnenolone group compared with placebo (Least-square mean [LSM] change in pain diary rating, -.56; P=.02; LSM change in pain recall, -.7; P=.01). Interference scores for work (LSM change, .71; P=.04) and activity (LSM change, .71; P=.03) were also improved in the pregnenolone group. Pregnenolone could serve as a safe and effective treatment to alleviate chronic low back pain in veterans, the study authors concluded.”]]> 00:01:31 false https://haidut.me/?p=930 http://haidut.me/?p=930 Thu, 05 Mar 2020 22:27:07 +0000 00:01:43 false https://haidut.me/?p=927 http://haidut.me/?p=927 Thu, 05 Mar 2020 21:04:21 +0000 00:01:16 false https://haidut.me/?p=925 http://haidut.me/?p=925 Thu, 05 Mar 2020 20:33:49 +0000 00:00:35 false https://haidut.me/?p=920 http://haidut.me/?p=920 Tue, 03 Mar 2020 18:13:14 +0000 00:03:02 false https://haidut.me/?p=912 http://haidut.me/?p=912 Mon, 02 Mar 2020 02:04:53 +0000 00:02:17 false https://haidut.me/?p=909 http://haidut.me/?p=909 Fri, 28 Feb 2020 19:53:19 +0000 00:01:24 false https://haidut.me/?p=907 http://haidut.me/?p=907 Fri, 28 Feb 2020 18:23:56 +0000 00:02:44 false https://haidut.me/?p=905 http://haidut.me/?p=905 Fri, 28 Feb 2020 17:31:57 +0000 inflammation/endotoxin/LPS->epilepsy – yet the public health authorities continue to act as if progesterone did not exist. The latest proposal from the National Institutes of Health (NIH) to test progesterone as a treatment for severe TBI was axed due to lack of funding. Yet, at the same time, billions were poured into the latest CRISPR abomination studies… 2 links here “…The development of epilepsy is a major clinical complication after brain injury, and the disease can often take years to appear.  “Working on rats, whose immune response system models that of humans, we identified that after brain injury a certain immune system receptor makes the brain more excitable, which promotes development of epilepsy,” said Viji Santhakumar, link here, an associate professor of molecular, cell, and systems biology, link here at UC Riverside and the lead author of the study, link here that appears in the Annals of Neurobiology. “If this receptor can be suppressed, preferably within a day after injury, the future development of epilepsy can be reduced if not entirely prevented.” The receptor in question is the Toll-like receptor 4, or TLR4, an innate immune receptor. Following a brain injury, TLR4 increases excitability in the dentate gyrus, link here of the hippocampus, the brain structure that plays a major role in learning and memory. Santhakumar explained two factors are involved in brain injury: a neurological complication and the immune system. These factors have traditionally been studied separately, she said. “Our team, however, studied these factors together,” she added. “This approach helped us understand that the immune system operates through a very different mechanism in the injured brain than in the uninjured brain. Understanding the difference can guide us on how best to target treatments aimed at preventing epilepsy after traumatic brain injury.” The team specifically studied concussions, the kind suffered by many football players, which can lead to cell death in the hippocampus, affecting the processing of memory. Cell death activates the immune system, including TLR4. TLR4, in turn, increases excitability in the hippocampus. “What our rat studies on traumatic brain injury show is that if we target early changes in excitability, we can alter long-term pathology,” Santhakumar said. “Blocking TLR4 signaling shortly after brain injury reduces neuronal excitability in the hippocampus and seizure susceptibility. This seizure susceptibility is not reduced if we delay the blocking of TLR4 signaling after injury.””]]> 00:03:17 false https://haidut.me/?p=903 http://haidut.me/?p=903 Wed, 26 Feb 2020 18:39:51 +0000 00:01:25 false https://haidut.me/?p=901 http://haidut.me/?p=901 Wed, 26 Feb 2020 18:18:28 +0000 00:02:20 false https://haidut.me/?p=899 http://haidut.me/?p=899 Wed, 26 Feb 2020 17:27:14 +0000 00:01:39 false https://haidut.me/?p=897 http://haidut.me/?p=897 Wed, 26 Feb 2020 00:45:35 +0000 00:04:05 false https://haidut.me/?p=893 http://haidut.me/?p=893 Tue, 25 Feb 2020 20:31:10 +0000 00:01:53 false https://haidut.me/?p=891 http://haidut.me/?p=891 Tue, 25 Feb 2020 19:30:37 +0000 00:02:07 false https://haidut.me/?p=889 http://haidut.me/?p=889 Tue, 25 Feb 2020 18:57:47 +0000 00:01:27 false https://haidut.me/?p=886 http://haidut.me/?p=886 Tue, 11 Feb 2020 19:48:13 +0000 00:03:58 false https://haidut.me/?p=884 http://haidut.me/?p=884 Mon, 10 Feb 2020 21:25:34 +0000 00:01:28 false https://haidut.me/?p=882 http://haidut.me/?p=882 Mon, 10 Feb 2020 21:11:52 +0000 00:04:09 false https://haidut.me/?p=875 http://haidut.me/?p=875 Thu, 06 Feb 2020 17:44:42 +0000 00:07:47 false https://haidut.me/?p=872 http://haidut.me/?p=872 Tue, 04 Feb 2020 20:45:52 +0000 00:01:59 false https://haidut.me/?p=870 http://haidut.me/?p=870 Tue, 04 Feb 2020 18:40:22 +0000 00:02:32 false https://haidut.me/?p=868 http://haidut.me/?p=868 Tue, 04 Feb 2020 16:39:33 +0000 00:05:14 false https://haidut.me/?p=866 