https://podcast.carverupton.com/saladino en-us Unofficial audio narration of Paul Saladino MD's email newsletter, generated automatically with local text-to-speech. Not affiliated with him. Paul Saladino MD (unofficial audio mirror) carver.upton@gmail.com false https://podcast.carverupton.com/saladino/cover.jpg?v=1791318861 https://podcast.carverupton.com/saladino Wed, 14 Oct 2026 14:25:06 +0000 <01M4X73H2TW4QQJ57MH5SM6E7T@klaviyomail.com> Wed, 14 Oct 2026 13:01:14 +0000 00:05:53 false <01M4NT724CAW2MPXR4G01FAQDX@klaviyomail.com> Sun, 11 Oct 2026 16:05:13 +0000 00:11:33 false <01M4B6AF1GRGHPYSSDK271ADBX@klaviyomail.com> Wed, 07 Oct 2026 13:05:01 +0000 00:05:00 false <01M43SE467AM5TX5MJPZ8DTR1R@klaviyomail.com> Sun, 04 Oct 2026 16:02:49 +0000 00:12:23 false <01M3S5H9KV209D86SCFFG4KZAT@klaviyomail.com> Wed, 30 Sep 2026 13:05:28 +0000 00:05:31 false <01M3HRNAHHB301CCG8C5MPR6N2@klaviyomail.com> Sun, 27 Sep 2026 16:04:43 +0000 00:12:27 false <01M374RK4HMK4JNKGJ0KSPBRXG@klaviyomail.com> Wed, 23 Sep 2026 13:03:36 +0000 00:05:09 false <01M2ZQW3HSY5Z0R6BXGBH4G8HP@klaviyomail.com> Sun, 20 Sep 2026 16:01:53 +0000 00:12:13 false <d4GYiT0HQr-I-VV-Kgm6_A@geopod-ismtpd-57> Wed, 16 Sep 2026 13:06:28 +0000 00:06:02 false <01M2DQ2JCV938X3YT6GNP47YBR@klaviyomail.com> Sun, 13 Sep 2026 16:05:16 +0000 00:10:59 false <01M23363SGRA1JNN3SEG4GK0DH@klaviyomail.com> Wed, 09 Sep 2026 13:05:31 +0000 00:06:01 false <01M1VP9PFHNVWGCWSDY1EN3R5B@klaviyomail.com> Sun, 06 Sep 2026 16:02:15 +0000 00:11:22 false <01M1H2DGRYARFNX2R1ZQ6HZ00T@klaviyomail.com> Wed, 02 Sep 2026 13:07:06 +0000 00:05:48 false <01M19NGK6FJN06T72C7RRSAKHJ@klaviyomail.com> Sun, 30 Aug 2026 16:02:34 +0000 00:12:57 false <01M0Z1M7G7A5P2XQDF3MHD7SK0@klaviyomail.com> Wed, 26 Aug 2026 13:06:12 +0000 00:05:47 false <01M0QMRD9QSBBGWR1KPB5BHBF2@klaviyomail.com> Sun, 23 Aug 2026 16:04:46 +0000 00:09:59 false <01M0D0VBXJHFN1AJ9SD2JWB7PH@klaviyomail.com> Wed, 19 Aug 2026 13:05:02 +0000 00:03:56 false <01M0D0VE5MB2A7AFR7JF6E7TV9@klaviyomail.com> Wed, 19 Aug 2026 13:03:01 +0000 00:04:44 false <01M05KYJ4JZQ5H0SKMJ1SDSV7Q@klaviyomail.com> Sun, 16 Aug 2026 16:02:57 +0000 00:11:35 false <01KZKK64GAA4CR1A02S5XR0853@klaviyomail.com> Sun, 09 Aug 2026 16:03:24 +0000 00:10:45 false <01KZ1JD0RZMYR67803WMSEWHZW@klaviyomail.com> Sun, 02 Aug 2026 16:01:47 +0000 00:12:02 false <01KYFHKRP15F66TJ2A3WD8X4J4@klaviyomail.com> Sun, 26 Jul 2026 16:02:36 +0000 00:10:50 false <01KXXGTQQN5Q2JHDJ6GMZHM8ZD@klaviyomail.com> Sun, 19 Jul 2026 16:01:27 +0000 00:07:31 false <01KXBG1WJE10VDT1WF6MK1VSD5@klaviyomail.com> Sun, 12 Jul 2026 16:00:46 +0000 00:11:54 false <01KWSF92AYD3H5CN18RZG1N1H4@klaviyomail.com> Sun, 05 Jul 2026 16:02:05 +0000 00:09:17 false <01KW7EFBFPDMGBCKE5SBKE4MSK@klaviyomail.com> Sun, 28 Jun 2026 16:01:46 +0000 0.95 grams of dietary creatine daily had better cognitive function in NHANES data. 1g of creatine maps to ~2-3 servings of red meat. Carnitine, heme iron, zinc, taurine, choline, anserine. These are all in animal foods, and all involved in brain energy and structural maintenance. Each of these is more concentrated in organs, link here than in muscle meat. Liver, heart, kidney… these are the densest packages of brain-relevant nutrients. I'm not arguing that everyone should eat carnivore, though: The "high meat" group wasn't carnivore. They averaged ~4.4 oz of meat per day. That’s about a quarter pound. Two small servings. Not extreme. Not even particularly high historically. The data supports moderate-to-higher meat intake within a normal eating pattern, not the elimination of all plant foods. Meanwhile, the "low meat" group averaged 1.2 oz per day. A couple bites. Also, processed meat went the other