http://haidut.me/?p=866 Mon, 03 Feb 2020 18:21:33 +0000 00:04:40 false https://haidut.me/?p=864 http://haidut.me/?p=864 Mon, 03 Feb 2020 17:27:08 +0000 00:01:15 false https://haidut.me/?p=862 http://haidut.me/?p=862 Thu, 30 Jan 2020 19:09:29 +0000 00:01:08 false https://haidut.me/?p=860 http://haidut.me/?p=860 Wed, 29 Jan 2020 20:22:11 +0000 00:01:47 false https://haidut.me/?p=858 http://haidut.me/?p=858 Wed, 29 Jan 2020 20:00:27 +0000 00:02:08 false https://haidut.me/?p=856 http://haidut.me/?p=856 Wed, 29 Jan 2020 19:08:43 +0000 00:02:29 false https://haidut.me/?p=853 http://haidut.me/?p=853 Sun, 19 Jan 2020 05:13:42 +0000 00:04:03 false https://haidut.me/?p=851 http://haidut.me/?p=851 Sun, 19 Jan 2020 01:26:27 +0000 00:01:43 false https://haidut.me/?p=849 http://haidut.me/?p=849 Sun, 19 Jan 2020 01:00:27 +0000 00:01:23 false https://haidut.me/?p=847 http://haidut.me/?p=847 Sun, 19 Jan 2020 00:40:14 +0000 00:02:26 false https://haidut.me/?p=845 http://haidut.me/?p=845 Sat, 18 Jan 2020 23:55:42 +0000 00:01:57 false https://haidut.me/?p=841 http://haidut.me/?p=841 Sat, 18 Jan 2020 23:10:45 +0000 00:02:28 false https://haidut.me/?p=839 http://haidut.me/?p=839 Sat, 18 Jan 2020 22:30:04 +0000 00:01:50 false https://haidut.me/?p=824 http://haidut.me/?p=824 Sun, 05 Jan 2020 20:05:40 +0000 00:03:27 false https://haidut.me/?p=820 http://haidut.me/?p=820 Thu, 02 Jan 2020 18:47:54 +0000 00:03:11 false https://haidut.me/?p=817 http://haidut.me/?p=817 Tue, 31 Dec 2019 04:56:33 +0000 00:02:23 false https://haidut.me/?p=815 http://haidut.me/?p=815 Mon, 30 Dec 2019 15:49:09 +0000 00:00:56 false https://haidut.me/?p=813 http://haidut.me/?p=813 Mon, 30 Dec 2019 15:22:33 +0000 00:11:46 false https://haidut.me/?p=811 http://haidut.me/?p=811 Sun, 29 Dec 2019 21:04:36 +0000 00:03:42 false https://haidut.me/?p=809 http://haidut.me/?p=809 Thu, 26 Dec 2019 19:11:42 +0000 00:01:41 false https://haidut.me/?p=807 http://haidut.me/?p=807 Mon, 23 Dec 2019 18:22:38 +0000 00:02:13 false https://haidut.me/?p=805 http://haidut.me/?p=805 Mon, 23 Dec 2019 18:02:41 +0000 00:02:04 false https://haidut.me/?p=803 http://haidut.me/?p=803 Mon, 23 Dec 2019 17:41:07 +0000 00:06:02 false https://haidut.me/?p=801 http://haidut.me/?p=801 Fri, 20 Dec 2019 18:41:42 +0000 00:02:36 false https://haidut.me/?p=794 http://haidut.me/?p=794 Fri, 13 Dec 2019 18:30:20 +0000 00:02:54 false https://haidut.me/?p=792 http://haidut.me/?p=792 Fri, 13 Dec 2019 17:46:49 +0000 00:01:45 false https://haidut.me/?p=790 http://haidut.me/?p=790 Fri, 13 Dec 2019 17:05:10 +0000 00:02:50 false https://haidut.me/?p=774 http://haidut.me/?p=774 Wed, 04 Dec 2019 20:35:28 +0000 00:01:02 false https://haidut.me/?p=767 http://haidut.me/?p=767 Wed, 04 Dec 2019 16:37:54 +0000 00:03:07 false https://haidut.me/?p=765 http://haidut.me/?p=765 Wed, 04 Dec 2019 01:14:44 +0000 00:01:29 false https://haidut.me/?p=763 http://haidut.me/?p=763 Wed, 04 Dec 2019 00:46:55 +0000 00:02:42 false https://haidut.me/?p=761 http://haidut.me/?p=761 Tue, 03 Dec 2019 00:23:41 +0000 00:02:09 false https://haidut.me/?p=759 http://haidut.me/?p=759 Mon, 02 Dec 2019 22:30:25 +0000 00:00:58 false https://haidut.me/?p=757 http://haidut.me/?p=757 Mon, 02 Dec 2019 22:17:41 +0000 00:02:13 false https://haidut.me/?p=755 http://haidut.me/?p=755 Mon, 02 Dec 2019 21:48:25 +0000 00:03:17 false https://haidut.me/?p=753 http://haidut.me/?p=753 Mon, 02 Dec 2019 18:29:32 +0000 00:02:10 false https://haidut.me/?p=749 http://haidut.me/?p=749 Mon, 02 Dec 2019 17:48:26 +0000 00:02:21 false https://haidut.me/?p=747 http://haidut.me/?p=747 Mon, 02 Dec 2019 17:21:21 +0000 00:01:16 false https://haidut.me/?p=745 http://haidut.me/?p=745 Wed, 27 Nov 2019 21:11:27 +0000 00:03:41 false https://haidut.me/?p=729 http://haidut.me/?p=729 Wed, 27 Nov 2019 20:12:06 +0000 00:02:31 false https://haidut.me/?p=742 http://haidut.me/?p=742 Tue, 26 Nov 2019 19:56:08 +0000 00:01:18 false https://haidut.me/?p=727 http://haidut.me/?p=727 Mon, 25 Nov 2019 00:49:16 +0000 00:02:31 false https://haidut.me/?p=725 http://haidut.me/?p=725 Sun, 24 Nov 2019 23:42:11 +0000 00:06:28 false https://haidut.me/?p=723 http://haidut.me/?p=723 Fri, 22 Nov 2019 20:35:28 +0000 00:03:14 false https://haidut.me/?p=719 http://haidut.me/?p=719 Fri, 22 Nov 2019 19:39:30 +0000 00:05:23 false https://haidut.me/?p=711 http://haidut.me/?p=711 Thu, 14 Nov 2019 18:06:39 +0000 00:01:17 false https://haidut.me/?p=709 http://haidut.me/?p=709 Thu, 14 Nov 2019 17:47:18 +0000 high serotonin -> lower dopamine -> higher serotonin, etc, etc. Serotonin is also the master controller of cortisol synthesis by regulating ACTH through the 5-HT2C receptor. Most successful antidepressants (and especially Prozac) are actually antagonists of 5-HT2C and as such lower ACTH (and thus baseline cortisol) and increase dopamine. Those drugs are still terribly toxic due to SSRI inhibition, but the key point here is that they treat depression by actually (partially) blocking the effects of serotonin at the receptor level (and as such lowering cortisol) and/or increasing dopamine levels. 2 links here That is only part of the story and it is well-hidden because even psychiatrists are not aware of the partial anti-serotonin effects of these drugs and continue to parrot idiotically whatever pharma reps feed them. However, despite the ongoing propaganda that serotonin is still the “happy hormone”, multiple Big Pharma companies (led by Pfizer and its drug antiserotonin drug terguride) are currently running clinical trials with a variety of drugs that either block serotonin at the receptor level (e.g. terguride) or inhibit its synthesis by blocking TPH. These trials cover diverse, serious chronic conditions spanning the spectrum of diabetes, morbid obesity, pulmonary arterial hypertension (PAH), heart failure / fibrosis, Alzheimer Disease (AD), Parkinson Disease (PD, infectious disease like Ebola or even HIV, and many more. And based on even a single study like the one below, we can immediately see that all of these conditions can stem from something as “benign” or even mundane and widely accepted as chronic stress. 2 links here “…We already know that chronic psychosocial adversity can induce vulnerability to mental illnesses such as schizophrenia and depression,” explains lead author Dr Michael Bloomfield, Excellence Fellow and leader of the Translational Psychiatry Research Group at University College London, UK. “What we’re missing is a precise mechanistic understanding of how this risk is increased.” To address this question, Dr Bloomfield and his colleagues used an imaging technique called positron emission tomography (PET) to compare the production of dopamine in 34 volunteers exposed to an acute stress. Half of the participants had a high lifetime exposure to psychosocial stress, while the other half had low exposure. All of them undertook the Montréal Imaging Stress Task, which involved receiving criticism as they tried to complete mental arithmetic. Two hours after this stress task, the participants were injected with small amounts of a radioactive tracer that allowed the scientists to view dopamine production in their brains using PET. The scans revealed that in those with low exposure to chronic adversity, dopamine production was proportional to the degree of threat that the person perceived.” “…In people with high exposure to chronic adversity, however, the perception of threat was exaggerated whilst their production of dopamine was impaired. The researchers found that other physiological responses to stress were also dampened in this group. For example, their blood pressure and cortisol levels did not increase as much as in the low-adversity group in response to stress. “This study can’t prove that chronic psychosocial stress causes mental illness or substance abuse later in life by lowering dopamine levels,” Dr Bloomfield cautions. “But we have provided a plausible mechanism for how chronic stress may increase the risk of mental illnesses by altering the brain’s dopamine system.”]]> 00:04:48 false https://haidut.me/?p=705 http://haidut.me/?p=705 Wed, 13 Nov 2019 18:42:00 +0000 00:03:37 false https://haidut.me/?p=703 http://haidut.me/?p=703 Wed, 13 Nov 2019 17:21:19 +0000 00:02:00 false https://haidut.me/?p=701 http://haidut.me/?p=701 Wed, 13 Nov 2019 16:56:34 +0000 00:03:52 false https://haidut.me/?p=696 http://haidut.me/?p=696 Fri, 08 Nov 2019 17:01:42 +0000 00:01:26 false https://haidut.me/?p=694 http://haidut.me/?p=694 Fri, 08 Nov 2019 16:23:51 +0000 00:02:21 false https://haidut.me/?p=692 http://haidut.me/?p=692 Fri, 08 Nov 2019 15:41:47 +0000 00:01:18 false https://haidut.me/?p=690 http://haidut.me/?p=690 Fri, 08 Nov 2019 01:05:08 +0000 00:02:15 false https://haidut.me/?p=688 http://haidut.me/?p=688 Fri, 08 Nov 2019 00:34:49 +0000 00:04:52 false https://haidut.me/?p=686 http://haidut.me/?p=686 Wed, 06 Nov 2019 21:07:29 +0000 00:01:45 false https://haidut.me/?p=684 http://haidut.me/?p=684 Wed, 06 Nov 2019 20:10:28 +0000 00:01:59 false https://haidut.me/?p=682 http://haidut.me/?p=682 Wed, 06 Nov 2019 18:41:02 +0000 00:02:18 false https://haidut.me/?p=680 http://haidut.me/?p=680 Wed, 06 Nov 2019 17:58:51 +0000 00:01:09 false https://haidut.me/?p=678 http://haidut.me/?p=678 Wed, 06 Nov 2019 17:33:16 +0000 00:02:01 false https://haidut.me/?p=676 http://haidut.me/?p=676 Wed, 06 Nov 2019 16:50:54 +0000 00:02:18 false https://haidut.me/?p=668 http://haidut.me/?p=668 Tue, 22 Oct 2019 16:51:46 +0000 80% in diabetes and strongly correlated with changes in NEFA, consistent with their liberation during adipose lipolysis. Endocannabinoid behavior differed by class with diabetes increasing an array of N-acylethanolamides which were positively correlated with pro-inflammatory 5-lipooxygenase-derived metabolites, while monoacylglycerols were negatively correlated with body mass. These results clearly show that diabetes not only results in an increase in plasma NEFA, but shifts the plasma lipidomic profiles in ways that reflect the biochemical and physiological changes of this pathological state which are independent of obesity associated changes.” None of this is even remotely theoretical, as many other recent studies I have discussed in this blog have