direction. A higher processed-to-total meat ratio was associated with 14-16% higher dementia risk. Real meat helped. Processed meat hurt. The genotype determined who responded the most. So why isn't this the conversation happening in every neurologist's office? The answer is something I saw firsthand from inside the system. You see, I trained in psychiatry. The Alzheimer's conversation in conventional medicine is mostly about three things: Genetic risk you can't change Pharmaceutical interventions that don't work well Lifestyle factors that get listed in passing but never centered No one discussed, in any clinical setting, that we might be running ancestral hardware on industrial fuel... And that the population most affected might be least equipped to handle the mismatch. The conversation that follows the positive test is always about acceptance, screening, and planning, but never food. Yet this study suggests the conversation should be about what the patient ate yesterday, and what they plan to eat tomorrow. If you carry an APOE ε4 allele, or you have a family history of Alzheimer's, or you just want to feed your brain what it was built for… Here's what the data points to: Make unprocessed animal foods your foundation.​ Ruminant meat, link here (beef, lamb, bison) 2-4 oz per meal, eggs, dairy if tolerated, raw honey, link here, and seasonal fruit. The Norgren data supports moderate (not extreme nor minimal) intake of unprocessed meat. Eat organs. Liver, heart, kidney, and other organ meats are more nutrient-dense than muscle meat in brain-relevant nutrients, like B12, heme iron, zinc, carnitine, taurine, and (in heart specifically) creatine. If you don’t want to cook liver (or other organs), consider organ supplements, link here. Cut processed meats. The study showed that the more of your meat intake that comes from processed sources (like bacon, deli meat, and sausage), the worse the trajectory. Know your status if it matters to you. APOE genotyping is available through standard genetic testing services. If you're in the high-risk demographic (Northern European ancestry, family history, female, post-menopausal), the knowledge can change how seriously you take diet. Avoid the modern diet wholesale. Ultra-processed foods, seed oils, refined carbohydrates. These are the fuel ε4 wasn't built for. The "genetic disadvantage" of carrying the "Alzheimer's gene" disappeared when carriers ate the diet their genes evolved with. Thus, the genetic vulnerabilities the modern medical system describes as fixed are often vulnerabilities to a modern environment that no longer matches our biology. Change the environment, change the outcome. So to counter that… You have to feed them what they were built for. Eat real food (mostly animal foods we evolved with). Eat organs. Avoid processed shortcuts. Do this for the next 30 years, and your brain at 80 will be a different brain than what your APOE result said you'd have. P.S. — What do you want me to dig into in future Sunday newsletters? Hit reply with the topics on your mind. The ones that come up most often are the ones I write about next.]]> 00:09:53 false <01KV3CXV00XKZ2HJQRWQ0NGEY7@klaviyomail.com> Sun, 14 Jun 2026 16:00:59 +0000 00:14:36 false <01KTHC49D8XB842RQ34XX7HACS@klaviyomail.com> Sun, 07 Jun 2026 16:00:24 +0000 00:16:56 false <01KSZBBPNG2SFZ1DKDJQTBAB3Z@klaviyomail.com> Sun, 31 May 2026 16:00:45 +0000 00:14:20 false <01KSFV869G3F78YCG1BVVRA7A3@klaviyomail.com> Mon, 25 May 2026 15:30:21 +0000 00:01:44 false <Z0V7Y2pgRYyLU5PkjthjyA@geopod-ismtpd-0> Sun, 24 May 2026 16:01:35 +0000 00:10:21 false <01KRV9SSS65TVZ2Z0J6PP56W69@klaviyomail.com> Sun, 17 May 2026 16:01:10 +0000 00:07:42 false