already confirmed that increased fatty acid oxidation drives most of the organ failures seen in diabetic patients. While kidney failure is the most-often cited example of lipolysis-induced organ failure, the destruction of the beta-cells in the pancreas, dementias, movement disorders (Parkinson, Huntington, etc), CVD, osteoporosis, hypogonadism, etc have all been tied to excessive (or prolonged) FFA exposure. In light of the studies discussed in this blog, I think we can safely reclassify all of these pathologies as due to PUFA exposure/overload. The takeaway of this post is the following. If a person consumes a diet high on fat (e.g. >15% of daily calories) with a PUFA fraction above a certain critical level (I suspect that number is around 10% of total fat), over time their fat stores will increase and will be composed predominantly of PUFA. In addition, any time such a person is exposed to stress, fasting, exhaustive exercise, infection, or really any other event that results in increased lipolysis their bloodstream will be flooded with FFA consisting mostly of PUFA. This elevated lipolysis (if maintained chronically) will at best result in liver disease and at worst in all the degenerative changes seen in conditions such as diabetes, CVD, neurodegenerative diseases and even cancer. As such, fasting and/or exhaustive exercise are one of the worst things an overweight person can do as it will only lead to a prolonged PUFA exposure and the resulting suppression of glucose oxidation, increased inflammation and ultimately severe chronic disease. A healthy approach to this problem for an obese/overweight/diabetic person would be to (1) lower total fat intake; (2) ensure SFA/PUFA ratio is as high as practically possible; (3) protect the liver and other organs from excessive lipolysis (niacinamide, aspirin, vitamin E); (4) support hormonal environment that resists weight gain (e.g. keep cortisol/estrogen at bay and pregnenolone/progesterone/DHEA/T/DHT at optimal levels). If these guidelines are followed, over time the muscles should be able to oxidize the stored PUFA and the liver should be able to glucuronidate whatever the muscles cannot handle. link here “…Although there is no definitive mechanism explaining how SFAs induce ER stress, increasing evidence points to disordered phospholipid metabolism as one initiating factor. Unsaturated fatty acids are readily incorporated into inert TGs, but excess SFAs remain largely unesterified [28, link here]. Recent literature suggests that these free SFAs are rapidly assembled into saturated phospholipid species that are subsequently integrated into ER membrane bilayers [46, link here].” link here “…This previous study showed that SFA and MUFA levels are strongly reduced, while PUFA accumulates, in blunt snout bream fed a 15% fat diet [9], link here. SFA and MUFA in fish are preferentially used as oxidation substrates through the mitochondrial pathway, whereas this is not the case for PUFA [45], link here. Thus, it is predicted that decreased FA oxidation will not only affect lipid levels, but also the FA content of the liver.” link here “…Beta-oxidation was studied in red muscle mitochondria of 10 major fatty acids that are acquired in the diet and occur in the fat depots of rainbow trout (Oncorhynchus mykiss Walbaum). The mitochondria were isolated by fractional centrifugation and the fatty acids were added as coenzyme A esters in the presence of carnitine. The fatty acids could be separated into roughly three groups in relation to their oxidation rates. Two fatty acids (14:0 and 16:0) were oxidized as rapidly as pyruvate. Another six acids (16:1 n − 7, 18:0, 18:1 n − 9, 20:1 n − 9, 22:1 n − 9 and 22:6 n − 3) were oxidized at about three-quarters to one-half the rate of pyruvate. The two essential fatty acids (18:2 n − 6 and 18:3 n − 3) had a slow oxidation rate, about one-fifth of that of pyruvate. The liver mitochondria from rainbow trout oxidized 18:0, 18:1, 18:2, and 18:3 at the same rate, 70–80% of that of pyruvate. These results show that rainbow trout red muscle discriminates between fatty acids used in energy production and essential fatty acid precursors, as indicated by the low β-oxidation rate of the latter acids.”]]> 00:05:51 false https://haidut.me/?p=666 http://haidut.me/?p=666 Mon, 21 Oct 2019 19:06:25 +0000 00:05:53 false https://haidut.me/?p=664 http://haidut.me/?p=664 Sun, 20 Oct 2019 22:49:10 +0000 00:02:13 false https://haidut.me/?p=660 http://haidut.me/?p=660 Sun, 20 Oct 2019 20:20:52 +0000 00:05:10 false https://haidut.me/?p=655 http://haidut.me/?p=655 Thu, 17 Oct 2019 15:34:24 +0000 serotonin). This results in increased serotonin availability/buildup since the primary role of SERT/5-HTT is to deactivate serotonin, using sodium as a co-factor. link here “…The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein, link here that in humans is encoded by the SLC6A4 gene, link here.[5], link here SERT is a type of monoamine transporter, link here protein, link here that transports, link here serotonin from the synaptic cleft, link here back to the presynaptic neuron.[6], link hereThis transport of serotonin, link here by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is the target of many antidepressant medications of the SSRI, link here and tricyclic antidepressant, link here classes.[7]”, link here What’s even worse, the study demonstrates that serotonin and AA form a positive feedback cycle with the increased serotonin due to AA inhibiting SERT/5-HTT resulting in activation of the enzyme Phospholipase A2 (PLA2), link here that synthesizes AA from linoleic acid, which then results in stronger SERT/5-HTT inhbition and even higher serotonin availability. While the study tries to dance carefully around the role of serotonin in depression and states that “conflicting” results have been seen in other studies, it readily admits that AA is a known inducer of depression in animal models. Well, if AA is a highly inflammatory depressant and forms a positive feedback cycle with serotonin then I don’t see how serotonin could possibly be an anti-depressant…Another immediate takeaway from the study is that SSRI drugs are highly pro-inflammatory since they activate the AA<->serotonin cycle by inhibiting SERT/5-HTT (which is their primary mechanism of action). All in all, another great reason to avoid PUFA and eat plenty of salt (to taste). link here “…The relative peripheral levels of PUFA species are associated with neuropsychiatric illnesses, with elevated AA in proportion to DHA and EPA in MDD (Lin et al., 2010) and suicide risk (Huan et al., 2004; Lewis et al., 2011; Sublette et al., 2006). AA is particularly implicated in bipolar disorder, both postmortem (Kim et al., 2009) and in translational studies showing that multiple mood stabilizing medications downregulate AA metabolism (Rapoport, 2014).” “…We have previously reported lower 5-HTT binding (BPP), using positron emission tomography (PET) and [11C]McN5652, in unmedicated MDD (Parsey et al., 2006a) and bipolar depressed (Oquendo et al., 2007a) groups compared with healthy controls. [11C]…We have reported lower [11C]DASB binding (VT/fP) in MDD patients with a history of suicide attempt (Miller et al., 2013), and lower binding potentials (BPF, BPP, and BPND, using a suboptimal reference region) in bipolar depression (Miller et al., 2016), considering a priori regions of interest (ROIs), although VT/fP did not differ in that study. ” “…Separate models testing effects of DHA, EPA, and AA revealed no effects of DHA nor EPA on [11C]DASB binding potential (data not shown). However, AA had an effect on BPP (F = 9.14; df=1,19; p = 0.006) across regions, and given graphical evidence of a nonlinear relationship between AA level and BPP (Fig. 1A), we found that an added quadratic term was significant (F = 9.62; df=1,19; p = 0.006; also see Fig. 4, path a). The resulting inverted U-shaped relationship demonstrates that for most of the concentration range of AA, higher BPP correlated with lower AA levels. Exploratory analyses of PUFA effects on BPND and BPF (see Fig. 1B and C) similarly found that AA, but not DHA or EPA, demonstrated a comparable effect on BPND (F = 7.40; df=1,19; p = 0.014) while controlling for region, but had no statistically significant effect on BPF (F = 0.51; df=1,19; p = 0.484).” “…Specifically, 5-HT2A/2C stimulates activation of cytosolic phospholipase A2 (cPLA2) (Berg et al., 1998; Qu et al., 2005; Garcia and Kim, 1997; Felder et al., 1990), triggering the release of unesterified AA from membrane phospholipids. Some of the released AA is recycled back into the membrane, a process that is stimulated by 5-HT1A receptors (Strosznajder et al., 1996). Remaining unesterified AA can decrease 5-HTT in certain brain regions (du Bois et al., 2006).” link here “…Drs. Sublette, Mann and colleagues including Gregory Sullivan, M.D., link here, a 2004 BBRF Young Investigator, discovered in their study that only one of the PUFAs they measured—AA, or arachidonic acid—had a potential impact on the availability of SERTs across the six brain areas that were imaged via PET scan. Specifically, they found that greater SERT availability in neurons correlated with lower AA levels in subjects, as measured in their plasma prior to the scans. This result led the team to hypothesize that AA may affect the severity of depression through its impact on the availability of SERTs in the brain. The nature of the observed correlation was complex, with extreme levels of AA affecting both SERTs and depression severity differently than moderate AA levels.”]]> 00:00:46 false https://haidut.me/?p=653 http://haidut.me/?p=653 Thu, 17 Oct 2019 00:54:40 +0000 00:08:27 false https://haidut.me/?p=648 http://haidut.me/?p=648 Fri, 11 Oct 2019 20:40:26 +0000 00:01:34 false https://haidut.me/?p=646 http://haidut.me/?p=646 Fri, 11 Oct 2019 20:05:38 +0000 00:00:42 false https://haidut.me/?p=644 http://haidut.me/?p=644 Fri, 11 Oct 2019 00:52:08 +0000 00:03:40 false https://haidut.me/?p=642 http://haidut.me/?p=642 Thu, 10 Oct 2019 21:09:25 +0000 00:04:11 false https://haidut.me/?p=640 http://haidut.me/?p=640 Thu, 10 Oct 2019 19:59:33 +0000 00:01:05 false https://haidut.me/?p=635 http://haidut.me/?p=635 Thu, 10 Oct 2019 18:00:02 +0000 00:03:13 false https://haidut.me/?p=633 http://haidut.me/?p=633 Thu, 10 Oct 2019 16:19:42 +0000 00:01:02 false https://haidut.me/?p=630 http://haidut.me/?p=630 Thu, 03 Oct 2019 19:45:59 +0000 00:00:59 false https://haidut.me/?p=628 http://haidut.me/?p=628 Thu, 03 Oct 2019 19:03:43 +0000 00:03:58 false https://haidut.me/?p=626 http://haidut.me/?p=626 Thu, 03 Oct 2019 15:34:43 +0000 00:01:34 false https://haidut.me/?p=583 http://haidut.me/?p=583 Mon, 23 Sep 2019 19:25:31 +0000 200mm^3 were castrated, randomized in 5 groups and treatment with Docetaxel i.p. (40 mg/kg), Docetaxel and Estradiol in on-off schedule (High-dose: 1mg/kg or low-dose: 0.1mg/kg s.c., one week on, one week off) or Docetaxel and DHT (1mg/kg – on schedule weekly) started when tumors were considered as androgen independent. Mice were sacrificed when they were compromised by excessive tumor load. Yumors were harvested and immunohistochemical staining for ERb, AR, PSA, Ki-67 and Nek2 performed.” “…Results: Tumor growth was 2 fold increased in the high-dose E2 and low-dose E2 treated group compared to the control group. Interestingly, combination therapy of DHT and docetaxel caused a signficant reduction of tumor volume (30%-50%) and tumors <250mm^3 disappeared. Tumor size in docetaxel treated mice could only be stabilized over 2 cycles. Immunohistochemical  staining showed a correlation of ERb expression, expression of Nek2 and AR in high-dose E2 treated mice and DHT treated mice.” “…Conclusions: Combination of docetaxel and intermittent DHT application reduced tumor volume significantly in this animal model. DHT might promote chemosensitivity to docetaxel by complex modulation of ERb, AR and mitotic kinases like Nek2.”]]> 00:03:14 false https://haidut.me/?p=574 http://haidut.me/?p=574 Fri, 20 Sep 2019 17:23:22 +0000 00:03:00 false https://haidut.me/?p=563 http://haidut.me/?p=563 Wed, 18 Sep 2019 19:58:36 +0000 00:04:03 false https://haidut.me/?p=561 http://haidut.me/?p=561 Wed, 18 Sep 2019 16:04:26 +0000 00:01:51 false https://haidut.me/?p=559 http://haidut.me/?p=559 Wed, 18 Sep 2019 15:32:33 +0000 00:00:47 false https://haidut.me/?p=557 http://haidut.me/?p=557 Wed, 18 Sep 2019 14:12:41 +0000 00:03:17 false https://haidut.me/?p=546 http://haidut.me/?p=546 Fri, 13 Sep 2019 18:54:12 +0000 00:17:41 false https://haidut.me/?p=542 http://haidut.me/?p=542 Thu, 12 Sep 2019 16:54:52 +0000 00:01:51 false https://haidut.me/?p=538 http://haidut.me/?p=538 Thu, 12 Sep 2019 15:56:31 +0000 00:02:49 false https://haidut.me/?p=527 http://haidut.me/?p=527 Fri, 06 Sep 2019 15:22:55 +0000 00:02:14 false https://haidut.me/?p=524 http://haidut.me/?p=524 Fri, 06 Sep 2019 14:59:26 +0000 00:02:52 false https://haidut.me/?p=522 http://haidut.me/?p=522 Fri, 06 Sep 2019 14:47:16 +0000 stroke) that the odd findings of lower CVD risk are likely either a fluke or deliberate manipulation to avoid destroying completely the massive industry that has formed to cater to the plant-eaters. I also don’t buy the explanation of low iron intake or vitamin B12 deficiency as causes of the higher stroke risk. Most people actually have much higher than optimal levels of iron in tissues, and iron toxicity is a known risk factor for both ischemic and hemorrhaging strokes. The same is likely true about vitamin B12. Considering the microbiome can synthesize B12 and the fact that most people have either SIBO or some form of colon dysbiosis, B12 deficiencies are very rare. In fact, many people who have tested their B12 often find that their levels are either high or at the very top of the normal range. Elevated B12 levels have been ties to higher risk for some cancers and also strokes. As a follow up, I would like to see a study on hormonal changes as a result of different diets as that would likely expose just how “benign” estrogen is and how ubiquitous estrogenic molecules are in nature. Given the recent studies that bravely exposed estrogen as a cause of autism I have some hope that such hormonal studies can be happen even if Big Agriculture led by Monsanto spends billions every year to prevent them from seeing the light of day. 2 links here “…It analyses data from the EPIC-Oxford study, a major long-term research project looking at diet and health. Half of participants, recruited between 1993 and 2001, were meat-eaters, just over 16,000 vegetarian or vegan, with 7,500 who described themselves as pescatarian (fish-eating). They were asked about their diets, when they joined the study and again in 2010. Medical history, smoking and physical activity were taken into account, Altogether, there were 2,820 cases of coronary heart disease (CHD) and 1,072 cases of stroke – including 300 haemorrhagic strokes, which happen when a weakened blood vessel bursts and bleeds into the brain. The pescatarians were found to have a 13% lower risk of CHD than the meat-eaters, while the vegetarians and vegans had a 22% lower risk. But those on plant-based diets had a 20% higher risk of stroke. The researchers suggested this could be linked to low vitamin B12 levels but said more studies were needed to investigate the connection.”]]> 00:02:21 false https://haidut.me/?p=519 http://haidut.me/?p=519 Wed, 04 Sep 2019 16:16:45 +0000 00:02:45 false https://haidut.me/?p=517 http://haidut.me/?p=517 Wed, 04 Sep 2019 15:47:39 +0000 00:00:47 false https://haidut.me/?p=515 http://haidut.me/?p=515 Wed, 04 Sep 2019 15:34:51 +0000 00:02:24 false https://haidut.me/?p=513 http://haidut.me/?p=513 Wed, 04 Sep 2019 14:56:37 +0000 00:01:08 false https://haidut.me/?p=500 http://haidut.me/?p=500 Tue, 27 Aug 2019 15:24:33 +0000 00:01:58 false https://haidut.me/?p=498 http://haidut.me/?p=498 Tue, 27 Aug 2019 14:25:25 +0000 00:00:59 false https://haidut.me/?p=490 http://haidut.me/?p=490 Thu, 22 Aug 2019 19:11:06 +0000 00:01:24 false https://haidut.me/?p=488 http://haidut.me/?p=488 Thu, 22 Aug 2019 18:58:54 +0000 00:00:53 false https://haidut.me/?p=486 http://haidut.me/?p=486 Thu, 22 Aug 2019 18:48:14 +0000 00:01:11 false https://haidut.me/?p=484 http://haidut.me/?p=484 Thu, 22 Aug 2019 18:32:08 +0000 00:02:19 false https://haidut.me/?p=482 http://haidut.me/?p=482 Thu, 22 Aug 2019 18:10:04 +0000 00:02:07 false https://haidut.me/?p=480 http://haidut.me/?p=480 Thu, 22 Aug 2019 17:50:23 +0000 00:01:42 false https://haidut.me/?p=476 http://haidut.me/?p=476 Thu, 22 Aug 2019 17:22:55 +0000 00:01:38 false https://haidut.me/?p=472 http://haidut.me/?p=472 Mon, 05 Aug 2019 06:13:15 +0000 00:02:04 false https://haidut.me/?p=470 http://haidut.me/?p=470 Sat, 03 Aug 2019 23:01:16 +0000 00:01:20 false https://haidut.me/?p=467 http://haidut.me/?p=467 Fri, 02 Aug 2019 17:31:40 +0000 00:01:17 false https://haidut.me/?p=465 http://haidut.me/?p=465 Fri, 02 Aug 2019 17:02:59 +0000 00:00:44 false https://haidut.me/?p=444 http://haidut.me/?p=444 Mon, 29 Jul 2019 17:35:13 +0000 00:03:56 false https://haidut.me/?p=441 http://haidut.me/?p=441 Sat, 27 Jul 2019 21:22:01 +0000 00:01:52 false https://haidut.me/?p=437 http://haidut.me/?p=437 Fri, 26 Jul 2019 20:37:04 +0000 00:01:44 false https://haidut.me/?p=434 http://haidut.me/?p=434 Fri, 26 Jul 2019 20:16:56 +0000 00:02:36 false https://haidut.me/?p=431 http://haidut.me/?p=431 Fri, 26 Jul 2019 17:22:14 +0000 00:02:54 false https://haidut.me/?p=428 http://haidut.me/?p=428 Fri, 26 Jul 2019 17:04:28 +0000 00:00:42 false https://haidut.me/?p=424 http://haidut.me/?p=424 Fri, 26 Jul 2019 16:44:09 +0000 00:01:06 false https://haidut.me/?p=421 http://haidut.me/?p=421 Fri, 26 Jul 2019 16:23:21 +0000 00:01:27 false https://haidut.me/?p=418 http://haidut.me/?p=418 Thu, 18 Jul 2019 19:35:32 +0000 00:01:50 false https://haidut.me/?p=415 http://haidut.me/?p=415 Wed, 17 Jul 2019 18:15:53 +0000 00:02:00 false https://haidut.me/?p=411 http://haidut.me/?p=411 Wed, 17 Jul 2019 16:54:40 +0000 00:01:26 false https://haidut.me/?p=391 http://haidut.me/?p=391 Tue, 16 Jul 2019 01:35:16 +0000 00:01:56 false https://haidut.me/?p=388 http://haidut.me/?p=388 Tue, 16 Jul 2019 01:15:02 +0000 00:01:46 false https://haidut.me/?p=385 http://haidut.me/?p=385 Mon, 15 Jul 2019 21:01:12 +0000 00:02:19 false https://haidut.me/?p=242 http://haidut.me/?p=242 Sat, 13 Jul 2019 23:34:01 +0000 00:01:04 false https://haidut.me/?p=239 http://haidut.me/?p=239 Fri, 12 Jul 2019 16:59:20 +0000 00:03:23 false https://haidut.me/?p=237 http://haidut.me/?p=237 Wed, 10 Jul 2019 04:26:16 +0000 00:01:27 false https://haidut.me/?p=234 http://haidut.me/?p=234 Wed, 10 Jul 2019 03:04:33 +0000 00:02:59 false https://haidut.me/?p=232 http://haidut.me/?p=232 Wed, 10 Jul 2019 02:09:42 +0000 00:01:16 false https://haidut.me/?p=230 http://haidut.me/?p=230 Wed, 10 Jul 2019 01:47:15 +0000 00:01:19 false https://haidut.me/?p=228 http://haidut.me/?p=228 Wed, 10 Jul 2019 00:41:26 +0000 00:00:41 false https://haidut.me/?p=226 http://haidut.me/?p=226 Wed, 10 Jul 2019 00:21:50 +0000 00:01:32 false https://haidut.me/?p=223 http://haidut.me/?p=223 Wed, 26 Jun 2019 23:27:43 +0000 00:00:41 false https://haidut.me/?p=221 http://haidut.me/?p=221 Wed, 26 Jun 2019 23:08:21 +0000 00:01:44 false https://haidut.me/?p=219 http://haidut.me/?p=219 Tue, 25 Jun 2019 19:44:33 +0000 00:04:56 false https://haidut.me/?p=217 http://haidut.me/?p=217 Tue, 18 Jun 2019 18:31:26 +0000 00:01:03 false https://haidut.me/?p=215 http://haidut.me/?p=215 Sun, 16 Jun 2019 21:10:21 +0000 00:01:17 false https://haidut.me/?p=213 http://haidut.me/?p=213 Sun, 16 Jun 2019 20:55:29 +0000 00:00:30 false https://haidut.me/?p=203 http://haidut.me/?p=203 Thu, 13 Jun 2019 19:46:17 +0000 00:03:13 false https://haidut.me/?p=200 http://haidut.me/?p=200 Thu, 13 Jun 2019 16:31:31 +0000 00:02:26 false https://haidut.me/?p=198 http://haidut.me/?p=198 Thu, 13 Jun 2019 01:24:34 +0000 00:01:18 false https://haidut.me/?p=196 http://haidut.me/?p=196 Thu, 13 Jun 2019 01:14:28 +0000 00:01:15 false https://haidut.me/?p=194 http://haidut.me/?p=194 Thu, 13 Jun 2019 00:53:06 +0000 00:02:21 false https://haidut.me/?p=192 http://haidut.me/?p=192 Thu, 13 Jun 2019 00:44:37 +0000 00:03:23 false https://haidut.me/?p=180 http://haidut.me/?p=180 Tue, 04 Jun 2019 19:15:19 +0000 00:02:17 false https://haidut.me/?p=177 http://haidut.me/?p=177 Tue, 04 Jun 2019 18:36:13 +0000 00:02:07 false https://haidut.me/?p=174 http://haidut.me/?p=174 Sat, 01 Jun 2019 00:46:02 +0000 00:03:03 false https://haidut.me/?p=171 http://haidut.me/?p=171 Sat, 01 Jun 2019 00:19:31 +0000 00:10:20 false https://haidut.me/?p=168 http://haidut.me/?p=168 Thu, 30 May 2019 17:43:34 +0000 00:01:08 false https://haidut.me/?p=166 http://haidut.me/?p=166 Thu, 30 May 2019 16:11:07 +0000 00:03:01 false https://haidut.me/?p=164 http://haidut.me/?p=164 Thu, 30 May 2019 13:59:58 +0000 00:01:58 false https://haidut.me/?p=154 http://haidut.me/?p=154 Thu, 23 May 2019 13:14:02 +0000 00:01:44 false https://haidut.me/?p=151 http://haidut.me/?p=151 Thu, 23 May 2019 12:07:52 +0000 00:00:49 false https://haidut.me/?p=148 http://haidut.me/?p=148 Thu, 23 May 2019 11:53:14 +0000 1). High expression of either TLR4 or PD-L1 indicated a poor survival rate for patients with PTCL. Multivariate analyses further confirmed that increased expression levels of TLR4 and PD-L1 are unfavorable prognostic factors for PTCL.”]]> 00:00:27 false https://haidut.me/?p=146 http://haidut.me/?p=146 Thu, 23 May 2019 11:48:04 +0000 00:02:04 false https://haidut.me/?p=144 http://haidut.me/?p=144 Thu, 23 May 2019 11:31:05 +0000 00:02:19 false https://haidut.me/?p=141 http://haidut.me/?p=141 Thu, 23 May 2019 11:04:47 +0000 00:02:35 false https://haidut.me/?p=139 http://haidut.me/?p=139 Thu, 16 May 2019 21:34:59 +0000 00:01:20 false https://haidut.me/?p=129 http://haidut.me/?p=129 Thu, 16 May 2019 16:21:26 +0000 00:03:22 false https://haidut.me/?p=127 http://haidut.me/?p=127 Wed, 15 May 2019 20:04:25 +0000 00:01:19 false https://haidut.me/?p=125 http://haidut.me/?p=125 Wed, 15 May 2019 19:52:38 +0000 00:01:44 false https://haidut.me/?p=118 http://haidut.me/?p=118 Fri, 10 May 2019 17:44:09 +0000 00:01:13 false https://haidut.me/?p=116 http://haidut.me/?p=116 Fri, 10 May 2019 17:26:24 +0000 00:00:54 false https://haidut.me/?p=113 http://haidut.me/?p=113 Fri, 10 May 2019 16:54:21 +0000 00:03:41 false https://haidut.me/?p=111 http://haidut.me/?p=111 Fri, 10 May 2019 16:19:07 +0000 00:01:51 false https://haidut.me/?p=109 http://haidut.me/?p=109 Thu, 09 May 2019 16:22:45 +0000 00:00:47 false https://haidut.me/?p=107 http://haidut.me/?p=107 Thu, 09 May 2019 01:04:15 +0000 00:01:33 false https://haidut.me/?p=104 http://haidut.me/?p=104 Thu, 09 May 2019 00:48:00 +0000 00:01:04 false https://haidut.me/?p=102 http://haidut.me/?p=102 Thu, 09 May 2019 00:21:46 +0000 00:01:45 false https://haidut.me/?p=100 http://haidut.me/?p=100 Wed, 08 May 2019 19:39:25 +0000 00:00:59 false https://haidut.me/?p=98 http://haidut.me/?p=98 Wed, 08 May 2019 19:26:59 +0000 00:02:04 false https://haidut.me/?p=95 http://haidut.me/?p=95 Wed, 08 May 2019 19:17:57 +0000 00:01:39 false https://haidut.me/?p=93 http://haidut.me/?p=93 Mon, 06 May 2019 18:58:12 +0000 00:00:50 false https://haidut.me/?p=91 http://haidut.me/?p=91 Mon, 06 May 2019 18:43:16 +0000 00:01:14 false https://haidut.me/?p=86 http://haidut.me/?p=86 Sat, 04 May 2019 21:44:10 +0000 00:04:26 false https://haidut.me/?p=84 http://haidut.me/?p=84 Fri, 03 May 2019 18:27:21 +0000 00:01:29 false https://haidut.me/?p=82 http://haidut.me/?p=82 Fri, 03 May 2019 17:07:44 +0000 00:00:52 false https://haidut.me/?p=80 http://haidut.me/?p=80 Wed, 01 May 2019 19:50:01 +0000 00:01:09 false https://haidut.me/?p=78 http://haidut.me/?p=78 Wed, 01 May 2019 19:39:08 +0000 00:01:55 false https://haidut.me/?p=76 http://haidut.me/?p=76 Wed, 24 Apr 2019 15:21:47 +0000 00:00:55 false https://haidut.me/?p=67 http://haidut.me/?p=67 Tue, 23 Apr 2019 19:13:33 +0000 00:02:29 false https://haidut.me/?p=65 http://haidut.me/?p=65 Tue, 23 Apr 2019 17:20:07 +0000 00:01:02 false https://haidut.me/?p=63 http://haidut.me/?p=63 Tue, 23 Apr 2019 17:09:58 +0000 00:01:37 false https://haidut.me/?p=61 http://haidut.me/?p=61 Wed, 17 Apr 2019 19:46:33 +0000 00:01:19 false https://haidut.me/?p=59 http://haidut.me/?p=59 Tue, 16 Apr 2019 17:59:25 +0000 00:02:09 false https://haidut.me/?p=56 http://haidut.me/?p=56 Mon, 15 Apr 2019 16:13:08 +0000 00:01:52 false https://haidut.me/?p=51 http://haidut.me/?p=51 Fri, 12 Apr 2019 19:56:22 +0000 00:01:28 false https://haidut.me/?p=49 http://haidut.me/?p=49 Fri, 12 Apr 2019 19:42:03 +0000 00:02:49 false https://haidut.me/?p=47 http://haidut.me/?p=47 Fri, 12 Apr 2019 19:05:41 +0000 00:00:53 false https://haidut.me/?p=45 http://haidut.me/?p=45 Fri, 12 Apr 2019 18:52:42 +0000 00:01:30 false https://haidut.me/?p=43 http://haidut.me/?p=43 Fri, 12 Apr 2019 18:39:27 +0000 00:02:38 false https://haidut.me/?p=41 http://haidut.me/?p=41 Fri, 12 Apr 2019 18:21:21 +0000 00:00:31 false https://haidut.me/?p=38 http://haidut.me/?p=38 Fri, 12 Apr 2019 18:12:31 +0000 00:02:36 false https://haidut.me/?p=19 http://haidut.me/?p=19 Thu, 11 Apr 2019 15:28:35 +0000 00:00:57 false https://haidut.me/?p=17 http://haidut.me/?p=17 Thu, 11 Apr 2019 14:40:41 +0000 00:03:36 false https://haidut.me/?p=14 http://haidut.me/?p=14 Thu, 11 Apr 2019 14:36:23 +0000 00:03:22 false https://haidut.me/?p=1 http://haidut.dyndns.org/wordpress/?p=1 Wed, 10 Apr 2019 17:43:42 +0000 00:00:14 false